Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/15588 |
Resumo: | Texto completo: acesso restrito. p. 126–134 |
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Costa, Ryan dos SantosCarneiro, Tamires Cana BrasilLima, Ana Tereza CerqueiraQueiroz, Norma VilanyAlcântara-Neves, Neuza MariaCarvalho, Lain Carlos Pontes deVelozo, Eudes da SilvaOliveira, Eduardo de JesusFigueiredo, Camila AlexandrinaCosta, Ryan dos SantosCarneiro, Tamires Cana BrasilLima, Ana Tereza CerqueiraQueiroz, Norma VilanyAlcântara-Neves, Neuza MariaCarvalho, Lain Carlos Pontes deVelozo, Eudes da SilvaOliveira, Eduardo de JesusFigueiredo, Camila Alexandrina2014-08-12T19:56:41Z20121567-5769http://repositorio.ufba.br/ri/handle/ri/15588v. 18, n. 1Texto completo: acesso restrito. p. 126–134Allergic asthma has emerged as an important public health problem of urban populations in developed countries. Very often herbal medicine is used to treat this widespread disease, due to the lack of efficacy and the important side effects related to the classical drugs in use. Along this line, Ocimum gratissimum (Og) is a plant widely used in Brazilian folk medicine to treat inflammatory disorders, such as asthma. In the present study we evaluated the immunomodulatory effects of Og and rosmarinic acid (RA, a polyphenolic compound) in a murine model of respiratory allergy induced by the Blomia tropicalis (Bt) mite. The respiratory allergy was induced in A/J mice by administration of Bt extract and the treatment was done using 25, 50 or 100 mg/kg of an Og methanolic extract or using 2, 20 or 200 mg/kg of RA. We then evaluated the changes induced by these drugs on immunological parameters related to the allergic process, which are up-regulated in this allergic model. The treatment of animals with 100 mg/Kg Og and 200 mg/Kg RA led to a significant reduction in the numbers of leukocytes/eosinophils in bronchoalveolar lavage (BAL); eosinophil peroxidase activity in BAL; presence of mucus in respiratory tract, histopathological changes in the lung, and IL-4 in BAL. These results suggest that the methanolic extract of Og and the polyphenol RA have therapeutic potential in this murine model of respiratory allergy to a clinically relevant human sensitizer allergen.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-12T15:19:01Z No. of bitstreams: 1 Ryan Santos Costa.pdf: 2216829 bytes, checksum: 513639b3e092aea34adaa12835404c4a (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-08-12T19:56:41Z (GMT) No. of bitstreams: 1 Ryan Santos Costa.pdf: 2216829 bytes, checksum: 513639b3e092aea34adaa12835404c4a (MD5)Made available in DSpace on 2014-08-12T19:56:41Z (GMT). No. of bitstreams: 1 Ryan Santos Costa.pdf: 2216829 bytes, checksum: 513639b3e092aea34adaa12835404c4a (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1016/j.intimp.2012.03.012reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAsthmaBlomia tropicalisInflammationOcimum gratissimumPolyphenolsRosmarinic acidOcimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalisInternational Immunopharmacologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALRyan Santos Costa.pdfRyan Santos Costa.pdfapplication/pdf2216829https://repositorio.ufba.br/bitstream/ri/15588/1/Ryan%20Santos%20Costa.pdf513639b3e092aea34adaa12835404c4aMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15588/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTRyan Santos Costa.pdf.txtRyan Santos Costa.pdf.txtExtracted texttext/plain43507https://repositorio.ufba.br/bitstream/ri/15588/3/Ryan%20Santos%20Costa.pdf.txt6b0282f5a6153b7b431d16442699922eMD53ri/155882022-07-05 14:03:31.964oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:31Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis |
| dc.title.alternative.pt_BR.fl_str_mv |
International Immunopharmacology |
| title |
Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis |
| spellingShingle |
Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis Costa, Ryan dos Santos Asthma Blomia tropicalis Inflammation Ocimum gratissimum Polyphenols Rosmarinic acid |
| title_short |
Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis |
| title_full |
Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis |
| title_fullStr |
Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis |
| title_full_unstemmed |
Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis |
| title_sort |
Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis |
| author |
Costa, Ryan dos Santos |
| author_facet |
Costa, Ryan dos Santos Carneiro, Tamires Cana Brasil Lima, Ana Tereza Cerqueira Queiroz, Norma Vilany Alcântara-Neves, Neuza Maria Carvalho, Lain Carlos Pontes de Velozo, Eudes da Silva Oliveira, Eduardo de Jesus Figueiredo, Camila Alexandrina |
| author_role |
author |
| author2 |
Carneiro, Tamires Cana Brasil Lima, Ana Tereza Cerqueira Queiroz, Norma Vilany Alcântara-Neves, Neuza Maria Carvalho, Lain Carlos Pontes de Velozo, Eudes da Silva Oliveira, Eduardo de Jesus Figueiredo, Camila Alexandrina |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Costa, Ryan dos Santos Carneiro, Tamires Cana Brasil Lima, Ana Tereza Cerqueira Queiroz, Norma Vilany Alcântara-Neves, Neuza Maria Carvalho, Lain Carlos Pontes de Velozo, Eudes da Silva Oliveira, Eduardo de Jesus Figueiredo, Camila Alexandrina Costa, Ryan dos Santos Carneiro, Tamires Cana Brasil Lima, Ana Tereza Cerqueira Queiroz, Norma Vilany Alcântara-Neves, Neuza Maria Carvalho, Lain Carlos Pontes de Velozo, Eudes da Silva Oliveira, Eduardo de Jesus Figueiredo, Camila Alexandrina |
| dc.subject.por.fl_str_mv |
Asthma Blomia tropicalis Inflammation Ocimum gratissimum Polyphenols Rosmarinic acid |
| topic |
Asthma Blomia tropicalis Inflammation Ocimum gratissimum Polyphenols Rosmarinic acid |
| description |
Texto completo: acesso restrito. p. 126–134 |
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2012 |
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2012 |
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2014-08-12T19:56:41Z |
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1567-5769 |
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v. 18, n. 1 |
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1567-5769 v. 18, n. 1 |
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