HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis

Detalhes bibliográficos
Autor(a) principal: Lyra, André Castro
Data de Publicação: 2005
Outros Autores: Pinho, João Renato Rebello, Silva, L.K., Sousa, L., Saraceni, C. P., Braga, Eduardo Lorens, Pereira, J. E., Zarife, Maria Alice Sant'anna, Lyra, Luiz Guilherme Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6508
Resumo: p. 767-775
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spelling Lyra, André CastroPinho, João Renato RebelloSilva, L.K.Sousa, L.Saraceni, C. P.Braga, Eduardo LorensPereira, J. E.Zarife, Maria Alice Sant'annaLyra, Luiz Guilherme CostaLyra, André CastroPinho, João Renato RebelloSilva, L.K.Sousa, L.Saraceni, C. P.Braga, Eduardo LorensPereira, J. E.Zarife, Maria Alice Sant'annaLyra, Luiz Guilherme Costa2012-07-30T19:51:39Z2012-07-30T19:51:39Z20050100-879Xhttp://www.repositorio.ufba.br/ri/handle/ri/6508v. 38, n. 5p. 767-775he aim of the present study was to evaluate the prevalence of HEV, TTV and GBV-C/GBV-C/HGV in patients with acute viral hepatitis A, B and non-A-C. We evaluated sera of 94 patients from a sentinel program who had acute hepatitis A (N = 40), B (N = 42) and non-A-C (N = 12); 71 blood donors served as controls. IgM and anti-HEV IgG antibodies were detected by enzyme immunoassay using commercial kits. TTV and GBV-C/HGV were detected by nested PCR; genotyping was done by sequencing and phylogenetic analysis. Anti-HEV IgG was present in 38, 10 and 17% of patients with hepatitis A, B and non-A-C. Four patients with hepatitis A and 1 with non-A-C hepatitis also had anti-HEV IgM detected in serum. TTV was detected in 21% of patients with acute hepatitis and in 31% of donors. GBV-C/HGV was detected in 9% of patients with hepatitis, and in 10% of donors. We found TTV isolates of genotypes 1, 2, 3, and 4 and GBV-C/HGV isolates of genotypes 1 and 2. Mean aminotransferase levels were lower in patients who were TTV or GBV-C/HGV positive. In conclusion, the detection of anti-HEV IgM in some acute hepatitis A cases suggests co-infection with HEV and hepatitis E could be the etiology of a few cases of sporadic non-A-C hepatitis in Salvador, Brazil. TTV genotype 1, 2, 3 and 4 isolates and GBV-C/HGV genotype 1 and 2 strains are frequent in the studied population. TTV and GBV-C/HGV infection does not appear to have a role in the etiology of acute hepatitis.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-07-30T19:51:38Z No. of bitstreams: 1 (142).pdf: 614218 bytes, checksum: 34e3870ccd877d923bcd68fc0ace4efc (MD5)Made available in DSpace on 2012-07-30T19:51:39Z (GMT). No. of bitstreams: 1 (142).pdf: 614218 bytes, checksum: 34e3870ccd877d923bcd68fc0ace4efc (MD5) Previous issue date: 2005-05Scielohttp://dx.doi.org/10.1590/S0100-879X2005000500015reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAcute hepatitisHepatitis ETTVGBV-C/HGVGenotypeBrazilHEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitisBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6508/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL(142).pdf(142).pdfapplication/pdf614218https://repositorio.ufba.br/bitstream/ri/6508/1/%28142%29.pdf34e3870ccd877d923bcd68fc0ace4efcMD51TEXT(142).pdf.txt(142).pdf.txtExtracted texttext/plain34629https://repositorio.ufba.br/bitstream/ri/6508/3/%28142%29.pdf.txtd92265314997f45fe393610256689425MD53ri/65082022-10-17 22:37:13.163oai:repositorio.ufba.br:ri/6508VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIHJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBCgogICAgUGVsbyBwcm9jZXNzbyBkZSBzdWJtaXNz77+9byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldQpyZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBjb25jZWRlIGFvClJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSBvIGRpcmVpdG8KZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCAKZGUgcHJlc2VydmHvv73vv71vLiBFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIAphdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIGNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4gCgogICAgUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVp77+977+9bywgZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEgZW50ZW5kZSBxdWU6IAoKICAgIE1hbnRlbmRvIG9zICBkaXJlaXRvcyBhdXRvcmFpcywgcmVwYXNzYWRvcyBhIHRlcmNlaXJvcywgZW0gY2FzbyAKZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8gcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIAppbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1h77+977+9ZXMgc29icmUgbyBkb2N1bWVudG8gKE1ldGFkYWRvcyBkZXNjcml0aXZvcykuCgogRGVzdGEgZm9ybWEsIGF0ZW5kZW5kbyBhb3MgYW5zZWlvcyBkZXNzYSB1bml2ZXJzaWRhZGUgCmVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gYXMgcmVzdHJp77+977+9ZXMgaW1wb3N0YXMgcGVsb3MgCmVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4gCgogICAgUGFyYSBhcyBwdWJsaWNh77+977+9ZXMgZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgCkFjZXNzbyBBYmVydG8sIG9zIGRlcO+/vXNpdG9zIGNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gCm9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudO+/vW0gbyBhY2Vzc28gaXJyZXN0cml0byBhbyBtZXRhZGFkb3MgCmUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIApjb25zZW50aW1lbnRvIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgCmVzdGFyZW0gZW0gaW5pY2lhdGl2YXMgZGUgYWNlc3NvIGFiZXJ0by4KCiAgICBFbSBhbWJvcyBvIGNhc28sIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBwb2RlIHNlciBhY2VpdG8gcGVsbyAKYXV0b3IsIGRldGVudG9yZXMgZGUgZGlyZWl0b3MgZS9vdSB0ZXJjZWlyb3MgYW1wYXJhZG9zIHBlbGEgCnVuaXZlcnNpZGFkZS4gRGV2aWRvIGFvcyBkaWZlcmVudGVzIHByb2Nlc3NvcyBwZWxvIHF1YWwgYSBzdWJtaXNz77+9byAKcG9kZSBvY29ycmVyLCBvIHJlcG9zaXTvv71yaW8gcGVybWl0ZSBhIGFjZWl0Ye+/ve+/vW8gZGEgbGljZW7vv71hIHBvciAKdGVyY2Vpcm9zLCBzb21lbnRlIG5vcyBjYXNvcyBkZSBkb2N1bWVudG9zIHByb2R1emlkb3MgcG9yIGludGVncmFudGVzIApkYSBVRkJBIGUgc3VibWV0aWRvcyBwb3IgcGVzc29hcyBhbXBhcmFkYXMgcG9yIGVzdGEgaW5zdGl0dWnvv73vv71vLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-10-18T01:37:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
title HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis
spellingShingle HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis
Lyra, André Castro
Acute hepatitis
Hepatitis E
TTV
GBV-C/HGV
Genotype
Brazil
title_short HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis
title_full HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis
title_fullStr HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis
title_full_unstemmed HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis
title_sort HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis
author Lyra, André Castro
author_facet Lyra, André Castro
Pinho, João Renato Rebello
Silva, L.K.
Sousa, L.
Saraceni, C. P.
Braga, Eduardo Lorens
Pereira, J. E.
Zarife, Maria Alice Sant'anna
Lyra, Luiz Guilherme Costa
author_role author
author2 Pinho, João Renato Rebello
Silva, L.K.
Sousa, L.
Saraceni, C. P.
Braga, Eduardo Lorens
Pereira, J. E.
Zarife, Maria Alice Sant'anna
Lyra, Luiz Guilherme Costa
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lyra, André Castro
Pinho, João Renato Rebello
Silva, L.K.
Sousa, L.
Saraceni, C. P.
Braga, Eduardo Lorens
Pereira, J. E.
Zarife, Maria Alice Sant'anna
Lyra, Luiz Guilherme Costa
Lyra, André Castro
Pinho, João Renato Rebello
Silva, L.K.
Sousa, L.
Saraceni, C. P.
Braga, Eduardo Lorens
Pereira, J. E.
Zarife, Maria Alice Sant'anna
Lyra, Luiz Guilherme Costa
dc.subject.por.fl_str_mv Acute hepatitis
Hepatitis E
TTV
GBV-C/HGV
Genotype
Brazil
topic Acute hepatitis
Hepatitis E
TTV
GBV-C/HGV
Genotype
Brazil
description p. 767-775
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2012-07-30T19:51:39Z
dc.date.available.fl_str_mv 2012-07-30T19:51:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6508
dc.identifier.issn.none.fl_str_mv 0100-879X
dc.identifier.number.pt_BR.fl_str_mv v. 38, n. 5
identifier_str_mv 0100-879X
v. 38, n. 5
url http://www.repositorio.ufba.br/ri/handle/ri/6508
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Scielo
publisher.none.fl_str_mv Scielo
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2005000500015
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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