Gene encoding duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations

Detalhes bibliográficos
Autor(a) principal: Vergara, Candelaria
Data de Publicação: 2008
Outros Autores: Yuhjung, J. Tsai, Grant, Audrey V., Ponte, Eduardo Vieira, Cruz Filho, Álvaro Augusto Souza da, Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13933
Resumo: Texto completo: acesso restrito. p. 1017-1022
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spelling Vergara, CandelariaYuhjung, J. TsaiGrant, Audrey V.Ponte, Eduardo VieiraCruz Filho, Álvaro Augusto Souza daCarvalho Filho, Edgar Marcelino deVergara, CandelariaYuhjung, J. TsaiGrant, Audrey V.Ponte, Eduardo VieiraCruz Filho, Álvaro Augusto Souza daCarvalho Filho, Edgar Marcelino de2013-11-26T13:19:13Z20081073-449Xhttp://repositorio.ufba.br/ri/handle/ri/13933v. 178, n. 10Texto completo: acesso restrito. p. 1017-1022Rationale: Asthma prevalence and severity are high among underserved minorities, including those of African descent. The Duffy antigen/receptor for chemokines is the receptor for Plasmodium vivax on erythrocytes and functions as a chemokine-clearing receptor. Unlike European populations, decreased expression of the receptor on erythrocytes is common among populations of African descent, and results from a functional T-46C polymorphism (rs2814778) in the promoter. This variant provides an evolutionary advantage in malaria-endemic regions, because Duffy antigen/receptor for chemokines-negative erythrocytes are more resistant to infection by P. vivax. Objectives: To determine the role of the rs2814778 polymorphism in asthma and atopy as measured by total serum IgE levels among four populations of African descent (African Caribbean, African American, Brazilian, and Colombian) and a European American population. Methods: Family-based association tests were performed in each of the five populations to test for association between the rs2814778 polymorphism and asthma or total IgE concentration. Measurements and Main Results: Asthma was significantly associated with the rs2814778 polymorphism in the African Caribbean, Colombian, and Brazilian families (P < 0.05). High total IgE levels were associated with this variant in African Caribbean and Colombian families (P < 0.05). The variant allele was not polymorphic among European Americans. Conclusions: Susceptibility to asthma and atopy among certain populations of African descent is influenced by a functional polymorphism in the gene encoding Duffy antigen/receptor for chemokines. This genetic variant, which confers resistance to malarial parasitic infection, may also partially explain ethnic differences in morbidity of asthma.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-11-25T13:59:38Z No. of bitstreams: 1 rccm%2E200801-182oc.pdf: 524288 bytes, checksum: 60b8193f8f11541b541093254dafaf4d (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-26T13:19:13Z (GMT) No. of bitstreams: 1 rccm%2E200801-182oc.pdf: 524288 bytes, checksum: 60b8193f8f11541b541093254dafaf4d (MD5)Made available in DSpace on 2013-11-26T13:19:13Z (GMT). No. of bitstreams: 1 rccm%2E200801-182oc.pdf: 524288 bytes, checksum: 60b8193f8f11541b541093254dafaf4d (MD5) Previous issue date: 2008http://dx.doi.org/10.1164/rccm.200801-182OCreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBADuffy antigen/receptor for chemokinesContinental population groupsLung diseasesHypersensitivityGene encoding duffy antigen/receptor for chemokines is associated with asthma and IgE in three populationsAmerican Journal of Respiratory and Critical Care Medicineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALrccm%2E200801-182oc.pdfrccm%2E200801-182oc.pdfapplication/pdf524288https://repositorio.ufba.br/bitstream/ri/13933/1/rccm%252E200801-182oc.pdf60b8193f8f11541b541093254dafaf4dMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13933/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTrccm%2E200801-182oc.pdf.txtrccm%2E200801-182oc.pdf.txtExtracted texttext/plain37511https://repositorio.ufba.br/bitstream/ri/13933/3/rccm%252E200801-182oc.pdf.txt2c4589a6f1dd35ddd72e7feedc46100bMD53ri/139332022-07-05 14:02:58.549oai:repositorio.ufba.br:ri/13933VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBLgoKIFBlbG8gcHJvY2Vzc28gZGUgc3VibWlzc++/vW8gZGUgZG9jdW1lbnRvcywgbyBhdXRvciBvdSBzZXUgcmVwcmVzZW50YW50ZSBsZWdhbCwgYW8gYWNlaXRhciAKZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEsIGNvbmNlZGUgYW8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVuaXZlcnNpZGFkZSBGZWRlcmFsIGRhIEJhaGlhIApvIGRpcmVpdG8gZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCBkZSBwcmVzZXJ2Ye+/ve+/vW8uIApFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIGF1dG9yL2NvcHlyaWdodCwgbWFzIGVudGVuZGUgbyBkb2N1bWVudG8gCmNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4KCiBQYXJhIG9zIGRvY3VtZW50b3MgcHVibGljYWRvcyBjb20gcmVwYXNzZSBkZSBkaXJlaXRvcyBkZSBkaXN0cmlidWnvv73vv71vLCBlc3NlIHRlcm1vIGRlIGxpY2Vu77+9YSAKZW50ZW5kZSBxdWU6CgogTWFudGVuZG8gb3MgZGlyZWl0b3MgYXV0b3JhaXMsIHJlcGFzc2Fkb3MgYSB0ZXJjZWlyb3MsIGVtIGNhc28gZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8KcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIGludGVncmFsLCBtYXMgbGliZXJhIGFzIGluZm9ybWHvv73vv71lcyBzb2JyZSBvIGRvY3VtZW50bwooTWV0YWRhZG9zIGVzY3JpdGl2b3MpLgoKIERlc3RhIGZvcm1hLCBhdGVuZGVuZG8gYW9zIGFuc2Vpb3MgZGVzc2EgdW5pdmVyc2lkYWRlIGVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gCmFzIHJlc3Ryae+/ve+/vWVzIGltcG9zdGFzIHBlbG9zIGVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4KCiBQYXJhIGFzIHB1YmxpY2Hvv73vv71lcyBzZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgQWNlc3NvIEFiZXJ0bywgb3MgZGVw77+9c2l0b3MgCmNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gb3MgZGlyZWl0b3MgYXV0b3JhaXMsIG1hcyBtYW5077+9bSBhY2Vzc28gaXJyZXN0cml0byAKYW8gbWV0YWRhZG9zIGUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIGNvbnNlbnRpbWVudG8KIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgZXN0YXJlbSBlbSBpbmljaWF0aXZhcyBkZSBhY2Vzc28gYWJlcnRvLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:58Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Gene encoding duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations
dc.title.alternative.pt_BR.fl_str_mv American Journal of Respiratory and Critical Care Medicine
title Gene encoding duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations
spellingShingle Gene encoding duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations
Vergara, Candelaria
Duffy antigen/receptor for chemokines
Continental population groups
Lung diseases
Hypersensitivity
title_short Gene encoding duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations
title_full Gene encoding duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations
title_fullStr Gene encoding duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations
title_full_unstemmed Gene encoding duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations
title_sort Gene encoding duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations
author Vergara, Candelaria
author_facet Vergara, Candelaria
Yuhjung, J. Tsai
Grant, Audrey V.
Ponte, Eduardo Vieira
Cruz Filho, Álvaro Augusto Souza da
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Yuhjung, J. Tsai
Grant, Audrey V.
Ponte, Eduardo Vieira
Cruz Filho, Álvaro Augusto Souza da
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vergara, Candelaria
Yuhjung, J. Tsai
Grant, Audrey V.
Ponte, Eduardo Vieira
Cruz Filho, Álvaro Augusto Souza da
Carvalho Filho, Edgar Marcelino de
Vergara, Candelaria
Yuhjung, J. Tsai
Grant, Audrey V.
Ponte, Eduardo Vieira
Cruz Filho, Álvaro Augusto Souza da
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv Duffy antigen/receptor for chemokines
Continental population groups
Lung diseases
Hypersensitivity
topic Duffy antigen/receptor for chemokines
Continental population groups
Lung diseases
Hypersensitivity
description Texto completo: acesso restrito. p. 1017-1022
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-11-26T13:19:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13933
dc.identifier.issn.none.fl_str_mv 1073-449X
dc.identifier.number.pt_BR.fl_str_mv v. 178, n. 10
identifier_str_mv 1073-449X
v. 178, n. 10
url http://repositorio.ufba.br/ri/handle/ri/13933
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1164/rccm.200801-182OC
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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reponame_str Repositório Institucional da UFBA
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