Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil

Detalhes bibliográficos
Autor(a) principal: Barreto, Mauricio Lima
Data de Publicação: 1994
Outros Autores: Farenzena, G. G., Fiaccone, R. L., Santos, L. M. P., Assis, Ana Marlucia de Oliveira, Araújo, M. P. N., Santos, P. A. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12969
Resumo: Texto completo. Acesso restrito. p. 228–231
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spelling Barreto, Mauricio LimaFarenzena, G. G.Fiaccone, R. L.Santos, L. M. P.Assis, Ana Marlucia de OliveiraAraújo, M. P. N.Santos, P. A. B.Barreto, Mauricio LimaFarenzena, G. G.Fiaccone, R. L.Santos, L. M. P.Assis, Ana Marlucia de OliveiraAraújo, M. P. N.Santos, P. A. B.2013-09-17T17:43:36Z2013-09-17T17:43:36Z19940140-6736http://www.repositorio.ufba.br/ri/handle/ri/12969v. 344, n. 8917Texto completo. Acesso restrito. p. 228–231A beneficial effect of periodic vitamin A supplementation on childhood mortality has been demonstrated, but the effect on morbidity is less clear. We investigated the effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections (ALRI) in children from northeastern Brazil in a randomised, double-blind, placebo-controlled community trial. 1240 children aged 6-48 months were assigned vitamin A or placebo every 4 months for 1 year. They were followed up at home three times a week, and data about the occurrence and severity of diarrhoea and ALRI were collected. Any child with cough and respiratory rate above 40 breaths per min was visited by a paediatrician. The overall incidence of diarrhoea episodes was significantly lower in the vitamin-A-supplemented group than in the placebo group (18·42 vs 19·58 × 10-3 child-days; rate ratio 0·94 [95% Cl 0·90-0·9 8]). The benefit of supplementation was greater as regards severe episodes of diarrhoea; the incidence was 20% lower in the vitamin A group than in the placebo group (rate ratio 0·80 [0·65-0·98]). With the standard definition of diarrhoea (≥3 liquid or semi-liquid stools in 24 h) the effect of vitamin A on mean daily prevalence did not reach significance, but as the definition of diarrhoea was made more stringent (increasing number of stools per day), a significant benefit became apparent, reaching for diarrhoea with 6 or more liquid or semi-liquid stools in 24 h a 23% lower prevalence. We found no effect of vitamin A supplementation on the incidence of ALRI. The reduction in severity of diarrhoea may be the most important factor in the lowering of mortality by vitamin A supplementation.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-09-17T17:43:36Z No. of bitstreams: 1 11111111.pdf: 596229 bytes, checksum: f2d85e7c7f938d2506d1a3b89e4a2799 (MD5)Made available in DSpace on 2013-09-17T17:43:36Z (GMT). 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dc.title.pt_BR.fl_str_mv Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil
dc.title.alternative.pt_BR.fl_str_mv Lancet
title Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil
spellingShingle Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil
Barreto, Mauricio Lima
title_short Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil
title_full Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil
title_fullStr Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil
title_full_unstemmed Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil
title_sort Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil
author Barreto, Mauricio Lima
author_facet Barreto, Mauricio Lima
Farenzena, G. G.
Fiaccone, R. L.
Santos, L. M. P.
Assis, Ana Marlucia de Oliveira
Araújo, M. P. N.
Santos, P. A. B.
author_role author
author2 Farenzena, G. G.
Fiaccone, R. L.
Santos, L. M. P.
Assis, Ana Marlucia de Oliveira
Araújo, M. P. N.
Santos, P. A. B.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barreto, Mauricio Lima
Farenzena, G. G.
Fiaccone, R. L.
Santos, L. M. P.
Assis, Ana Marlucia de Oliveira
Araújo, M. P. N.
Santos, P. A. B.
Barreto, Mauricio Lima
Farenzena, G. G.
Fiaccone, R. L.
Santos, L. M. P.
Assis, Ana Marlucia de Oliveira
Araújo, M. P. N.
Santos, P. A. B.
description Texto completo. Acesso restrito. p. 228–231
publishDate 1994
dc.date.issued.fl_str_mv 1994
dc.date.accessioned.fl_str_mv 2013-09-17T17:43:36Z
dc.date.available.fl_str_mv 2013-09-17T17:43:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12969
dc.identifier.issn.none.fl_str_mv 0140-6736
dc.identifier.number.pt_BR.fl_str_mv v. 344, n. 8917
identifier_str_mv 0140-6736
v. 344, n. 8917
url http://www.repositorio.ufba.br/ri/handle/ri/12969
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lancet
publisher.none.fl_str_mv Lancet
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