Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study

Detalhes bibliográficos
Autor(a) principal: Gurgel, Clarissa Araújo Silva
Data de Publicação: 2008
Outros Autores: Ramos, Eduardo Antônio Gonçalves, Azevedo, Roberto Almeida de, Sarmento, Viviane Almeida, Carvalho, Ana Maria da Silva, Santos, Jean Nunes dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6142
Resumo: Acesso restrito: Texto completo. p. 311-316.
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spelling Gurgel, Clarissa Araújo SilvaRamos, Eduardo Antônio GonçalvesAzevedo, Roberto Almeida deSarmento, Viviane AlmeidaCarvalho, Ana Maria da SilvaSantos, Jean Nunes dosGurgel, Clarissa Araújo SilvaRamos, Eduardo Antônio GonçalvesAzevedo, Roberto Almeida deSarmento, Viviane AlmeidaCarvalho, Ana Maria da SilvaSantos, Jean Nunes dos2012-06-14T13:31:22Z20081567-2379http://www.repositorio.ufba.br/ri/handle/ri/6142v. 39, n. 3Acesso restrito: Texto completo. p. 311-316.Aim To investigate the immunohistochemical expression of Ki-67, p53 and p63 in Keratocyst Odontogenic Tumours (KOTs) in order to contribute to the biological profile of this tumor. Methods Immunohistochemical technique was performed using the EnVisionTM System in 37 cases of KOTs. Results Ki-67- and p53-immunostained cells were mainly located in the suprabasal layers. p63-positive cells were found throughout the lining cystic epithelium. No difference in the immunostaining for these proteins was observed between primary and recurrent KOTs (Ki-67: P = 0.5591; p53: P = 0.9847; p63:P = 0.9127), or between KOTs associated with Nevoid Basal Cell Carcinoma Syndrome (NBCCS) and sporadic KOTs (Ki-67: P = 0.7013; p53: P = 0.3197; p63: P = 0.2427). Conclusions It is possible that biological behavior of KOTs may be related to suprabasal proliferative compartment in the cystic epithelium as observed by high levels of Ki-67, p53 and p63. In addition, p63 immunostaining may represent immaturity of keratinocytes in KOTs, and suggests that this protein may participate in the regulation of epithelial cell differentiation. Taken together, these data may favor tumorigenesis on KOTs.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-06-14T13:31:22Z No. of bitstreams: 1 __www.springerlink.com_c...011m0v555u8p7002_fulltext.pdf: 207261 bytes, checksum: 0dce8de9ecb490d15496f1f3c9e6287f (MD5)Made available in DSpace on 2012-06-14T13:31:22Z (GMT). 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dc.title.pt_BR.fl_str_mv Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study
dc.title.alternative.pt_BR.fl_str_mv Journal of Molecular Histology
title Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study
spellingShingle Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study
Gurgel, Clarissa Araújo Silva
Odontogenic cysts
Keratocyst odontogenic tumour
Cell proliferation
Ki-67
title_short Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study
title_full Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study
title_fullStr Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study
title_full_unstemmed Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study
title_sort Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study
author Gurgel, Clarissa Araújo Silva
author_facet Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Azevedo, Roberto Almeida de
Sarmento, Viviane Almeida
Carvalho, Ana Maria da Silva
Santos, Jean Nunes dos
author_role author
author2 Ramos, Eduardo Antônio Gonçalves
Azevedo, Roberto Almeida de
Sarmento, Viviane Almeida
Carvalho, Ana Maria da Silva
Santos, Jean Nunes dos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Azevedo, Roberto Almeida de
Sarmento, Viviane Almeida
Carvalho, Ana Maria da Silva
Santos, Jean Nunes dos
Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Azevedo, Roberto Almeida de
Sarmento, Viviane Almeida
Carvalho, Ana Maria da Silva
Santos, Jean Nunes dos
dc.subject.por.fl_str_mv Odontogenic cysts
Keratocyst odontogenic tumour
Cell proliferation
Ki-67
topic Odontogenic cysts
Keratocyst odontogenic tumour
Cell proliferation
Ki-67
description Acesso restrito: Texto completo. p. 311-316.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-06-14T13:31:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6142
dc.identifier.issn.none.fl_str_mv 1567-2379
dc.identifier.number.pt_BR.fl_str_mv v. 39, n. 3
identifier_str_mv 1567-2379
v. 39, n. 3
url http://www.repositorio.ufba.br/ri/handle/ri/6142
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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