Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia

Detalhes bibliográficos
Autor(a) principal: Matos, Eliana Dias
Data de Publicação: 2007
Outros Autores: Lemos, Antônio Carlos Moreira, Bittencourt, Carolina Nunes, Mesquita, Cristiane Leite
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16000
Resumo: Texto completo: acesso restrito. p. 331-338
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spelling Matos, Eliana DiasLemos, Antônio Carlos MoreiraBittencourt, Carolina NunesMesquita, Cristiane LeiteMatos, Eliana DiasLemos, Antônio Carlos MoreiraBittencourt, Carolina NunesMesquita, Cristiane Leite2014-09-09T16:09:10Z20071413-8670http://repositorio.ufba.br/ri/handle/ri/16000v. 11, n. 3Texto completo: acesso restrito. p. 331-338Anti-tuberculosis drug resistance, particularly multiresistance, is a crucial issue in the control of tuberculosis (TB). This study estimated the prevalence of primary and acquired anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from hospitalized patients, to identify the risk factors for resistance, and to evaluate the its impact on hospital mortality for tuberculosis. Strains of Mycobacterium tuberculosis from 217 patients hospitalized for TB were analyzed. Subjects were recruited sequentially at a TB reference hospital in Salvador, Bahia, Brazil from July 2001 to July 2003. Multiresistant (MR) strains were defined as strains resistant to rifampicin and isoniazid. Of a total of 217 strains isolated, 41 (19.0%, 95%CI: 14.1-24.5%) were resistant to at least one drug. Prevalence of primary resistance was 7.0% (10/145), while a prevalence of 43.1% (31/72) was found for acquired resistance. Primary resistance to one drug alone was found in 2.1% (3/145) and acquired monoresistance in 5.6% (4/72). Prevalence of MR strains in general was 14.3% (31/217), of which 4.2% (6/145) consisted of primary MR and 34.7% (25/72) of acquired MR. Three strains showed resistance to more than one drug, but were not classified as MR. In the multivariate analysis, abandoning treatment remained strongly associated with resistance (adjusted OR: 7.21; 95%CI: 3.27-15.90; p<0.001) following adjustment for 3 potential confounders (gender, alcohol dependence and HIV-infection). An association was found between resistance and mortality from tuberculosis, even after adjustment for HIV status, age, sex and alcohol dependence (adjusted OR: 7.13; 95%CI: 2.25-22.57; p<0.001). High prevalences of resistance, principally acquired resistance including MR, were found in patients hospitalized for TB in Bahia. This finding was strongly associated with having abandoned treatment, and confirmed the need to standardize the procedure for requesting sensitivity tests in this population at the time of hospital admission.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-24T13:52:28Z No. of bitstreams: 1 1413-86702007000300007.pdf: 52031 bytes, checksum: 8cf8f1c9cc2e1b8da3c0867b19c8f6b9 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T16:09:10Z (GMT) No. of bitstreams: 1 1413-86702007000300007.pdf: 52031 bytes, checksum: 8cf8f1c9cc2e1b8da3c0867b19c8f6b9 (MD5)Made available in DSpace on 2014-09-09T16:09:10Z (GMT). No. of bitstreams: 1 1413-86702007000300007.pdf: 52031 bytes, checksum: 8cf8f1c9cc2e1b8da3c0867b19c8f6b9 (MD5) Previous issue date: 2007http://dx.doi.org/10.1590/S1413-86702007000300007reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMycobacterium tuberculosisTuberculosisResistanceMultiresistanceHospitalsBahia-BrazilAnti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in BahiaBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1413-86702007000300007.pdf1413-86702007000300007.pdfapplication/pdf52031https://repositorio.ufba.br/bitstream/ri/16000/1/1413-86702007000300007.pdf8cf8f1c9cc2e1b8da3c0867b19c8f6b9MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16000/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT1413-86702007000300007.pdf.txt1413-86702007000300007.pdf.txtExtracted texttext/plain40001https://repositorio.ufba.br/bitstream/ri/16000/3/1413-86702007000300007.pdf.txt423417b8f1bd8f7204aeda39fc21899aMD53ri/160002022-07-05 14:03:36.15oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:36Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Infectious Diseases
title Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia
spellingShingle Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia
Matos, Eliana Dias
Mycobacterium tuberculosis
Tuberculosis
Resistance
Multiresistance
Hospitals
Bahia-Brazil
title_short Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia
title_full Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia
title_fullStr Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia
title_full_unstemmed Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia
title_sort Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia
author Matos, Eliana Dias
author_facet Matos, Eliana Dias
Lemos, Antônio Carlos Moreira
Bittencourt, Carolina Nunes
Mesquita, Cristiane Leite
author_role author
author2 Lemos, Antônio Carlos Moreira
Bittencourt, Carolina Nunes
Mesquita, Cristiane Leite
author2_role author
author
author
dc.contributor.author.fl_str_mv Matos, Eliana Dias
Lemos, Antônio Carlos Moreira
Bittencourt, Carolina Nunes
Mesquita, Cristiane Leite
Matos, Eliana Dias
Lemos, Antônio Carlos Moreira
Bittencourt, Carolina Nunes
Mesquita, Cristiane Leite
dc.subject.por.fl_str_mv Mycobacterium tuberculosis
Tuberculosis
Resistance
Multiresistance
Hospitals
Bahia-Brazil
topic Mycobacterium tuberculosis
Tuberculosis
Resistance
Multiresistance
Hospitals
Bahia-Brazil
description Texto completo: acesso restrito. p. 331-338
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-09-09T16:09:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16000
dc.identifier.issn.none.fl_str_mv 1413-8670
dc.identifier.number.pt_BR.fl_str_mv v. 11, n. 3
identifier_str_mv 1413-8670
v. 11, n. 3
url http://repositorio.ufba.br/ri/handle/ri/16000
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S1413-86702007000300007
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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