Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant)

Detalhes bibliográficos
Autor(a) principal: Barnhart, Kurt T.
Data de Publicação: 1997
Outros Autores: Devoto, Luigi, Pommer, Ricardo, Sir Pettermann, Teresa, Robinovic, Jorge, Coutinho, Elsimar Metzker
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8359
Resumo: Texto completo: acesso restrito. p.250–255
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spelling Barnhart, Kurt T.Devoto, LuigiPommer, RicardoSir Pettermann, TeresaRobinovic, JorgeCoutinho, Elsimar MetzkerBarnhart, Kurt T.Devoto, LuigiPommer, RicardoSir Pettermann, TeresaRobinovic, JorgeCoutinho, Elsimar Metzker2013-02-04T16:02:43Z19970015-0282http://www.repositorio.ufba.br/ri/handle/ri/8359v. 67, n. 2Texto completo: acesso restrito. p.250–255Objective: To evaluate a nomegestrol acetate subdermal contraceptive implant's (Uniplant; Thermex, Monaco) effect on the hypothalamus-pituitary-ovarian axis. Design: A prospective clinical trial. Setting: San Borja-Arriarán Clinical Hospital, University of Chile, School of Medicine. Patient(s): Normally cycling healthy women. Intervention(s): Insertion of Uniplant. Main Outcome Measure(s): Luteinizing hormone pulse and endocrine profiles were assessed before, 48 hours after insertion, and after prolonged use of the implant. Result(s): Anovulation was noted in 100% of users in the first month. Seventy percent of subjects demonstrated follicular development with the absence of ovulation and an endocrine profile similar to the follicular phase: (LH pulse/8 hours 6.85 ± 0.67, LH amplitude 3.54 ± 0.65 mlU/mL (conversion factor to SI unit, 1.00), and E2 193 ± 29.4 pg/mL (conversion factor to SI unit, 3.67), whereas 30% demonstrated no follicular activity with an endocrine profile similar to the luteal phase: (LH pulse/8 hours; 3.66 ± 0.66, LH amplitude 5.76 ± 1.73 mlU/mL, and E2 67.5 ± 4 pg/mL. Clinical characteristics, serum gonadotropin concentration, and LH pulse characteristics failed to predict which subjects would initiate or remain devoid of follicular activity. Conclusion(s): Uniplant results in anovulation via two mechanisms: hypothalamic suppression in subjects who lack follicular development, and likely suppression of the pituitary LH surge in subjects who initiate follicular activity.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-02-04T14:54:08Z No. of bitstreams: 1 Barnhart.pdf: 753131 bytes, checksum: d0d7ac07304580dbd1a9fe6571b7f44f (MD5)Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-02-04T16:02:43Z (GMT) No. of bitstreams: 1 Barnhart.pdf: 753131 bytes, checksum: d0d7ac07304580dbd1a9fe6571b7f44f (MD5)Made available in DSpace on 2013-02-04T16:02:43Z (GMT). No. of bitstreams: 1 Barnhart.pdf: 753131 bytes, checksum: d0d7ac07304580dbd1a9fe6571b7f44f (MD5) Previous issue date: 1997http://dx.doi.org/10.1016/S0015-0282(97)81906-1reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBANomegestrol acetate subdermal implantsLH pulse hypothalamic pituitary fimctionNeuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant)Fertility and Sterilityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALBarnhart.pdfBarnhart.pdfapplication/pdf753131https://repositorio.ufba.br/bitstream/ri/8359/1/Barnhart.pdfd0d7ac07304580dbd1a9fe6571b7f44fMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8359/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTBarnhart.pdf.txtBarnhart.pdf.txtExtracted texttext/plain29485https://repositorio.ufba.br/bitstream/ri/8359/3/Barnhart.pdf.txte32683b328d31f7ba610bbe8391faf34MD53ri/83592022-07-05 14:03:13.04oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant)
dc.title.alternative.pt_BR.fl_str_mv Fertility and Sterility
title Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant)
spellingShingle Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant)
Barnhart, Kurt T.
Nomegestrol acetate subdermal implants
LH pulse hypothalamic pituitary fimction
title_short Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant)
title_full Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant)
title_fullStr Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant)
title_full_unstemmed Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant)
title_sort Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant)
author Barnhart, Kurt T.
author_facet Barnhart, Kurt T.
Devoto, Luigi
Pommer, Ricardo
Sir Pettermann, Teresa
Robinovic, Jorge
Coutinho, Elsimar Metzker
author_role author
author2 Devoto, Luigi
Pommer, Ricardo
Sir Pettermann, Teresa
Robinovic, Jorge
Coutinho, Elsimar Metzker
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Barnhart, Kurt T.
Devoto, Luigi
Pommer, Ricardo
Sir Pettermann, Teresa
Robinovic, Jorge
Coutinho, Elsimar Metzker
Barnhart, Kurt T.
Devoto, Luigi
Pommer, Ricardo
Sir Pettermann, Teresa
Robinovic, Jorge
Coutinho, Elsimar Metzker
dc.subject.por.fl_str_mv Nomegestrol acetate subdermal implants
LH pulse hypothalamic pituitary fimction
topic Nomegestrol acetate subdermal implants
LH pulse hypothalamic pituitary fimction
description Texto completo: acesso restrito. p.250–255
publishDate 1997
dc.date.issued.fl_str_mv 1997
dc.date.accessioned.fl_str_mv 2013-02-04T16:02:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8359
dc.identifier.issn.none.fl_str_mv 0015-0282
dc.identifier.number.pt_BR.fl_str_mv v. 67, n. 2
identifier_str_mv 0015-0282
v. 67, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/8359
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/S0015-0282(97)81906-1
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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collection Repositório Institucional da UFBA
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