Flavonoids inhibit angiogenic cytokine production by human glioma cells
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14769 |
Resumo: | Texto completo: acesso restrito. p. 916–921 |
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Freitas, SandraCosta, Silvia LimaAzevedo, CamilaCarvalho, GersonFreire, SongeliBarbosa, Pedro RochaVelozo, Eudes da SilvaSchaer, Robert EduardTardy, Marcienne BlochNascimento, Roberto José MeyerNascimento, Ivana Lúcia de OliveiraFreitas, SandraCosta, Silvia LimaAzevedo, CamilaCarvalho, GersonFreire, SongeliBarbosa, Pedro RochaVelozo, Eudes da SilvaSchaer, Robert EduardTardy, Marcienne BlochNascimento, Roberto José MeyerNascimento, Ivana Lúcia de Oliveira2014-03-21T20:41:51Z20110951-418X,http://repositorio.ufba.br/ri/handle/ri/14769v. 25, n. 6Texto completo: acesso restrito. p. 916–921VEGF and TGF-β1 are cytokines that stimulate tissue invasion and angiogenesis. These factors are considered as molecular targets for the therapy of glioblastoma. Bevacizumab, a recombinant humanized monoclonal antibody developed against VEGF, inhibits endothelial cell proliferation and vessel formation. Flavonoids obtained from Dimorphandra mollis and Croton betulaster have been described as proliferation inhibitors of a human glioblastoma derived cell line. VEGF and TGF-β1 levels were dosed by ELISA in a GL-15 cell line treated with bevacizumab and also with the flavonoids rutin, 5-hydroxy-7,4′-dimethoxyflavone, casticin, apigenin and penduletin. Rutin reduced the VEGF and TGF-β1 levels after 24 h but not after 72 h. The other flavonoids significantly reduced TGF-β1 production. Bevacizumab reduced only the VEGF levels in the supernatant from GL-15 cultures. These results suggest that the flavonoids studied, and commonly used in popular medicine, present an interesting subject of study due to their potential effect as angiogenic factor inhibitors.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-03-20T13:51:10Z No. of bitstreams: 1 Sandra Freitas.pdf: 611530 bytes, checksum: bb4cd76b6dda0446499156935df54114 (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-03-21T20:41:50Z (GMT) No. of bitstreams: 1 Sandra Freitas.pdf: 611530 bytes, checksum: bb4cd76b6dda0446499156935df54114 (MD5)Made available in DSpace on 2014-03-21T20:41:51Z (GMT). No. of bitstreams: 1 Sandra Freitas.pdf: 611530 bytes, checksum: bb4cd76b6dda0446499156935df54114 (MD5) Previous issue date: 2011http://dx.doi.org/ 10.1002/ptr.3338reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAngiogenesisAngiogenic factor inhibitorsFlavonoidsVEGFTGF-β1GlioblastomaFlavonoids inhibit angiogenic cytokine production by human glioma cellsPhytotherapy Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14769/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINALSandra Freitas.pdfSandra Freitas.pdfapplication/pdf611530https://repositorio.ufba.br/bitstream/ri/14769/1/Sandra%20Freitas.pdfbb4cd76b6dda0446499156935df54114MD51TEXTSandra Freitas.pdf.txtSandra Freitas.pdf.txtExtracted texttext/plain24005https://repositorio.ufba.br/bitstream/ri/14769/3/Sandra%20Freitas.pdf.txt6924128bd5596541cec1119aa5fd68fcMD53ri/147692022-07-05 14:03:28.281oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:28Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Flavonoids inhibit angiogenic cytokine production by human glioma cells |
| dc.title.alternative.pt_BR.fl_str_mv |
Phytotherapy Research |
| title |
Flavonoids inhibit angiogenic cytokine production by human glioma cells |
| spellingShingle |
Flavonoids inhibit angiogenic cytokine production by human glioma cells Freitas, Sandra Angiogenesis Angiogenic factor inhibitors Flavonoids VEGF TGF-β1 Glioblastoma |
| title_short |
Flavonoids inhibit angiogenic cytokine production by human glioma cells |
| title_full |
Flavonoids inhibit angiogenic cytokine production by human glioma cells |
| title_fullStr |
Flavonoids inhibit angiogenic cytokine production by human glioma cells |
| title_full_unstemmed |
Flavonoids inhibit angiogenic cytokine production by human glioma cells |
| title_sort |
Flavonoids inhibit angiogenic cytokine production by human glioma cells |
| author |
Freitas, Sandra |
| author_facet |
Freitas, Sandra Costa, Silvia Lima Azevedo, Camila Carvalho, Gerson Freire, Songeli Barbosa, Pedro Rocha Velozo, Eudes da Silva Schaer, Robert Eduard Tardy, Marcienne Bloch Nascimento, Roberto José Meyer Nascimento, Ivana Lúcia de Oliveira |
| author_role |
author |
| author2 |
Costa, Silvia Lima Azevedo, Camila Carvalho, Gerson Freire, Songeli Barbosa, Pedro Rocha Velozo, Eudes da Silva Schaer, Robert Eduard Tardy, Marcienne Bloch Nascimento, Roberto José Meyer Nascimento, Ivana Lúcia de Oliveira |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Freitas, Sandra Costa, Silvia Lima Azevedo, Camila Carvalho, Gerson Freire, Songeli Barbosa, Pedro Rocha Velozo, Eudes da Silva Schaer, Robert Eduard Tardy, Marcienne Bloch Nascimento, Roberto José Meyer Nascimento, Ivana Lúcia de Oliveira Freitas, Sandra Costa, Silvia Lima Azevedo, Camila Carvalho, Gerson Freire, Songeli Barbosa, Pedro Rocha Velozo, Eudes da Silva Schaer, Robert Eduard Tardy, Marcienne Bloch Nascimento, Roberto José Meyer Nascimento, Ivana Lúcia de Oliveira |
| dc.subject.por.fl_str_mv |
Angiogenesis Angiogenic factor inhibitors Flavonoids VEGF TGF-β1 Glioblastoma |
| topic |
Angiogenesis Angiogenic factor inhibitors Flavonoids VEGF TGF-β1 Glioblastoma |
| description |
Texto completo: acesso restrito. p. 916–921 |
| publishDate |
2011 |
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2011 |
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2014-03-21T20:41:51Z |
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info:eu-repo/semantics/publishedVersion |
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0951-418X, |
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v. 25, n. 6 |
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0951-418X, v. 25, n. 6 |
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