T Cell Response of Asymptomatic Leishmania chagasi Infected Subjects to Recombinant Leishmania Antigens

Detalhes bibliográficos
Autor(a) principal: Costa, Sérgio Ricardo
Data de Publicação: 1999
Outros Autores: D'Oliveira Junior, Argemiro, Bacellar, Maria Olívia Amado Ramos, Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12794
Resumo: p. 367-370
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spelling Costa, Sérgio RicardoD'Oliveira Junior, ArgemiroBacellar, Maria Olívia Amado RamosCarvalho Filho, Edgar Marcelino deCosta, Sérgio RicardoD'Oliveira Junior, ArgemiroBacellar, Maria Olívia Amado RamosCarvalho Filho, Edgar Marcelino de2013-09-02T15:33:59Z2013-09-02T15:33:59Z19990074-0276http://www.repositorio.ufba.br/ri/handle/ri/12794v. 94, n. 3p. 367-370In areas of Leishmania chagasi transmission the ability to control leishmania infection is associated with IFN-g production. In visceral leishmaniasis down-regulation of T cell responses is mediated by interleukin-10 (IL-10). In this study we evaluated the lymphoproliferative response, IFN-g and IL-10 production on lymphocyte cultures stimulated with recombinant leishmania antigens in subjects with asymptomatic L. chagasi infection. There was a statistically significant difference in the lymphoproliferative response of the subjects with asymptomatic infection as compared to patients with visceral leishmaniasis and healthy subjects with respect to crude antigens (p<0.01), gp-63 (p<0.05) and hsp-70 (p<0.01), as well as between asymptomatic L. chagasi infected subjects and patients with visceral leishmaniasis with respect to the response to all antigens tested. The IFN-g production observed in the group with asymptomatic infection with all the three recombinant antigens tested was higher (p<0.01) than that observed in patients with visceral leishmaniasis and in healthy subjects. Furthermore, in individuals with asymptomatic infection, IL-10 levels in cultures stimulated with recombinant antigens were very low. This study shows that lymphocytes from individuals with asymptomatic L. chagasi infection are able to recognize recombinant leishmania antigens with production of a cytokine that is associated with leishmania killing.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-08-07T19:53:03Z No. of bitstreams: 1 5555555555555555555555.pdf: 97540 bytes, checksum: ab199e6af734608c8d5bfb3b3e4bfe0f (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-09-02T15:33:59Z (GMT) No. of bitstreams: 1 5555555555555555555555.pdf: 97540 bytes, checksum: ab199e6af734608c8d5bfb3b3e4bfe0f (MD5)Made available in DSpace on 2013-09-02T15:33:59Z (GMT). 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dc.title.pt_BR.fl_str_mv T Cell Response of Asymptomatic Leishmania chagasi Infected Subjects to Recombinant Leishmania Antigens
dc.title.alternative.pt_BR.fl_str_mv Memórias do Instituto Oswaldo Cruz
title T Cell Response of Asymptomatic Leishmania chagasi Infected Subjects to Recombinant Leishmania Antigens
spellingShingle T Cell Response of Asymptomatic Leishmania chagasi Infected Subjects to Recombinant Leishmania Antigens
Costa, Sérgio Ricardo
Asymptomatic Leishmania chagasi infection
Recombinant leishmania antigens
T cell responses
title_short T Cell Response of Asymptomatic Leishmania chagasi Infected Subjects to Recombinant Leishmania Antigens
title_full T Cell Response of Asymptomatic Leishmania chagasi Infected Subjects to Recombinant Leishmania Antigens
title_fullStr T Cell Response of Asymptomatic Leishmania chagasi Infected Subjects to Recombinant Leishmania Antigens
title_full_unstemmed T Cell Response of Asymptomatic Leishmania chagasi Infected Subjects to Recombinant Leishmania Antigens
title_sort T Cell Response of Asymptomatic Leishmania chagasi Infected Subjects to Recombinant Leishmania Antigens
author Costa, Sérgio Ricardo
author_facet Costa, Sérgio Ricardo
D'Oliveira Junior, Argemiro
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino de
author_role author
author2 D'Oliveira Junior, Argemiro
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
dc.contributor.author.fl_str_mv Costa, Sérgio Ricardo
D'Oliveira Junior, Argemiro
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino de
Costa, Sérgio Ricardo
D'Oliveira Junior, Argemiro
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv Asymptomatic Leishmania chagasi infection
Recombinant leishmania antigens
T cell responses
topic Asymptomatic Leishmania chagasi infection
Recombinant leishmania antigens
T cell responses
description p. 367-370
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2013-09-02T15:33:59Z
dc.date.available.fl_str_mv 2013-09-02T15:33:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12794
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.number.pt_BR.fl_str_mv v. 94, n. 3
identifier_str_mv 0074-0276
v. 94, n. 3
url http://www.repositorio.ufba.br/ri/handle/ri/12794
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Memórias do Instituto Oswaldo Cruz
publisher.none.fl_str_mv Memórias do Instituto Oswaldo Cruz
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0074-02761999000300015
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
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institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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