Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives

Detalhes bibliográficos
Autor(a) principal: Melo, Ailton de Souza
Data de Publicação: 2011
Outros Autores: Monteiro, Larissa, Lima, Rute Maria Ferreira, Oliveira, Diêgo Madureira de, Cerqueira, Martins Dias de, El-Bachá, Ramon dos Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/20785
Resumo: The incidence and prevalence of neurodegenerative diseases (ND) increase with life expectancy. This paper reviews the role of oxidative stress (OS) in ND and pharmacological attempts to fight against reactive oxygen species (ROS)-induced neurodegeneration. Several mechanisms involved in ROS generation in neurodegeneration have been proposed. Recent articles about molecular pathways involved in ROS generation were reviewed. The progress in the development of neuroprotective therapies has been hampered because it is difficult to define targets for treatment and determine what should be considered as neuroprotective. Therefore, the attention was focused on researches about pharmacological targets that could protect neurons against OS. Since it is necessary to look for genes as the ultimate controllers of all biological processes, this paper also tried to identify gerontogenes involved in OS and neurodegeneration. Since neurons depend on glial cells to survive, recent articles about the functioning of these cells in aging and ND were also reviewed. Finally, clinical trials testing potential neuroprotective agents were critically reviewed. Although several potential drugs have been screened in in vitro and in vivo models of ND, these results were not translated in benefit of patients, and disappointing results were obtained in the majority of clinical trials.
id UFBA-2_ca002d6ebad7bd7e242e0a20644cb863
oai_identifier_str oai:repositorio.ufba.br:ri/20785
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Melo, Ailton de SouzaMonteiro, LarissaLima, Rute Maria FerreiraOliveira, Diêgo Madureira deCerqueira, Martins Dias deEl-Bachá, Ramon dos SantosMelo, Ailton de SouzaMonteiro, LarissaLima, Rute Maria FerreiraOliveira, Diêgo Madureira deCerqueira, Martins Dias deEl-Bachá, Ramon dos Santos2016-10-07T12:41:31Z2016-10-07T12:41:31Z2011Melo e col., 2011http://repositorio.ufba.br/ri/handle/ri/20785v. 2011The incidence and prevalence of neurodegenerative diseases (ND) increase with life expectancy. This paper reviews the role of oxidative stress (OS) in ND and pharmacological attempts to fight against reactive oxygen species (ROS)-induced neurodegeneration. Several mechanisms involved in ROS generation in neurodegeneration have been proposed. Recent articles about molecular pathways involved in ROS generation were reviewed. The progress in the development of neuroprotective therapies has been hampered because it is difficult to define targets for treatment and determine what should be considered as neuroprotective. Therefore, the attention was focused on researches about pharmacological targets that could protect neurons against OS. Since it is necessary to look for genes as the ultimate controllers of all biological processes, this paper also tried to identify gerontogenes involved in OS and neurodegeneration. Since neurons depend on glial cells to survive, recent articles about the functioning of these cells in aging and ND were also reviewed. Finally, clinical trials testing potential neuroprotective agents were critically reviewed. Although several potential drugs have been screened in in vitro and in vivo models of ND, these results were not translated in benefit of patients, and disappointing results were obtained in the majority of clinical trials.Submitted by Ramon El-Bachá (ramon@ufba.br) on 2016-10-01T22:11:12Z No. of bitstreams: 1 Melo et al 2011.pdf: 2735529 bytes, checksum: af9db5c06681334d8a7a23b30ccaf010 (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2016-10-07T12:41:31Z (GMT) No. of bitstreams: 1 Melo et al 2011.pdf: 2735529 bytes, checksum: af9db5c06681334d8a7a23b30ccaf010 (MD5)Made available in DSpace on 2016-10-07T12:41:31Z (GMT). No. of bitstreams: 1 Melo et al 2011.pdf: 2735529 bytes, checksum: af9db5c06681334d8a7a23b30ccaf010 (MD5) Previous issue date: 2011CNPq/CAPESHindawi Publishing CorporationDOI: 10.1155/2011/467180reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAOxidative StressNeurodegenerative DiseasesTherapeutic PerspectivesOxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectivesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengORIGINALMelo et al 2011.pdfMelo et al 2011.pdfapplication/pdf2735529https://repositorio.ufba.br/bitstream/ri/20785/1/Melo%20et%20al%202011.pdfaf9db5c06681334d8a7a23b30ccaf010MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/20785/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTMelo et al 2011.pdf.txtMelo et al 2011.pdf.txtExtracted texttext/plain83946https://repositorio.ufba.br/bitstream/ri/20785/3/Melo%20et%20al%202011.pdf.txt8a67d1abf6c635fcde4024b04d4b95ccMD53ri/207852022-08-08 13:19:03.983oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:19:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives
title Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives
spellingShingle Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives
Melo, Ailton de Souza
Oxidative Stress
Neurodegenerative Diseases
Therapeutic Perspectives
title_short Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives
title_full Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives
title_fullStr Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives
title_full_unstemmed Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives
title_sort Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives
author Melo, Ailton de Souza
author_facet Melo, Ailton de Souza
Monteiro, Larissa
Lima, Rute Maria Ferreira
Oliveira, Diêgo Madureira de
Cerqueira, Martins Dias de
El-Bachá, Ramon dos Santos
author_role author
author2 Monteiro, Larissa
Lima, Rute Maria Ferreira
Oliveira, Diêgo Madureira de
Cerqueira, Martins Dias de
El-Bachá, Ramon dos Santos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Melo, Ailton de Souza
Monteiro, Larissa
Lima, Rute Maria Ferreira
Oliveira, Diêgo Madureira de
Cerqueira, Martins Dias de
El-Bachá, Ramon dos Santos
Melo, Ailton de Souza
Monteiro, Larissa
Lima, Rute Maria Ferreira
Oliveira, Diêgo Madureira de
Cerqueira, Martins Dias de
El-Bachá, Ramon dos Santos
dc.subject.por.fl_str_mv Oxidative Stress
Neurodegenerative Diseases
Therapeutic Perspectives
topic Oxidative Stress
Neurodegenerative Diseases
Therapeutic Perspectives
description The incidence and prevalence of neurodegenerative diseases (ND) increase with life expectancy. This paper reviews the role of oxidative stress (OS) in ND and pharmacological attempts to fight against reactive oxygen species (ROS)-induced neurodegeneration. Several mechanisms involved in ROS generation in neurodegeneration have been proposed. Recent articles about molecular pathways involved in ROS generation were reviewed. The progress in the development of neuroprotective therapies has been hampered because it is difficult to define targets for treatment and determine what should be considered as neuroprotective. Therefore, the attention was focused on researches about pharmacological targets that could protect neurons against OS. Since it is necessary to look for genes as the ultimate controllers of all biological processes, this paper also tried to identify gerontogenes involved in OS and neurodegeneration. Since neurons depend on glial cells to survive, recent articles about the functioning of these cells in aging and ND were also reviewed. Finally, clinical trials testing potential neuroprotective agents were critically reviewed. Although several potential drugs have been screened in in vitro and in vivo models of ND, these results were not translated in benefit of patients, and disappointing results were obtained in the majority of clinical trials.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2016-10-07T12:41:31Z
dc.date.available.fl_str_mv 2016-10-07T12:41:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Melo e col., 2011
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/20785
dc.identifier.number.pt_BR.fl_str_mv v. 2011
identifier_str_mv Melo e col., 2011
v. 2011
url http://repositorio.ufba.br/ri/handle/ri/20785
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.pt_BR.fl_str_mv DOI: 10.1155/2011/467180
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/20785/1/Melo%20et%20al%202011.pdf
https://repositorio.ufba.br/bitstream/ri/20785/2/license.txt
https://repositorio.ufba.br/bitstream/ri/20785/3/Melo%20et%20al%202011.pdf.txt
bitstream.checksum.fl_str_mv af9db5c06681334d8a7a23b30ccaf010
ff6eaa8b858ea317fded99f125f5fcd0
8a67d1abf6c635fcde4024b04d4b95cc
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459525778309120