Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/20785 |
Resumo: | The incidence and prevalence of neurodegenerative diseases (ND) increase with life expectancy. This paper reviews the role of oxidative stress (OS) in ND and pharmacological attempts to fight against reactive oxygen species (ROS)-induced neurodegeneration. Several mechanisms involved in ROS generation in neurodegeneration have been proposed. Recent articles about molecular pathways involved in ROS generation were reviewed. The progress in the development of neuroprotective therapies has been hampered because it is difficult to define targets for treatment and determine what should be considered as neuroprotective. Therefore, the attention was focused on researches about pharmacological targets that could protect neurons against OS. Since it is necessary to look for genes as the ultimate controllers of all biological processes, this paper also tried to identify gerontogenes involved in OS and neurodegeneration. Since neurons depend on glial cells to survive, recent articles about the functioning of these cells in aging and ND were also reviewed. Finally, clinical trials testing potential neuroprotective agents were critically reviewed. Although several potential drugs have been screened in in vitro and in vivo models of ND, these results were not translated in benefit of patients, and disappointing results were obtained in the majority of clinical trials. |
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Melo, Ailton de SouzaMonteiro, LarissaLima, Rute Maria FerreiraOliveira, Diêgo Madureira deCerqueira, Martins Dias deEl-Bachá, Ramon dos SantosMelo, Ailton de SouzaMonteiro, LarissaLima, Rute Maria FerreiraOliveira, Diêgo Madureira deCerqueira, Martins Dias deEl-Bachá, Ramon dos Santos2016-10-07T12:41:31Z2016-10-07T12:41:31Z2011Melo e col., 2011http://repositorio.ufba.br/ri/handle/ri/20785v. 2011The incidence and prevalence of neurodegenerative diseases (ND) increase with life expectancy. This paper reviews the role of oxidative stress (OS) in ND and pharmacological attempts to fight against reactive oxygen species (ROS)-induced neurodegeneration. Several mechanisms involved in ROS generation in neurodegeneration have been proposed. Recent articles about molecular pathways involved in ROS generation were reviewed. The progress in the development of neuroprotective therapies has been hampered because it is difficult to define targets for treatment and determine what should be considered as neuroprotective. Therefore, the attention was focused on researches about pharmacological targets that could protect neurons against OS. Since it is necessary to look for genes as the ultimate controllers of all biological processes, this paper also tried to identify gerontogenes involved in OS and neurodegeneration. Since neurons depend on glial cells to survive, recent articles about the functioning of these cells in aging and ND were also reviewed. Finally, clinical trials testing potential neuroprotective agents were critically reviewed. Although several potential drugs have been screened in in vitro and in vivo models of ND, these results were not translated in benefit of patients, and disappointing results were obtained in the majority of clinical trials.Submitted by Ramon El-Bachá (ramon@ufba.br) on 2016-10-01T22:11:12Z No. of bitstreams: 1 Melo et al 2011.pdf: 2735529 bytes, checksum: af9db5c06681334d8a7a23b30ccaf010 (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2016-10-07T12:41:31Z (GMT) No. of bitstreams: 1 Melo et al 2011.pdf: 2735529 bytes, checksum: af9db5c06681334d8a7a23b30ccaf010 (MD5)Made available in DSpace on 2016-10-07T12:41:31Z (GMT). No. of bitstreams: 1 Melo et al 2011.pdf: 2735529 bytes, checksum: af9db5c06681334d8a7a23b30ccaf010 (MD5) Previous issue date: 2011CNPq/CAPESHindawi Publishing CorporationDOI: 10.1155/2011/467180reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAOxidative StressNeurodegenerative DiseasesTherapeutic PerspectivesOxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectivesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengORIGINALMelo et al 2011.pdfMelo et al 2011.pdfapplication/pdf2735529https://repositorio.ufba.br/bitstream/ri/20785/1/Melo%20et%20al%202011.pdfaf9db5c06681334d8a7a23b30ccaf010MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/20785/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTMelo et al 2011.pdf.txtMelo et al 2011.pdf.txtExtracted texttext/plain83946https://repositorio.ufba.br/bitstream/ri/20785/3/Melo%20et%20al%202011.pdf.txt8a67d1abf6c635fcde4024b04d4b95ccMD53ri/207852022-08-08 13:19:03.983oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:19:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives |
title |
Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives |
spellingShingle |
Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives Melo, Ailton de Souza Oxidative Stress Neurodegenerative Diseases Therapeutic Perspectives |
title_short |
Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives |
title_full |
Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives |
title_fullStr |
Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives |
title_full_unstemmed |
Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives |
title_sort |
Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives |
author |
Melo, Ailton de Souza |
author_facet |
Melo, Ailton de Souza Monteiro, Larissa Lima, Rute Maria Ferreira Oliveira, Diêgo Madureira de Cerqueira, Martins Dias de El-Bachá, Ramon dos Santos |
author_role |
author |
author2 |
Monteiro, Larissa Lima, Rute Maria Ferreira Oliveira, Diêgo Madureira de Cerqueira, Martins Dias de El-Bachá, Ramon dos Santos |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Melo, Ailton de Souza Monteiro, Larissa Lima, Rute Maria Ferreira Oliveira, Diêgo Madureira de Cerqueira, Martins Dias de El-Bachá, Ramon dos Santos Melo, Ailton de Souza Monteiro, Larissa Lima, Rute Maria Ferreira Oliveira, Diêgo Madureira de Cerqueira, Martins Dias de El-Bachá, Ramon dos Santos |
dc.subject.por.fl_str_mv |
Oxidative Stress Neurodegenerative Diseases Therapeutic Perspectives |
topic |
Oxidative Stress Neurodegenerative Diseases Therapeutic Perspectives |
description |
The incidence and prevalence of neurodegenerative diseases (ND) increase with life expectancy. This paper reviews the role of oxidative stress (OS) in ND and pharmacological attempts to fight against reactive oxygen species (ROS)-induced neurodegeneration. Several mechanisms involved in ROS generation in neurodegeneration have been proposed. Recent articles about molecular pathways involved in ROS generation were reviewed. The progress in the development of neuroprotective therapies has been hampered because it is difficult to define targets for treatment and determine what should be considered as neuroprotective. Therefore, the attention was focused on researches about pharmacological targets that could protect neurons against OS. Since it is necessary to look for genes as the ultimate controllers of all biological processes, this paper also tried to identify gerontogenes involved in OS and neurodegeneration. Since neurons depend on glial cells to survive, recent articles about the functioning of these cells in aging and ND were also reviewed. Finally, clinical trials testing potential neuroprotective agents were critically reviewed. Although several potential drugs have been screened in in vitro and in vivo models of ND, these results were not translated in benefit of patients, and disappointing results were obtained in the majority of clinical trials. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2016-10-07T12:41:31Z |
dc.date.available.fl_str_mv |
2016-10-07T12:41:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Melo e col., 2011 |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/20785 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 2011 |
identifier_str_mv |
Melo e col., 2011 v. 2011 |
url |
http://repositorio.ufba.br/ri/handle/ri/20785 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.pt_BR.fl_str_mv |
DOI: 10.1155/2011/467180 |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
instname_str |
Universidade Federal da Bahia (UFBA) |
instacron_str |
UFBA |
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UFBA |
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Repositório Institucional da UFBA |
collection |
Repositório Institucional da UFBA |
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