Antitumor activity of ( )-a-bisabolol-based thiosemicarbazones against human tumor cell lines

Detalhes bibliográficos
Autor(a) principal: Silva, Alan P. da
Data de Publicação: 2010
Outros Autores: Martini, Manuele V., Oliveira, Cecília M.A. de, Cunha, Silvio do Desterro, Carvalho, João E. de, Ruiz, Ana L. T. G., Silva, Cleuza C. da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5752
Resumo: Acesso restrito: Texto completo. p. 2987-2993.
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spelling Silva, Alan P. daMartini, Manuele V.Oliveira, Cecília M.A. deCunha, Silvio do DesterroCarvalho, João E. deRuiz, Ana L. T. G.Silva, Cleuza C. daSilva, Alan P. daMartini, Manuele V.Oliveira, Cecília M.A. deCunha, Silvio do DesterroCarvalho, João E. deRuiz, Ana L. T. G.Silva, Cleuza C. da2012-04-26T12:09:36Z20100223-5234http://www.repositorio.ufba.br/ri/handle/ri/5752v. 45, n. 7Acesso restrito: Texto completo. p. 2987-2993.A series of thiosemicarbazones deriving from the natural sesquiterpene ( )-a-bisabolol were synthesized and tested against a panel of eight human tumor cell lines to evaluate their anti-tumor potential. Some of the compounds exhibited inhibitory effects on the growth of a wide range of cancer cell lines, but myeloid leukemia cells (K-562) were especially sensitive to all tested thiosemicarbazones (GI50 0.01e4.22 mM). Among the analogues, the ketone derivative 3l was the most active, exhibiting potent antitumoral activity (GI50 0.01 mM) and high selectivity for K-562 cells (dTGI 505). It also demonstrated high cytotoxicity, with an LC50 of 1.55 mM for the K-562 cells, but it showed only moderate selectivity dLC50 38.5 mM). Through structureeactivity relationship studies, we identified some structural requirement for the antitumoral activity exhibited by these promising compounds.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-04-26T12:09:36Z No. of bitstreams: 1 __ac.els-cdn.com_S022352...632095c91c3445aec3cc9216904c2.pdf: 185232 bytes, checksum: bf14ba2f81ecd9cf7b0e4f1165ddb18d (MD5)Made available in DSpace on 2012-04-26T12:09:36Z (GMT). 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dc.title.pt_BR.fl_str_mv Antitumor activity of ( )-a-bisabolol-based thiosemicarbazones against human tumor cell lines
dc.title.alternative.pt_BR.fl_str_mv European Journal of Medicinal Chemistry
title Antitumor activity of ( )-a-bisabolol-based thiosemicarbazones against human tumor cell lines
spellingShingle Antitumor activity of ( )-a-bisabolol-based thiosemicarbazones against human tumor cell lines
Silva, Alan P. da
Thiosemicarbazones
a-Bisabolol
Antitumoral activity
title_short Antitumor activity of ( )-a-bisabolol-based thiosemicarbazones against human tumor cell lines
title_full Antitumor activity of ( )-a-bisabolol-based thiosemicarbazones against human tumor cell lines
title_fullStr Antitumor activity of ( )-a-bisabolol-based thiosemicarbazones against human tumor cell lines
title_full_unstemmed Antitumor activity of ( )-a-bisabolol-based thiosemicarbazones against human tumor cell lines
title_sort Antitumor activity of ( )-a-bisabolol-based thiosemicarbazones against human tumor cell lines
author Silva, Alan P. da
author_facet Silva, Alan P. da
Martini, Manuele V.
Oliveira, Cecília M.A. de
Cunha, Silvio do Desterro
Carvalho, João E. de
Ruiz, Ana L. T. G.
Silva, Cleuza C. da
author_role author
author2 Martini, Manuele V.
Oliveira, Cecília M.A. de
Cunha, Silvio do Desterro
Carvalho, João E. de
Ruiz, Ana L. T. G.
Silva, Cleuza C. da
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Alan P. da
Martini, Manuele V.
Oliveira, Cecília M.A. de
Cunha, Silvio do Desterro
Carvalho, João E. de
Ruiz, Ana L. T. G.
Silva, Cleuza C. da
Silva, Alan P. da
Martini, Manuele V.
Oliveira, Cecília M.A. de
Cunha, Silvio do Desterro
Carvalho, João E. de
Ruiz, Ana L. T. G.
Silva, Cleuza C. da
dc.subject.por.fl_str_mv Thiosemicarbazones
a-Bisabolol
Antitumoral activity
topic Thiosemicarbazones
a-Bisabolol
Antitumoral activity
description Acesso restrito: Texto completo. p. 2987-2993.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-04-26T12:09:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5752
dc.identifier.issn.none.fl_str_mv 0223-5234
dc.identifier.number.pt_BR.fl_str_mv v. 45, n. 7
identifier_str_mv 0223-5234
v. 45, n. 7
url http://www.repositorio.ufba.br/ri/handle/ri/5752
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv DOI: 10.1016/j.ejmech.2010.03.026
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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