Effect of chronic oral administration of a low dose of captopril on sodium appetite of hypothyroid rats. Influence of aldosterone treatment

Detalhes bibliográficos
Autor(a) principal: Ventura, R. R.
Data de Publicação: 2001
Outros Autores: Olivares, E. L., Passos Junior, D. B., Ramalho, Maria José Pedreira, Rodrigues, José Antunes, Reis, L. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7051
Resumo: p. 407-411
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spelling Ventura, R. R.Olivares, E. L.Passos Junior, D. B.Ramalho, Maria José PedreiraRodrigues, José AntunesReis, L. C.Ventura, R. R.Olivares, E. L.Passos Junior, D. B.Ramalho, Maria José PedreiraRodrigues, José AntunesReis, L. C.2012-10-24T19:15:25Z2012-10-24T19:15:25Z20011414-431Xhttp://www.repositorio.ufba.br/ri/handle/ri/7051v. 34, n. 3p. 407-411Rats rendered hypothyroid by treatment with methimazole develop an exaggerated sodium appetite. We investigated here the capacity of hypothyroid rats (N = 12 for each group) to respond to a low dose of captopril added to the ration, a paradigm which induces an increase in angiotensin II synthesis in cerebral areas that regulate sodium appetite by increasing the availability of circulating angiotensin I. In addition, we determined the influence of aldosterone in hypothyroid rats during the expression of spontaneous sodium appetite and after captopril treatment. Captopril significantly increased (P<0.05) the daily intake of 1.8% NaCl (in ml/100 g body weight) in hypothyroid rats after 36 days of methimazole administration (day 36: 9.2 ± 0.7 vs day 32: 2.8 ± 0.6 ml, on the 4th day after captopril treatment). After the discontinuation of captopril treatment, daily 1.8% NaCl intake reached values ranging from 10.0 ± 0.9 to 13.9 ± 1.0 ml, 48 to 60 days after treatment with methimazole. Aldosterone treatment significantly reduced (P<0.05) saline intake before (7.3 ± 1.6 vs day 0, 14.4 ± 1.3 ml) and after captopril treatment. Our results demonstrate that, although hypothyroid rats develop a deficiency in the production of all components of the renin-angiotensin-aldosterone system, their capacity to synthesize angiotensin II at the cerebral level is preserved. The partial reversal of daily 1.8% NaCl intake during aldosterone treatment suggests that sodium retention reduces both spontaneous and captopril-induced salt appetite.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-10-24T19:15:25Z No. of bitstreams: 1 Ventura, R.R..pdf: 161629 bytes, checksum: 1cba628d580609dd05b82229b895b55b (MD5)Made available in DSpace on 2012-10-24T19:15:25Z (GMT). No. of bitstreams: 1 Ventura, R.R..pdf: 161629 bytes, checksum: 1cba628d580609dd05b82229b895b55b (MD5) Previous issue date: 2001Ribeirão PretoBrazilian Journal of Medical and Biological Researchhttp://dx.doi.org/10.1590/S0100-879X2001000300016reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAsodium appetitehypothyroidismcaptoprilaldosteroneratsEffect of chronic oral administration of a low dose of captopril on sodium appetite of hypothyroid rats. 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dc.title.pt_BR.fl_str_mv Effect of chronic oral administration of a low dose of captopril on sodium appetite of hypothyroid rats. Influence of aldosterone treatment
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
title Effect of chronic oral administration of a low dose of captopril on sodium appetite of hypothyroid rats. Influence of aldosterone treatment
spellingShingle Effect of chronic oral administration of a low dose of captopril on sodium appetite of hypothyroid rats. Influence of aldosterone treatment
Ventura, R. R.
sodium appetite
hypothyroidism
captopril
aldosterone
rats
title_short Effect of chronic oral administration of a low dose of captopril on sodium appetite of hypothyroid rats. Influence of aldosterone treatment
title_full Effect of chronic oral administration of a low dose of captopril on sodium appetite of hypothyroid rats. Influence of aldosterone treatment
title_fullStr Effect of chronic oral administration of a low dose of captopril on sodium appetite of hypothyroid rats. Influence of aldosterone treatment
title_full_unstemmed Effect of chronic oral administration of a low dose of captopril on sodium appetite of hypothyroid rats. Influence of aldosterone treatment
title_sort Effect of chronic oral administration of a low dose of captopril on sodium appetite of hypothyroid rats. Influence of aldosterone treatment
author Ventura, R. R.
author_facet Ventura, R. R.
Olivares, E. L.
Passos Junior, D. B.
Ramalho, Maria José Pedreira
Rodrigues, José Antunes
Reis, L. C.
author_role author
author2 Olivares, E. L.
Passos Junior, D. B.
Ramalho, Maria José Pedreira
Rodrigues, José Antunes
Reis, L. C.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ventura, R. R.
Olivares, E. L.
Passos Junior, D. B.
Ramalho, Maria José Pedreira
Rodrigues, José Antunes
Reis, L. C.
Ventura, R. R.
Olivares, E. L.
Passos Junior, D. B.
Ramalho, Maria José Pedreira
Rodrigues, José Antunes
Reis, L. C.
dc.subject.por.fl_str_mv sodium appetite
hypothyroidism
captopril
aldosterone
rats
topic sodium appetite
hypothyroidism
captopril
aldosterone
rats
description p. 407-411
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2012-10-24T19:15:25Z
dc.date.available.fl_str_mv 2012-10-24T19:15:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7051
dc.identifier.issn.none.fl_str_mv 1414-431X
dc.identifier.number.pt_BR.fl_str_mv v. 34, n. 3
identifier_str_mv 1414-431X
v. 34, n. 3
url http://www.repositorio.ufba.br/ri/handle/ri/7051
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2001000300016
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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