Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets

Detalhes bibliográficos
Autor(a) principal: Peixinho, Solange
Data de Publicação: 2003
Outros Autores: Villar, Rosa M., Longo, José Gil, Daranas, Antonio H., Souto, Marı́a L., Fernández, José J., Barral, Miguel A., Santafé, Gilmar, Rodrı́guez, Jaime, Jiménez, Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14455
Resumo: Texto completo: acesso restrito. p. 2301–2306
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spelling Peixinho, SolangeVillar, Rosa M.Longo, José GilDaranas, Antonio H.Souto, Marı́a L.Fernández, José J.Barral, Miguel A.Santafé, GilmarRodrı́guez, JaimeJiménez, CarlosPeixinho, SolangeVillar, Rosa M.Longo, José GilDaranas, Antonio H.Souto, Marı́a L.Fernández, José J.Barral, Miguel A.Santafé, GilmarRodrı́guez, JaimeJiménez, Carlos2014-01-23T18:12:20Z20030968-0896http://repositorio.ufba.br/ri/handle/ri/14455v. 11, n. 10Texto completo: acesso restrito. p. 2301–2306Ten zoanthamine-type alkaloids from two marine zoanthids belonging to the Zoanthus genus (Zoanthus nymphaeus and Zoanthus sp.) along with one semisynthetic derivative were evaluated for their antiplatelet activities on human platelet aggregation induced by several stimulating agents. 11-Hydroxyzoanthamine (11) and a synthetic derivative of norzoanthamine (16) showed strong inhibition against thrombin-, collagen- and arachidonic acid-induced aggregation, zoanthenol (15) displayed a selective inhibitory activity induced by collagen, while zoanthaminone (10) behaved as a potent aggregant agent. These evaluations allowed us to deduce several structure–activity relationships and suggest some mechanisms of action for this type of compounds.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-01-06T13:26:16Z No. of bitstreams: 1 Solange Peixinho.pdf: 235112 bytes, checksum: a2221c770b372e015d944d4639a8752f (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-01-23T18:12:20Z (GMT) No. of bitstreams: 1 Solange Peixinho.pdf: 235112 bytes, checksum: a2221c770b372e015d944d4639a8752f (MD5)Made available in DSpace on 2014-01-23T18:12:20Z (GMT). No. of bitstreams: 1 Solange Peixinho.pdf: 235112 bytes, checksum: a2221c770b372e015d944d4639a8752f (MD5) Previous issue date: 2003http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/S0968-0896(03)00107-Xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAlcalóidesEvaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human plateletsBioorganic and Medicinal Chemistryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALSolange Peixinho.pdfSolange Peixinho.pdfapplication/pdf235112https://repositorio.ufba.br/bitstream/ri/14455/1/Solange%20Peixinho.pdfa2221c770b372e015d944d4639a8752fMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14455/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTSolange Peixinho.pdf.txtSolange Peixinho.pdf.txtExtracted texttext/plain27609https://repositorio.ufba.br/bitstream/ri/14455/3/Solange%20Peixinho.pdf.txt9e7ff8b613b542b1c47a294164f51aeaMD53ri/144552022-07-05 14:02:48.265oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:48Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets
dc.title.alternative.pt_BR.fl_str_mv Bioorganic and Medicinal Chemistry
title Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets
spellingShingle Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets
Peixinho, Solange
Alcalóides
title_short Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets
title_full Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets
title_fullStr Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets
title_full_unstemmed Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets
title_sort Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets
author Peixinho, Solange
author_facet Peixinho, Solange
Villar, Rosa M.
Longo, José Gil
Daranas, Antonio H.
Souto, Marı́a L.
Fernández, José J.
Barral, Miguel A.
Santafé, Gilmar
Rodrı́guez, Jaime
Jiménez, Carlos
author_role author
author2 Villar, Rosa M.
Longo, José Gil
Daranas, Antonio H.
Souto, Marı́a L.
Fernández, José J.
Barral, Miguel A.
Santafé, Gilmar
Rodrı́guez, Jaime
Jiménez, Carlos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Peixinho, Solange
Villar, Rosa M.
Longo, José Gil
Daranas, Antonio H.
Souto, Marı́a L.
Fernández, José J.
Barral, Miguel A.
Santafé, Gilmar
Rodrı́guez, Jaime
Jiménez, Carlos
Peixinho, Solange
Villar, Rosa M.
Longo, José Gil
Daranas, Antonio H.
Souto, Marı́a L.
Fernández, José J.
Barral, Miguel A.
Santafé, Gilmar
Rodrı́guez, Jaime
Jiménez, Carlos
dc.subject.por.fl_str_mv Alcalóides
topic Alcalóides
description Texto completo: acesso restrito. p. 2301–2306
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2014-01-23T18:12:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14455
dc.identifier.issn.none.fl_str_mv 0968-0896
dc.identifier.number.pt_BR.fl_str_mv v. 11, n. 10
identifier_str_mv 0968-0896
v. 11, n. 10
url http://repositorio.ufba.br/ri/handle/ri/14455
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/S0968-0896(03)00107-X
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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collection Repositório Institucional da UFBA
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