Meta-analysis about efficacy of anti-resorptive drugs in post-menopausal osteoporosis

Detalhes bibliográficos
Autor(a) principal: Macedo, Jeane Meire Sales de
Data de Publicação: 1998
Outros Autores: Macedo, Cristiano Ricardo Bastos de, Elkis, Helio, Oliveira, I. R. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8192
Resumo: Texto completo: acesso restrito. p.345–352
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spelling Macedo, Jeane Meire Sales deMacedo, Cristiano Ricardo Bastos deElkis, HelioOliveira, I. R. deMacedo, Jeane Meire Sales deMacedo, Cristiano Ricardo Bastos deElkis, HelioOliveira, I. R. de2013-01-28T14:57:07Z19980269-4727http://www.repositorio.ufba.br/ri/handle/ri/8192v. 23, n. 5Texto completo: acesso restrito. p.345–352Objective: The purpose of this study was to compare the effect of three groups of anti-resorptive drugs in post-menopausal osteoporosis. Data sources: We collected data covering the period between 1983 and 1995, by first using MEDLINE. References retrieved were scanned further to identify additional papers. Study selection: Only randomized studies evaluating bone mass by means of dual-photon or dual energy densitometry over a period of 1 year were accepted. Data extraction: Studies were arranged into three drug groups. We used densitometry results after 1 year in all treatment or control groups. Factors which might interfere with the results were recorded for subsequent separate analysis. Data synthesis: The MEDLINE search identified almost 25,000 studies. On reading the abstracts, 275 trials appeared to be controlled trials and original copies were retrieved for detailed analysis. A total of 31 articles which satisfied the inclusion criteria were identified. The first meta-analysis included studies which compared oestrogens and placebo, and the global effect-size was 0·54 (95% CI 0·34, 0·73). The second meta-analysis compared calcitonins with placebo and produced an effect-size of 0·41 (95% CI 0·21, 0·61) The third analysis compared bisphosphonates and placebo and showed an effect-size of 0·87 (95% CI 0·68, 1·07). Only oestrogen dose affected the results found. Conclusions: Bisphosphonates had the greatest effect on bone mass in post-menopausal osteoporosis.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-28T14:57:07Z No. of bitstreams: 1 Macedo.pdf: 322808 bytes, checksum: f572799517326422635af7118e8aca98 (MD5)Made available in DSpace on 2013-01-28T14:57:07Z (GMT). No. of bitstreams: 1 Macedo.pdf: 322808 bytes, checksum: f572799517326422635af7118e8aca98 (MD5) Previous issue date: 1998http://dx.doi.org/10.1046/j.1365-2710.1998.00168.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMeta-analysis about efficacy of anti-resorptive drugs in post-menopausal osteoporosisJournal of Clinical Pharmacy and Therapeuticsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALMacedo.pdfMacedo.pdfapplication/pdf322808https://repositorio.ufba.br/bitstream/ri/8192/1/Macedo.pdff572799517326422635af7118e8aca98MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8192/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ri/81922022-07-05 14:03:08.675oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:08Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Meta-analysis about efficacy of anti-resorptive drugs in post-menopausal osteoporosis
dc.title.alternative.pt_BR.fl_str_mv Journal of Clinical Pharmacy and Therapeutics
title Meta-analysis about efficacy of anti-resorptive drugs in post-menopausal osteoporosis
spellingShingle Meta-analysis about efficacy of anti-resorptive drugs in post-menopausal osteoporosis
Macedo, Jeane Meire Sales de
title_short Meta-analysis about efficacy of anti-resorptive drugs in post-menopausal osteoporosis
title_full Meta-analysis about efficacy of anti-resorptive drugs in post-menopausal osteoporosis
title_fullStr Meta-analysis about efficacy of anti-resorptive drugs in post-menopausal osteoporosis
title_full_unstemmed Meta-analysis about efficacy of anti-resorptive drugs in post-menopausal osteoporosis
title_sort Meta-analysis about efficacy of anti-resorptive drugs in post-menopausal osteoporosis
author Macedo, Jeane Meire Sales de
author_facet Macedo, Jeane Meire Sales de
Macedo, Cristiano Ricardo Bastos de
Elkis, Helio
Oliveira, I. R. de
author_role author
author2 Macedo, Cristiano Ricardo Bastos de
Elkis, Helio
Oliveira, I. R. de
author2_role author
author
author
dc.contributor.author.fl_str_mv Macedo, Jeane Meire Sales de
Macedo, Cristiano Ricardo Bastos de
Elkis, Helio
Oliveira, I. R. de
Macedo, Jeane Meire Sales de
Macedo, Cristiano Ricardo Bastos de
Elkis, Helio
Oliveira, I. R. de
description Texto completo: acesso restrito. p.345–352
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2013-01-28T14:57:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8192
dc.identifier.issn.none.fl_str_mv 0269-4727
dc.identifier.number.pt_BR.fl_str_mv v. 23, n. 5
identifier_str_mv 0269-4727
v. 23, n. 5
url http://www.repositorio.ufba.br/ri/handle/ri/8192
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1046/j.1365-2710.1998.00168.x
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institution UFBA
reponame_str Repositório Institucional da UFBA
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