Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules

Detalhes bibliográficos
Autor(a) principal: Bacellar, Maria Olívia Amado Ramos
Data de Publicação: 1998
Outros Autores: Russo, C., Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6715
Resumo: p.l575-l581
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spelling Bacellar, Maria Olívia Amado RamosRusso, C.Carvalho Filho, Edgar Marcelino deBacellar, Maria Olívia Amado RamosRusso, C.Carvalho Filho, Edgar Marcelino de2012-09-10T20:14:11Z2012-09-10T20:14:11Z19981414-431Xhttp://www.repositorio.ufba.br/ri/handle/ri/6715v. 31, n. 12p.l575-l581It has been shown that HLA class I molecules play a significant role in the regulation of the proliferation of T cells activated by mitogens and antigens. We evaluated the ability of mAb to a framework determinant of HLA class I molecules to regulate T cell proliferation and interferon gamma (IFN-) production against leishmania, PPD, C. albicans and tetanus toxoid antigens in patients with tegumentary leishmaniasis and healthy subjects. The anti-major histocompatibility complex (MHC) mAb (W6/32) suppressed lymphocyte proliferation by 90% in cultures stimulated with CD3, but the suppression was variable in cultures stimulated with leishmania antigen. This suppression ranged from 30-67% and was observed only in 5 of 11 patients. IFN- production against leishmania antigen was also suppressed by anti-HLA class I mAb. In 3 patients IFN- levels were suppressed by more than 60%, while in the other 2 cultures IFN- levels were 36 and 10% lower than controls. The suppression by HLA class I mAb to the proliferative response in leishmaniasis patients and in healthy controls varied with the antigens and the patients or donors tested. To determine whether the suppression is directed at antigen presenting cells (APCs) or at the responding T cells, experiments with antigen-primed non-adherent cells, separately incubated with W6/32, were performed. Suppression of proliferation was only observed when the W6/32 mAb was added in the presence of T cells. These data provide evidence that a mAb directed at HLA class I framework determinants can suppress proliferation and cytokine secretion in response to several antigens.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-09-10T20:14:11Z No. of bitstreams: 1 Bacellar, O..pdf: 145531 bytes, checksum: eeda637d0350250933ab90ae08efd314 (MD5)Made available in DSpace on 2012-09-10T20:14:11Z (GMT). No. of bitstreams: 1 Bacellar, O..pdf: 145531 bytes, checksum: eeda637d0350250933ab90ae08efd314 (MD5) Previous issue date: 1998-12Ribeirão PretoBrazilian Journal of Medical and Biological Researchhttp://dx.doi.org/10.1590/S0100-879X1998001200010reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHLA class ITegumentary leishmaniasisModulation of T cell response by HLA class IModulation of T cell response by HLA class IInterferon-g and HLA class ISoluble antigen and HLA class IRegulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II moleculesBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALBacellar, O..pdfBacellar, O..pdfapplication/pdf145531https://repositorio.ufba.br/bitstream/ri/6715/1/Bacellar%2c%20O..pdfeeda637d0350250933ab90ae08efd314MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6715/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTBacellar, O..pdf.txtBacellar, O..pdf.txtExtracted texttext/plain28247https://repositorio.ufba.br/bitstream/ri/6715/3/Bacellar%2c%20O..pdf.txt9a8bc8b4e9ff7f2ae06b98c1b96a9a4cMD53ri/67152022-09-23 08:40:49.832oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-09-23T11:40:49Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
title Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules
spellingShingle Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules
Bacellar, Maria Olívia Amado Ramos
HLA class I
Tegumentary leishmaniasis
Modulation of T cell response by HLA class I
Modulation of T cell response by HLA class I
Interferon-g and HLA class I
Soluble antigen and HLA class I
title_short Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules
title_full Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules
title_fullStr Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules
title_full_unstemmed Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules
title_sort Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules
author Bacellar, Maria Olívia Amado Ramos
author_facet Bacellar, Maria Olívia Amado Ramos
Russo, C.
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Russo, C.
Carvalho Filho, Edgar Marcelino de
author2_role author
author
dc.contributor.author.fl_str_mv Bacellar, Maria Olívia Amado Ramos
Russo, C.
Carvalho Filho, Edgar Marcelino de
Bacellar, Maria Olívia Amado Ramos
Russo, C.
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv HLA class I
Tegumentary leishmaniasis
Modulation of T cell response by HLA class I
Modulation of T cell response by HLA class I
Interferon-g and HLA class I
Soluble antigen and HLA class I
topic HLA class I
Tegumentary leishmaniasis
Modulation of T cell response by HLA class I
Modulation of T cell response by HLA class I
Interferon-g and HLA class I
Soluble antigen and HLA class I
description p.l575-l581
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2012-09-10T20:14:11Z
dc.date.available.fl_str_mv 2012-09-10T20:14:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6715
dc.identifier.issn.none.fl_str_mv 1414-431X
dc.identifier.number.pt_BR.fl_str_mv v. 31, n. 12
identifier_str_mv 1414-431X
v. 31, n. 12
url http://www.repositorio.ufba.br/ri/handle/ri/6715
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0100-879X1998001200010
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
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institution UFBA
reponame_str Repositório Institucional da UFBA
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