The TNF-α -308 polymorphism may affect the severity of Crohn's disease

Detalhes bibliográficos
Autor(a) principal: Santana, Genoile
Data de Publicação: 2011
Outros Autores: Bendicho, Maria Teresita Del Niño Jesus Fernandez, Santana, Tamara Celi Almeida, Reis, Lidiane Bianca dos, Lemaire, Denise Carneiro, Lyra, André Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5579
Resumo: p. 1373-1377
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spelling Santana, GenoileBendicho, Maria Teresita Del Niño Jesus FernandezSantana, Tamara Celi AlmeidaReis, Lidiane Bianca dosLemaire, Denise CarneiroLyra, André CastroSantana, GenoileBendicho, Maria Teresita Del Niño Jesus FernandezSantana, Tamara Celi AlmeidaReis, Lidiane Bianca dosLemaire, Denise CarneiroLyra, André Castro2012-03-30T12:35:53Z2012-03-30T12:35:53Z20111807-5932http://www.repositorio.ufba.br/ri/handle/ri/5579v. 66, n. 8.p. 1373-1377OBJECTIVE: The goal of this project was to analyze the association between Crohn's disease, its clinical features, and the tumor necrosis factor alpha (TNF-α) -308 polymorphism. METHODS: This is a case-control and cross-sectional study that enrolled 91 patients with Crohn's disease and 91 controls. Patients with Crohn's disease were characterized according to the Montreal Classification, along with their clinical and surgical treatment history. Analysis of the TNF-α -308 polymorphism was performed using a commercial kit. A stratified analysis was applied using an OR (odds ratio) with a 95% confidence interval. The chi-square and Fisher's exact tests were utilized for analysis of the association between the polymorphism and the clinical features of Crohn's disease. RESULTS: The low producer predicted phenotype was present in 76.9% of Crohn's disease cases and 75.8% of controls (OR 0.94 [0.45-1.97]). The TNF2 allele and the high producer predicted phenotype were more frequent among patients with Crohn's disease penetrating behavior (p = 0.004). The TNF2 allele and the high producer predicted phenotype were also associated with a history of colectomy (p = 0.02), and the TNF2 allele was associated with small bowel resection (p = 0.03). CONCLUSIONS: The TNF-α -308 polymorphism appears to affect the severity of the disease. However, TNF-α -308 polymorphism does not appear to be important for the susceptibility in the development of Crohn's disease.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-03-30T12:35:52Z No. of bitstreams: 1 __www.scielo.br_pdf_clin_v66n8_11.pdf: 90490 bytes, checksum: 7863bb9f147559ba7d2c011cb38924e9 (MD5)Made available in DSpace on 2012-03-30T12:35:53Z (GMT). No. of bitstreams: 1 __www.scielo.br_pdf_clin_v66n8_11.pdf: 90490 bytes, checksum: 7863bb9f147559ba7d2c011cb38924e9 (MD5) Previous issue date: 2011São Paulohttp://dx.doi.org/10.1590/S1807-59322011000800011reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACrohn's diseaseInflammatory bowel diseaseTumor necrosis factor alphaGenetic polymorphismThe TNF-α -308 polymorphism may affect the severity of Crohn's diseaseCLINICSinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL__www.scielo.br_pdf_clin_v66n8_11.pdf__www.scielo.br_pdf_clin_v66n8_11.pdfapplication/pdf90490https://repositorio.ufba.br/bitstream/ri/5579/1/__www.scielo.br_pdf_clin_v66n8_11.pdf7863bb9f147559ba7d2c011cb38924e9MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5579/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT__www.scielo.br_pdf_clin_v66n8_11.pdf.txt__www.scielo.br_pdf_clin_v66n8_11.pdf.txtExtracted texttext/plain29150https://repositorio.ufba.br/bitstream/ri/5579/3/__www.scielo.br_pdf_clin_v66n8_11.pdf.txtc37db4c28bd28c3ae12cd163b59bd84dMD53ri/55792022-07-05 14:02:50.089oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv The TNF-α -308 polymorphism may affect the severity of Crohn's disease
dc.title.alternative.pt_BR.fl_str_mv CLINICS
title The TNF-α -308 polymorphism may affect the severity of Crohn's disease
spellingShingle The TNF-α -308 polymorphism may affect the severity of Crohn's disease
Santana, Genoile
Crohn's disease
Inflammatory bowel disease
Tumor necrosis factor alpha
Genetic polymorphism
title_short The TNF-α -308 polymorphism may affect the severity of Crohn's disease
title_full The TNF-α -308 polymorphism may affect the severity of Crohn's disease
title_fullStr The TNF-α -308 polymorphism may affect the severity of Crohn's disease
title_full_unstemmed The TNF-α -308 polymorphism may affect the severity of Crohn's disease
title_sort The TNF-α -308 polymorphism may affect the severity of Crohn's disease
author Santana, Genoile
author_facet Santana, Genoile
Bendicho, Maria Teresita Del Niño Jesus Fernandez
Santana, Tamara Celi Almeida
Reis, Lidiane Bianca dos
Lemaire, Denise Carneiro
Lyra, André Castro
author_role author
author2 Bendicho, Maria Teresita Del Niño Jesus Fernandez
Santana, Tamara Celi Almeida
Reis, Lidiane Bianca dos
Lemaire, Denise Carneiro
Lyra, André Castro
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Santana, Genoile
Bendicho, Maria Teresita Del Niño Jesus Fernandez
Santana, Tamara Celi Almeida
Reis, Lidiane Bianca dos
Lemaire, Denise Carneiro
Lyra, André Castro
Santana, Genoile
Bendicho, Maria Teresita Del Niño Jesus Fernandez
Santana, Tamara Celi Almeida
Reis, Lidiane Bianca dos
Lemaire, Denise Carneiro
Lyra, André Castro
dc.subject.por.fl_str_mv Crohn's disease
Inflammatory bowel disease
Tumor necrosis factor alpha
Genetic polymorphism
topic Crohn's disease
Inflammatory bowel disease
Tumor necrosis factor alpha
Genetic polymorphism
description p. 1373-1377
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2012-03-30T12:35:53Z
dc.date.available.fl_str_mv 2012-03-30T12:35:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5579
dc.identifier.issn.none.fl_str_mv 1807-5932
dc.identifier.number.pt_BR.fl_str_mv v. 66, n. 8.
identifier_str_mv 1807-5932
v. 66, n. 8.
url http://www.repositorio.ufba.br/ri/handle/ri/5579
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S1807-59322011000800011
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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