Effects of imiquimod and low-intensity laser (λ660nm) in chemically induced oral carcinomas in hamster buccal pouch mucosa

Detalhes bibliográficos
Autor(a) principal: Monteiro, Juliana S. de C.
Data de Publicação: 2013
Outros Autores: Oliveira, Susana C. P. S. de, Reis Júnior, João Alves, Gurgel, Clarissa Araújo Silva, Souza, Suzana C. O. Machado de, Pinheiro, Antonio Luiz Barbosa, Santos, Jean Nunes dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13404
Resumo: Texto completo. Acesso restrito. p. 1017-1024
id UFBA-2_b6533c237ea62465bc21a7c6cbb063d1
oai_identifier_str oai:repositorio.ufba.br:ri/13404
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Monteiro, Juliana S. de C.Oliveira, Susana C. P. S. deReis Júnior, João AlvesGurgel, Clarissa Araújo SilvaSouza, Suzana C. O. Machado dePinheiro, Antonio Luiz BarbosaSantos, Jean Nunes dosMonteiro, Juliana S. de C.Oliveira, Susana C. P. S. deReis Júnior, João AlvesGurgel, Clarissa Araújo SilvaSouza, Suzana C. O. Machado dePinheiro, Antonio Luiz BarbosaSantos, Jean Nunes dos2013-10-31T17:44:17Z20130268-8921http://repositorio.ufba.br/ri/handle/ri/13404v. 28, n. 3Texto completo. Acesso restrito. p. 1017-1024Squamous cell carcinoma (SCC) is the most common neoplasm of the oral cavity. It is aggressive, highly proliferative, and metastatic. This study aimed to evaluate the effect of LLLT and imiquimod on DMBA chemically induced lesions on the oral mucosa of hamsters. SCCs were induced on 25 hamsters. Animals ofG1 (control 1)were killed and the presence of tumors confirmed; G2 (control 2) suffered no interventions for additional 4 weeks; animals of G3 (laser treatment) were irradiated (λ660nm, 50 mW, CW, Ø03 mm, 0.07 cm2, 714.2 mW/cm2, 133 s, 95 J/cm2, 6.65 J) at every other day for 4 weeks; animals of G4 (imiquimod treatment) received 5 % imiquimod three times a week for 4 weeks; and animals of G5 (imiquimod and laser treatment) received both treatments for the same period. Samples were taken and underwent histological analysis by light microscopy and were investigated using immunohistochemistry for S-100+ dendritic cells. In G1, G2, and G3, the evaluations showed malignant tumors and the absence of S-100+ dendritic cells in the tumor stroma. In G4, 60 % of the animals had no malignant tumors, and S-100+ dendritic cells were present in the stroma of the tumors as well as dysplasia. In G5, 40 % of the animals presented SCC, with scarce or no S-100+ dendritic cells. The imiquimod treatment played a direct effect on SCC, demonstrated by the increased number of S-100+ dendritic cells, which could suggest an important role of immune surveillance against neoplastic proliferation. Furthermore, its association with laser needs to be further investigated.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-06-12T20:06:16Z No. of bitstreams: 1 33333333333333.pdf: 714859 bytes, checksum: f47a06f3f3be8fa5b8a729848e7bc215 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T17:44:17Z (GMT) No. of bitstreams: 1 33333333333333.pdf: 714859 bytes, checksum: f47a06f3f3be8fa5b8a729848e7bc215 (MD5)Made available in DSpace on 2013-10-31T17:44:17Z (GMT). No. of bitstreams: 1 33333333333333.pdf: 714859 bytes, checksum: f47a06f3f3be8fa5b8a729848e7bc215 (MD5) Previous issue date: 2013SalvadorLasers in Medical Science10.1007/s10103-012-1192-2reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBADiode laserSquamous cell carcinomaChemical carcinogenesisImiquimodEffects of imiquimod and low-intensity laser (λ660nm) in chemically induced oral carcinomas in hamster buccal pouch mucosaLasers in Medical Scienceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL33333333333333.pdf33333333333333.pdfapplication/pdf714859https://repositorio.ufba.br/bitstream/ri/13404/1/33333333333333.pdff47a06f3f3be8fa5b8a729848e7bc215MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13404/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT33333333333333.pdf.txt33333333333333.pdf.txtExtracted texttext/plain35454https://repositorio.ufba.br/bitstream/ri/13404/3/33333333333333.pdf.txt09b52f3f66a317b165c33e799a8c990bMD53ri/134042022-07-05 14:04:04.59oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:04Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Effects of imiquimod and low-intensity laser (λ660nm) in chemically induced oral carcinomas in hamster buccal pouch mucosa
dc.title.alternative.pt_BR.fl_str_mv Lasers in Medical Science
title Effects of imiquimod and low-intensity laser (λ660nm) in chemically induced oral carcinomas in hamster buccal pouch mucosa
spellingShingle Effects of imiquimod and low-intensity laser (λ660nm) in chemically induced oral carcinomas in hamster buccal pouch mucosa
Monteiro, Juliana S. de C.
Diode laser
Squamous cell carcinoma
Chemical carcinogenesis
Imiquimod
title_short Effects of imiquimod and low-intensity laser (λ660nm) in chemically induced oral carcinomas in hamster buccal pouch mucosa
title_full Effects of imiquimod and low-intensity laser (λ660nm) in chemically induced oral carcinomas in hamster buccal pouch mucosa
title_fullStr Effects of imiquimod and low-intensity laser (λ660nm) in chemically induced oral carcinomas in hamster buccal pouch mucosa
title_full_unstemmed Effects of imiquimod and low-intensity laser (λ660nm) in chemically induced oral carcinomas in hamster buccal pouch mucosa
title_sort Effects of imiquimod and low-intensity laser (λ660nm) in chemically induced oral carcinomas in hamster buccal pouch mucosa
author Monteiro, Juliana S. de C.
author_facet Monteiro, Juliana S. de C.
Oliveira, Susana C. P. S. de
Reis Júnior, João Alves
Gurgel, Clarissa Araújo Silva
Souza, Suzana C. O. Machado de
Pinheiro, Antonio Luiz Barbosa
Santos, Jean Nunes dos
author_role author
author2 Oliveira, Susana C. P. S. de
Reis Júnior, João Alves
Gurgel, Clarissa Araújo Silva
Souza, Suzana C. O. Machado de
Pinheiro, Antonio Luiz Barbosa
Santos, Jean Nunes dos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Monteiro, Juliana S. de C.
Oliveira, Susana C. P. S. de
Reis Júnior, João Alves
Gurgel, Clarissa Araújo Silva
Souza, Suzana C. O. Machado de
Pinheiro, Antonio Luiz Barbosa
Santos, Jean Nunes dos
Monteiro, Juliana S. de C.
Oliveira, Susana C. P. S. de
Reis Júnior, João Alves
Gurgel, Clarissa Araújo Silva
Souza, Suzana C. O. Machado de
Pinheiro, Antonio Luiz Barbosa
Santos, Jean Nunes dos
dc.subject.por.fl_str_mv Diode laser
Squamous cell carcinoma
Chemical carcinogenesis
Imiquimod
topic Diode laser
Squamous cell carcinoma
Chemical carcinogenesis
Imiquimod
description Texto completo. Acesso restrito. p. 1017-1024
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-10-31T17:44:17Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13404
dc.identifier.issn.none.fl_str_mv 0268-8921
dc.identifier.number.pt_BR.fl_str_mv v. 28, n. 3
identifier_str_mv 0268-8921
v. 28, n. 3
url http://repositorio.ufba.br/ri/handle/ri/13404
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lasers in Medical Science
publisher.none.fl_str_mv Lasers in Medical Science
dc.source.pt_BR.fl_str_mv 10.1007/s10103-012-1192-2
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/13404/1/33333333333333.pdf
https://repositorio.ufba.br/bitstream/ri/13404/2/license.txt
https://repositorio.ufba.br/bitstream/ri/13404/3/33333333333333.pdf.txt
bitstream.checksum.fl_str_mv f47a06f3f3be8fa5b8a729848e7bc215
1b89a9a0548218172d7c829f87a0eab9
09b52f3f66a317b165c33e799a8c990b
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459448399691776