Does high-sensitivity C-reactive protein add prognostic value to the TIMI-Risk Score in individuals with non-ST elevation acute coronary syndromes?
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/6263 |
Resumo: | RESTRITO |
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Correia, Luis Cláudio LemosLima, José CarlosRocha, Mário S.D'Oliveira Junior, ArgemiroEsteves, José PériclesCorreia, Luis Cláudio LemosLima, José CarlosRocha, Mário S.D'Oliveira Junior, ArgemiroEsteves, José Péricles2012-06-29T15:18:26Z2012-06-29T15:18:26Z20070009-8981http://www.repositorio.ufba.br/ri/handle/ri/6263RESTRITOBackground: C-reactive protein (CRP) measured at hospital arrival of patients with non-ST elevation acute coronary syndromes (ACS) may add prognostic information to the TIMI-Risk Score. Methods: Eighty-six consecutive patients admitted with unstable angina or non-ST-elevation acute myocardial infarction and symptoms onset within the prior 48 h were included. Recurrent cardiovascular events during hospitalization were defined as non-fatal myocardial infarction or death. Serum CRP was measured immediately at hospital arrival and its prognostic value in relation to in-hospital cardiovascular events was tested by the area under the ROC curve and adjusted for TIMI risk predictors by logistic regression analysis. In addition, a CRP modified TIMI-Risk score was created by adding 2 points if CRP greater than the cut-off proposed by the ROC curve analysis. The accuracy of this new score was compared with the usual TIMI-Risk Score. Results: A significant predictive value of CRP in relation to in-hospital cardiovascular events was indicated by an area under the ROC curve of 0.80 (95% CI=0.66 to 0.93, p=0.009). C-reactive protein cut-off point of best prognostic performance was 7.2 mg/l. In the multivariate analysis, increased CRP (N7.2 mg/l) remained a significant predictor of events after adjustment for TIMI risk predictors (OR=14; 95% CI=1.6–121; p=0.018). The area under the ROC curve for the TIMI-Risk Score was 0.87 (95% CI=0.76–0.99, p=0.001). The addition of CRP to the TIMIRisk Score improved its prognostic value (area under the ROC curve=0.93; 95% CI=0.87–0.99, pb0.001). The additional value of the new score is demonstrated by a higher specificity (86% vs. 63%, pb0.001) and positive predictive value (39% vs. 19%) in relation to the TIMI-Risk Score. Conclusions: CRP measured at admission of patients with non-ST-elevation acute coronary syndromes adds prognostic information to the TIMIRisk Score. Additionally, the incorporation of this variable into the TIMI-Risk Score calculation is an effective manner to utilize CRP for risk stratification.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-06-29T15:18:26Z No. of bitstreams: 1 WWW1540.pdf: 320297 bytes, checksum: a1e00df0fabfb90ebd187512d891a029 (MD5)Made available in DSpace on 2012-06-29T15:18:26Z (GMT). No. of bitstreams: 1 WWW1540.pdf: 320297 bytes, checksum: a1e00df0fabfb90ebd187512d891a029 (MD5) Previous issue date: 2006SalvadorClinica Chimica Actahttp://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.cca.2006.06.026reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBATIMI-Risk ScoreC-reactive proteinAcute myocardial infarctionUnstable anginaDoes high-sensitivity C-reactive protein add prognostic value to the TIMI-Risk Score in individuals with non-ST elevation acute coronary syndromes?Clinica Chimica Actainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALWWW1540.pdfWWW1540.pdfapplication/pdf320297https://repositorio.ufba.br/bitstream/ri/6263/1/WWW1540.pdfa1e00df0fabfb90ebd187512d891a029MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6263/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTWWW1540.pdf.txtWWW1540.pdf.txtExtracted texttext/plain25491https://repositorio.ufba.br/bitstream/ri/6263/3/WWW1540.pdf.txtf17b48d2571e86ab80bcb36b374f80c3MD53ri/62632022-10-07 15:56:50.033oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-10-07T18:56:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Does high-sensitivity C-reactive protein add prognostic value to the TIMI-Risk Score in individuals with non-ST elevation acute coronary syndromes? |
dc.title.alternative.pt_BR.fl_str_mv |
Clinica Chimica Acta |
title |
Does high-sensitivity C-reactive protein add prognostic value to the TIMI-Risk Score in individuals with non-ST elevation acute coronary syndromes? |
spellingShingle |
Does high-sensitivity C-reactive protein add prognostic value to the TIMI-Risk Score in individuals with non-ST elevation acute coronary syndromes? Correia, Luis Cláudio Lemos TIMI-Risk Score C-reactive protein Acute myocardial infarction Unstable angina |
title_short |
Does high-sensitivity C-reactive protein add prognostic value to the TIMI-Risk Score in individuals with non-ST elevation acute coronary syndromes? |
title_full |
Does high-sensitivity C-reactive protein add prognostic value to the TIMI-Risk Score in individuals with non-ST elevation acute coronary syndromes? |
title_fullStr |
Does high-sensitivity C-reactive protein add prognostic value to the TIMI-Risk Score in individuals with non-ST elevation acute coronary syndromes? |
title_full_unstemmed |
Does high-sensitivity C-reactive protein add prognostic value to the TIMI-Risk Score in individuals with non-ST elevation acute coronary syndromes? |
title_sort |
Does high-sensitivity C-reactive protein add prognostic value to the TIMI-Risk Score in individuals with non-ST elevation acute coronary syndromes? |
author |
Correia, Luis Cláudio Lemos |
author_facet |
Correia, Luis Cláudio Lemos Lima, José Carlos Rocha, Mário S. D'Oliveira Junior, Argemiro Esteves, José Péricles |
author_role |
author |
author2 |
Lima, José Carlos Rocha, Mário S. D'Oliveira Junior, Argemiro Esteves, José Péricles |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Correia, Luis Cláudio Lemos Lima, José Carlos Rocha, Mário S. D'Oliveira Junior, Argemiro Esteves, José Péricles Correia, Luis Cláudio Lemos Lima, José Carlos Rocha, Mário S. D'Oliveira Junior, Argemiro Esteves, José Péricles |
dc.subject.por.fl_str_mv |
TIMI-Risk Score C-reactive protein Acute myocardial infarction Unstable angina |
topic |
TIMI-Risk Score C-reactive protein Acute myocardial infarction Unstable angina |
description |
RESTRITO |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2012-06-29T15:18:26Z |
dc.date.available.fl_str_mv |
2012-06-29T15:18:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/6263 |
dc.identifier.issn.none.fl_str_mv |
0009-8981 |
identifier_str_mv |
0009-8981 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/6263 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Clinica Chimica Acta |
publisher.none.fl_str_mv |
Clinica Chimica Acta |
dc.source.pt_BR.fl_str_mv |
http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.cca.2006.06.026 |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
instacron_str |
UFBA |
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UFBA |
reponame_str |
Repositório Institucional da UFBA |
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Repositório Institucional da UFBA |
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