Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy

Detalhes bibliográficos
Autor(a) principal: Silveira, Laura
Data de Publicação: 2013
Outros Autores: Torres, Isabelle de Sousa Medeiros, Salvino, Marco A., Follador, Ivonise, Bittencourt, Achilea Candida Lisboa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16396
Resumo: Texto completo: acesso restrito. p. 67-71
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spelling Silveira, LauraTorres, Isabelle de Sousa MedeirosSalvino, Marco A.Follador, IvoniseBittencourt, Achilea Candida LisboaSilveira, LauraTorres, Isabelle de Sousa MedeirosSalvino, Marco A.Follador, IvoniseBittencourt, Achilea Candida Lisboa2014-10-10T15:15:29Z20130193-1091http://repositorio.ufba.br/ri/handle/ri/16396v. 35, n. 4Texto completo: acesso restrito. p. 67-71Acquired cutis laxa (ACL) is a rare connective tissue disorder that affects the skin elastic fibers, resulting in the loss of elasticity. In 50% of cases, this condition is associated with other diseases, particularly plasma-cell dyscrasias. This report describes a case of ACL with unusual clinical and histopathological characteristics. A 29-year-old man presented with diffuse erythematous plaques that had first appeared 5 months previously. Examination revealed multiple flaccid erythematous plaques on his trunk, neck, and skinfolds. Immunophenotyping of bone marrow aspirate revealed 7% of monoclonal plasma cells with lambda light chain expression. Skin biopsy histology revealed foci of interstitial granulomatous reaction. Weigert stain showed a loss of elastic fibers in the dermis, areas with thickened fibers and elastophagocytosis. Immunohistochemistry was positive for CD68. The cutaneous findings enabled an early diagnosis of IgG lambda monoclonal gammopathy to be made. Microscopic examination revealed an interstitial granulomatous reaction and severe alterations in the elastic fibers that varied in intensity in the different biopsies. Curiously, little has been mentioned in the literature regarding the presence of an interstitial granulomatous reaction in ACL. It is our belief that this reaction is secondary to the degenerative process of the elastic fibers.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-06-05T13:41:36Z No. of bitstreams: 1 00000372-201306000-00032.pdf: 792876 bytes, checksum: 0906093cb7ec417cb1668aa57f5ba1fe (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-10-10T15:15:29Z (GMT) No. of bitstreams: 1 00000372-201306000-00032.pdf: 792876 bytes, checksum: 0906093cb7ec417cb1668aa57f5ba1fe (MD5)Made available in DSpace on 2014-10-10T15:15:29Z (GMT). No. of bitstreams: 1 00000372-201306000-00032.pdf: 792876 bytes, checksum: 0906093cb7ec417cb1668aa57f5ba1fe (MD5) Previous issue date: 2013http://dx.doi.org/10.1097/DAD.0b013e31827bceafreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAcquired cutis laxaIgG lambda monoclonal gammopathyInterstitial granulomatous diseaseAcquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathyAmerican Journal of Dermatopathologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL00000372-201306000-00032.pdf00000372-201306000-00032.pdfapplication/pdf792876https://repositorio.ufba.br/bitstream/ri/16396/1/00000372-201306000-00032.pdf0906093cb7ec417cb1668aa57f5ba1feMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16396/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT00000372-201306000-00032.pdf.txt00000372-201306000-00032.pdf.txtExtracted texttext/plain18104https://repositorio.ufba.br/bitstream/ri/16396/3/00000372-201306000-00032.pdf.txtf606ae072f39f79d6e145126468e1a3eMD53ri/163962022-07-05 14:03:03.053oai:repositorio.ufba.br:ri/16396VGVybW8gZGUgTGljZW4/YSwgbj9vIGV4Y2x1c2l2bywgcGFyYSBvIGRlcD9zaXRvIG5vIFJlcG9zaXQ/cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZCQS4KCiBQZWxvIHByb2Nlc3NvIGRlIHN1Ym1pc3M/byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldSByZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIAplc3NlIHRlcm1vIGRlIGxpY2VuP2EsIGNvbmNlZGUgYW8gUmVwb3NpdD9yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSAKbyBkaXJlaXRvIGRlIG1hbnRlciB1bWEgYz9waWEgZW0gc2V1IHJlcG9zaXQ/cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCBkZSBwcmVzZXJ2YT8/by4gCkVzc2VzIHRlcm1vcywgbj9vIGV4Y2x1c2l2b3MsIG1hbnQ/bSBvcyBkaXJlaXRvcyBkZSBhdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIApjb21vIHBhcnRlIGRvIGFjZXJ2byBpbnRlbGVjdHVhbCBkZXNzYSBVbml2ZXJzaWRhZGUuCgogUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVpPz9vLCBlc3NlIHRlcm1vIGRlIGxpY2VuP2EgCmVudGVuZGUgcXVlOgoKIE1hbnRlbmRvIG9zIGRpcmVpdG9zIGF1dG9yYWlzLCByZXBhc3NhZG9zIGEgdGVyY2Vpcm9zLCBlbSBjYXNvIGRlIHB1YmxpY2E/P2VzLCBvIHJlcG9zaXQ/cmlvCnBvZGUgcmVzdHJpbmdpciBvIGFjZXNzbyBhbyB0ZXh0byBpbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1hPz9lcyBzb2JyZSBvIGRvY3VtZW50bwooTWV0YWRhZG9zIGVzY3JpdGl2b3MpLgoKIERlc3RhIGZvcm1hLCBhdGVuZGVuZG8gYW9zIGFuc2Vpb3MgZGVzc2EgdW5pdmVyc2lkYWRlIGVtIG1hbnRlciBzdWEgcHJvZHU/P28gY2llbnQ/ZmljYSBjb20gCmFzIHJlc3RyaT8/ZXMgaW1wb3N0YXMgcGVsb3MgZWRpdG9yZXMgZGUgcGVyaT9kaWNvcy4KCiBQYXJhIGFzIHB1YmxpY2E/P2VzIHNlbSBpbmljaWF0aXZhcyBxdWUgc2VndWVtIGEgcG9sP3RpY2EgZGUgQWNlc3NvIEFiZXJ0bywgb3MgZGVwP3NpdG9zIApjb21wdWxzP3Jpb3MgbmVzc2UgcmVwb3NpdD9yaW8gbWFudD9tIG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudD9tIGFjZXNzbyBpcnJlc3RyaXRvIAphbyBtZXRhZGFkb3MgZSB0ZXh0byBjb21wbGV0by4gQXNzaW0sIGEgYWNlaXRhPz9vIGRlc3NlIHRlcm1vIG4/byBuZWNlc3NpdGEgZGUgY29uc2VudGltZW50bwogcG9yIHBhcnRlIGRlIGF1dG9yZXMvZGV0ZW50b3JlcyBkb3MgZGlyZWl0b3MsIHBvciBlc3RhcmVtIGVtIGluaWNpYXRpdmFzIGRlIGFjZXNzbyBhYmVydG8uCg==Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy
dc.title.alternative.pt_BR.fl_str_mv American Journal of Dermatopathology
title Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy
spellingShingle Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy
Silveira, Laura
Acquired cutis laxa
IgG lambda monoclonal gammopathy
Interstitial granulomatous disease
title_short Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy
title_full Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy
title_fullStr Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy
title_full_unstemmed Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy
title_sort Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy
author Silveira, Laura
author_facet Silveira, Laura
Torres, Isabelle de Sousa Medeiros
Salvino, Marco A.
Follador, Ivonise
Bittencourt, Achilea Candida Lisboa
author_role author
author2 Torres, Isabelle de Sousa Medeiros
Salvino, Marco A.
Follador, Ivonise
Bittencourt, Achilea Candida Lisboa
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silveira, Laura
Torres, Isabelle de Sousa Medeiros
Salvino, Marco A.
Follador, Ivonise
Bittencourt, Achilea Candida Lisboa
Silveira, Laura
Torres, Isabelle de Sousa Medeiros
Salvino, Marco A.
Follador, Ivonise
Bittencourt, Achilea Candida Lisboa
dc.subject.por.fl_str_mv Acquired cutis laxa
IgG lambda monoclonal gammopathy
Interstitial granulomatous disease
topic Acquired cutis laxa
IgG lambda monoclonal gammopathy
Interstitial granulomatous disease
description Texto completo: acesso restrito. p. 67-71
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-10-10T15:15:29Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16396
dc.identifier.issn.none.fl_str_mv 0193-1091
dc.identifier.number.pt_BR.fl_str_mv v. 35, n. 4
identifier_str_mv 0193-1091
v. 35, n. 4
url http://repositorio.ufba.br/ri/handle/ri/16396
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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