FOXP3 expression in papillary thyroid carcinoma with and without Hashimoto's thyroiditis

Detalhes bibliográficos
Autor(a) principal: Neves Júnior, Murilo Pedreira
Data de Publicação: 2013
Outros Autores: Carvalho Filho, Edgar Marcelino de, Camandaroba, Marcos Pedro Guedes, Mascarenhas, Milena Brachmans, Correia, Thaizza Cavalcante, Neves, Yuri Costa Sarno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16385
Resumo: p. 283-287
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spelling Neves Júnior, Murilo PedreiraCarvalho Filho, Edgar Marcelino deCamandaroba, Marcos Pedro GuedesMascarenhas, Milena BrachmansCorreia, Thaizza CavalcanteNeves, Yuri Costa SarnoNeves Júnior, Murilo PedreiraCarvalho Filho, Edgar Marcelino deCamandaroba, Marcos Pedro GuedesMascarenhas, Milena BrachmansCorreia, Thaizza CavalcanteNeves, Yuri Costa Sarno2014-10-10T15:10:14Z2014-10-10T15:10:14Z20131676-2444http://repositorio.ufba.br/ri/handle/ri/16385v. 49, n. 4p. 283-287INTRODUCTION: The forkhead box P3 (FOXP3) plays a role in cell development and control. In the presence of abnormal FOXP3 expression, tumor cells may evade the immunosurveillance of lymphoid cells, the first step for the maintenance of cancer cells in the thyroid tissue. OBJECTIVE: To identify the presence of FOXP3 in papillary thyroid carcinoma (PTC) with and without Hashimoto's Thyroiditis (HT). METHODS: We conducted a series study of cases collected from 2000 to 2008, when 1,438 thyroidectomies were performed. We selected those diagnosed with PTC, comprising 466 cases. 30 patients were randomly selected for purposes of immunohistochemistry with antibodies against FOXP3. RESULT: FOXP3 revealed high positivity for PTC and positive immunostaining was present in 21 (72.4%) from all analyzed cases. There was no difference regarding coexistent HT or not. DISCUSSION AND CONCLUSION: In the present study, it was evidenced that the focal or diffuse FOXP3 expression was commonly observed in neoplastic cells from PTC, hence indicating that the assessment of this molecule expression in suspected cases of thyroid cancer may contribute to its diagnosis.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-05-13T14:11:41Z No. of bitstreams: 1 10.1590S1676-24442013000400010.pdf: 288401 bytes, checksum: 45ebdff9413479330d11d67675bbbdbe (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-10-10T15:10:14Z (GMT) No. of bitstreams: 1 10.1590S1676-24442013000400010.pdf: 288401 bytes, checksum: 45ebdff9413479330d11d67675bbbdbe (MD5)Made available in DSpace on 2014-10-10T15:10:14Z (GMT). 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dc.title.pt_BR.fl_str_mv FOXP3 expression in papillary thyroid carcinoma with and without Hashimoto's thyroiditis
dc.title.alternative.pt_BR.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial
title FOXP3 expression in papillary thyroid carcinoma with and without Hashimoto's thyroiditis
spellingShingle FOXP3 expression in papillary thyroid carcinoma with and without Hashimoto's thyroiditis
Neves Júnior, Murilo Pedreira
Thyroiditis
Papillary thyroid carcinoma
FOXP3
Immunohistochemistry
Pathology
Hashimoto's thyroiditis
title_short FOXP3 expression in papillary thyroid carcinoma with and without Hashimoto's thyroiditis
title_full FOXP3 expression in papillary thyroid carcinoma with and without Hashimoto's thyroiditis
title_fullStr FOXP3 expression in papillary thyroid carcinoma with and without Hashimoto's thyroiditis
title_full_unstemmed FOXP3 expression in papillary thyroid carcinoma with and without Hashimoto's thyroiditis
title_sort FOXP3 expression in papillary thyroid carcinoma with and without Hashimoto's thyroiditis
author Neves Júnior, Murilo Pedreira
author_facet Neves Júnior, Murilo Pedreira
Carvalho Filho, Edgar Marcelino de
Camandaroba, Marcos Pedro Guedes
Mascarenhas, Milena Brachmans
Correia, Thaizza Cavalcante
Neves, Yuri Costa Sarno
author_role author
author2 Carvalho Filho, Edgar Marcelino de
Camandaroba, Marcos Pedro Guedes
Mascarenhas, Milena Brachmans
Correia, Thaizza Cavalcante
Neves, Yuri Costa Sarno
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Neves Júnior, Murilo Pedreira
Carvalho Filho, Edgar Marcelino de
Camandaroba, Marcos Pedro Guedes
Mascarenhas, Milena Brachmans
Correia, Thaizza Cavalcante
Neves, Yuri Costa Sarno
Neves Júnior, Murilo Pedreira
Carvalho Filho, Edgar Marcelino de
Camandaroba, Marcos Pedro Guedes
Mascarenhas, Milena Brachmans
Correia, Thaizza Cavalcante
Neves, Yuri Costa Sarno
dc.subject.por.fl_str_mv Thyroiditis
Papillary thyroid carcinoma
FOXP3
Immunohistochemistry
Pathology
Hashimoto's thyroiditis
topic Thyroiditis
Papillary thyroid carcinoma
FOXP3
Immunohistochemistry
Pathology
Hashimoto's thyroiditis
description p. 283-287
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-10-10T15:10:14Z
dc.date.available.fl_str_mv 2014-10-10T15:10:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16385
dc.identifier.issn.none.fl_str_mv 1676-2444
dc.identifier.number.pt_BR.fl_str_mv v. 49, n. 4
identifier_str_mv 1676-2444
v. 49, n. 4
url http://repositorio.ufba.br/ri/handle/ri/16385
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S1676-24442013000400010
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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