Association of acanthosis nigricans with race and metabolic disturbances in obese women

Detalhes bibliográficos
Autor(a) principal: Araújo, L. M. B.
Data de Publicação: 2002
Outros Autores: Porto, M. V., M. Netto, E., Ursich, M. J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6705
Resumo: p.59-64
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spelling Araújo, L. M. B.Porto, M. V.M. Netto, E.Ursich, M. J.Araújo, L. M. B.Porto, M. V.M. Netto, E.Ursich, M. J.2012-09-06T15:07:06Z2012-09-06T15:07:06Z2002-011414-431Xhttp://www.repositorio.ufba.br/ri/handle/ri/6705v. 35, n. 1p.59-64Acanthosis nigricans (AN) has been recognized as a marker of insulin resistance and diabetes mellitus. We have compared frequency of race and metabolic disturbances in obese women with several degrees of AN (AN group, N = 190) to a group without AN (non-AN group, N = 61) from a mixed racial population. The groups were similar regarding age and body mass index. All patients (except the diabetic patients) underwent an oral glucose tolerance test (75 g). The racial distribution of this population was 35.1% white, 37.8% mulatto and 27.1% black and the frequency of AN was 62.5, 82.1 and 83.8%, respectively, higher in black versus white (P = 0.003) and mulatto versus white (P = 0.002) women. The frequencies of diabetes mellitus and impaired glucose tolerance were 5.8 and 12.6% in the AN group and 1.6 and 8.2% in the non-AN group, respectively (P>0.05). Fasting glucose, ß cell function determined by the homeostasis model of assessment (HOMA), fasting insulin and insulin area under the curve were similar for the AN and non-AN groups. A higher HOMA insulin resistance was observed in the AN group compared to the non-AN group (P = 0.02) and in the subgroup of highest degree of AN compared to those with other degrees. The mean lipid levels and the frequency of dyslipidemia were similar for the two groups. AN was strongly associated with the black or mulatto rather than the white race, even after taking into account the effect of age, body mass index and HOMA insulin resistance.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-09-06T15:07:06Z No. of bitstreams: 1 Araújo, L.M.B..pdf: 126435 bytes, checksum: 985c730eaac6fcffd9570a4d084a3341 (MD5)Made available in DSpace on 2012-09-06T15:07:06Z (GMT). No. of bitstreams: 1 Araújo, L.M.B..pdf: 126435 bytes, checksum: 985c730eaac6fcffd9570a4d084a3341 (MD5) Previous issue date: 2002-01Ribeirão PretoBrazilian Journal of Medical and Biological Researchhttp://dx.doi.org/10.1590/S0100-879X2002000100008reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAcanthosis nigricansRaceObesityInsulin resistanceHyperinsulinismAssociation of acanthosis nigricans with race and metabolic disturbances in obese womenBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6705/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINALAraújo, L.M.B..pdfAraújo, L.M.B..pdfapplication/pdf126435https://repositorio.ufba.br/bitstream/ri/6705/1/Ara%c3%bajo%2c%20L.M.B..pdf985c730eaac6fcffd9570a4d084a3341MD51TEXTAraújo, L.M.B..pdf.txtAraújo, L.M.B..pdf.txtExtracted texttext/plain21776https://repositorio.ufba.br/bitstream/ri/6705/3/Ara%c3%bajo%2c%20L.M.B..pdf.txt713e48d2f60bf18f97bed6af8150c0b9MD53ri/67052022-07-05 14:03:10.889oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:10Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Association of acanthosis nigricans with race and metabolic disturbances in obese women
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
title Association of acanthosis nigricans with race and metabolic disturbances in obese women
spellingShingle Association of acanthosis nigricans with race and metabolic disturbances in obese women
Araújo, L. M. B.
Acanthosis nigricans
Race
Obesity
Insulin resistance
Hyperinsulinism
title_short Association of acanthosis nigricans with race and metabolic disturbances in obese women
title_full Association of acanthosis nigricans with race and metabolic disturbances in obese women
title_fullStr Association of acanthosis nigricans with race and metabolic disturbances in obese women
title_full_unstemmed Association of acanthosis nigricans with race and metabolic disturbances in obese women
title_sort Association of acanthosis nigricans with race and metabolic disturbances in obese women
author Araújo, L. M. B.
author_facet Araújo, L. M. B.
Porto, M. V.
M. Netto, E.
Ursich, M. J.
author_role author
author2 Porto, M. V.
M. Netto, E.
Ursich, M. J.
author2_role author
author
author
dc.contributor.author.fl_str_mv Araújo, L. M. B.
Porto, M. V.
M. Netto, E.
Ursich, M. J.
Araújo, L. M. B.
Porto, M. V.
M. Netto, E.
Ursich, M. J.
dc.subject.por.fl_str_mv Acanthosis nigricans
Race
Obesity
Insulin resistance
Hyperinsulinism
topic Acanthosis nigricans
Race
Obesity
Insulin resistance
Hyperinsulinism
description p.59-64
publishDate 2002
dc.date.issued.fl_str_mv 2002-01
dc.date.accessioned.fl_str_mv 2012-09-06T15:07:06Z
dc.date.available.fl_str_mv 2012-09-06T15:07:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6705
dc.identifier.issn.none.fl_str_mv 1414-431X
dc.identifier.number.pt_BR.fl_str_mv v. 35, n. 1
identifier_str_mv 1414-431X
v. 35, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/6705
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2002000100008
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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