Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection

Detalhes bibliográficos
Autor(a) principal: Santos, Silvane Maria Braga
Data de Publicação: 2004
Outros Autores: Porto, Maria Aurélia da Fonseca, Muniz, André Luís Nunes, Jesus, Amélia Ribeiro de, Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8345
Resumo: p. 121-126
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spelling Santos, Silvane Maria BragaPorto, Maria Aurélia da FonsecaMuniz, André Luís NunesJesus, Amélia Ribeiro deCarvalho Filho, Edgar Marcelino deSantos, Silvane Maria BragaPorto, Maria Aurélia da FonsecaMuniz, André Luís NunesJesus, Amélia Ribeiro deCarvalho Filho, Edgar Marcelino de2013-02-04T15:45:03Z2013-02-04T15:45:03Z20040074-0276http://www.repositorio.ufba.br/ri/handle/ri/8345v. 99, n. 1p. 121-126Human T cell leukemia virus type-I (HTLV-I) infection is associated with spontaneous T cell activation and uncontrolled lymphocyte proliferation. An exacerbated type-1 immune response with production of pro-inflammatory cytokines (interferon-g and tumor necrosis factor-a) is significantly higher in patients with myelopathy associated to HTLV-I than in HTLV-I asymptomatic carriers. In contrast with HTLV-I, a chronic Schistosoma mansoni infection is associated with a type-2 immune response with high levels of interleukin (IL-4, IL-5, and IL-10) and low levels of IFN-g. In this study, clinical and immunological consequences of the HTLV-I and S. mansoni infection were evaluated. The immune response in patients with schistosomiasis co-infected with HTLV-I showed low levels of IL-5 (p < 0.05) in peripheral blood mononuclear cells cultures stimulated with S. mansoni antigen (SWAP) and decreased SWAP-specific IgE levels when compared with patients with only schistosomiasis (p < 0.05). Liver fibrosis was mild in all HTLV-I co-infected patients. Immunological response was also compared in individuals who had only HTLV-I infection with those who were co-infected with HTLV-I and helminths (S. mansoni and Strongyloides stercoralis). In patients HTLV-I positive co-infected with helminths the IFN-g levels were lower than in individuals who had only HTLV-I. Moreover, there were fewer cells expressing IFN-g and more cells expressing IL-10 in individuals co-infected with HTLV-I and helminths. These dates indicate that HTLV-I infection decrease type 2-response and IgE synthesis and are inversely associated with the development of liver fibrosis. Moreover, helminths may protect HTLV-I infected patients to produce large quantities of pro-inflammatory cytokines such as IFN-g.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2013-01-31T19:32:22Z No. of bitstreams: 1 v99s1a22.pdf: 64731 bytes, checksum: e1fc94bb8db4953dad15dd6e54ce1bf9 (MD5)Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-02-04T15:45:03Z (GMT) No. of bitstreams: 1 v99s1a22.pdf: 64731 bytes, checksum: e1fc94bb8db4953dad15dd6e54ce1bf9 (MD5)Made available in DSpace on 2013-02-04T15:45:03Z (GMT). No. of bitstreams: 1 v99s1a22.pdf: 64731 bytes, checksum: e1fc94bb8db4953dad15dd6e54ce1bf9 (MD5) Previous issue date: 2004Rio de Janeirohttp://dx.doi.org/10.1590/S0074-02762004000900022reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAhuman T cell leukemia virus type-1Schistoma mansonico-infectionClinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infectionMemórias do Instituto Oswaldo Cruzinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALv99s1a22.pdfv99s1a22.pdfapplication/pdf64731https://repositorio.ufba.br/bitstream/ri/8345/1/v99s1a22.pdfe1fc94bb8db4953dad15dd6e54ce1bf9MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8345/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTv99s1a22.pdf.txtv99s1a22.pdf.txtExtracted texttext/plain32681https://repositorio.ufba.br/bitstream/ri/8345/3/v99s1a22.pdf.txtd6c318ecf4290fbb52e91ec1fd18136cMD53ri/83452022-07-05 14:03:03.068oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection
dc.title.alternative.pt_BR.fl_str_mv Memórias do Instituto Oswaldo Cruz
title Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection
spellingShingle Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection
Santos, Silvane Maria Braga
human T cell leukemia virus type-1
Schistoma mansoni
co-infection
title_short Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection
title_full Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection
title_fullStr Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection
title_full_unstemmed Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection
title_sort Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection
author Santos, Silvane Maria Braga
author_facet Santos, Silvane Maria Braga
Porto, Maria Aurélia da Fonseca
Muniz, André Luís Nunes
Jesus, Amélia Ribeiro de
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Porto, Maria Aurélia da Fonseca
Muniz, André Luís Nunes
Jesus, Amélia Ribeiro de
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos, Silvane Maria Braga
Porto, Maria Aurélia da Fonseca
Muniz, André Luís Nunes
Jesus, Amélia Ribeiro de
Carvalho Filho, Edgar Marcelino de
Santos, Silvane Maria Braga
Porto, Maria Aurélia da Fonseca
Muniz, André Luís Nunes
Jesus, Amélia Ribeiro de
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv human T cell leukemia virus type-1
Schistoma mansoni
co-infection
topic human T cell leukemia virus type-1
Schistoma mansoni
co-infection
description p. 121-126
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2013-02-04T15:45:03Z
dc.date.available.fl_str_mv 2013-02-04T15:45:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8345
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.number.pt_BR.fl_str_mv v. 99, n. 1
identifier_str_mv 0074-0276
v. 99, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/8345
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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