Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome

Detalhes bibliográficos
Autor(a) principal: Lyra, Priscila Pinheiro Ribeiro
Data de Publicação: 2011
Outros Autores: Diniz, E. M. A., Abe Sandes, Kiyoko, Angelo, Ana Luiza Dias, Machado, Taisa Manuela Bonfim, Cardeal, Mauricio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5581
Resumo: p. 66-72
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spelling Lyra, Priscila Pinheiro RibeiroDiniz, E. M. A.Abe Sandes, KiyokoAngelo, Ana Luiza DiasMachado, Taisa Manuela BonfimCardeal, MauricioLyra, Priscila Pinheiro RibeiroDiniz, E. M. A.Abe Sandes, KiyokoAngelo, Ana Luiza DiasMachado, Taisa Manuela BonfimCardeal, Mauricio2012-03-30T13:33:35Z2012-03-30T13:33:35Z20110100-879Xhttp://www.repositorio.ufba.br/ri/handle/ri/5581v. 44, n. 1.p. 66-72The etiology of respiratory distress syndrome (RDS) is multifactorial and multigenic. Studies have suggested that polymorphisms and mutations in the surfactant protein B (SP-B) gene are associated with the pathogenesis of RDS. The objectives of this study were to determine and compare the frequencies of SP-B gene polymorphisms in preterm babies with and without RDS. We studied 151 neonates: 79 preterm babies without RDS and 72 preterm newborns with RDS. The following four SP-B gene polymorphisms were analyzed: A/C at -18, C/T at 1580, A/G at 9306, and G/C at nucleotide 8714. The polymorphisms were detected by PCR amplification of genomic DNA and genotyping. The genotypes were determined using PCR-based converted restriction fragment length polymorphisms. The control group consisted of 42 (53%) girls and 37 (47%) boys. Weight ranged from 1170 to 3260 g and mean gestational age (GA) was 33.9 weeks (range: 29 to 35 weeks and 6 days). The RDS group consisted of 31 (43%) girls and 41 (57%) boys. Weight ranged from 614 to 2410 g and mean GA was 32 weeks (range: 26 to 35 weeks). The logistic regression model showed that GA was the variable that most contributed to the occurrence of RDS. The AG genotype of the A/G polymorphism at position 9306 of the SP-B gene was a protective factor in this population (OR = 0.1681; 95%CI = 0.0426-0.6629). We did not detect differences in the frequencies of the other polymorphisms between the two groups of newborns.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-03-30T13:33:35Z No. of bitstreams: 1 __www.scielo.br_pdf_bjmbr_v44n1_480.pdf: 289328 bytes, checksum: 3c8fd61fa7bc726b3963231f46c11345 (MD5)Made available in DSpace on 2012-03-30T13:33:35Z (GMT). No. of bitstreams: 1 __www.scielo.br_pdf_bjmbr_v44n1_480.pdf: 289328 bytes, checksum: 3c8fd61fa7bc726b3963231f46c11345 (MD5) Previous issue date: 2011Ribeirão Pretohttp://dx.doi.org/10.1590/S0100-879X2010007500147reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBANewborn respiratory distress syndromeGenetic polymorphismSurfactant protein BSurfactant protein B gene polymorphism in preterm babies with respiratory distress syndromeBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL__www.scielo.br_pdf_bjmbr_v44n1_480.pdf__www.scielo.br_pdf_bjmbr_v44n1_480.pdfapplication/pdf289328https://repositorio.ufba.br/bitstream/ri/5581/1/__www.scielo.br_pdf_bjmbr_v44n1_480.pdf3c8fd61fa7bc726b3963231f46c11345MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5581/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT__www.scielo.br_pdf_bjmbr_v44n1_480.pdf.txt__www.scielo.br_pdf_bjmbr_v44n1_480.pdf.txtExtracted texttext/plain29957https://repositorio.ufba.br/bitstream/ri/5581/3/__www.scielo.br_pdf_bjmbr_v44n1_480.pdf.txtad2d3474f1268845d8772f60d7df3e19MD53ri/55812022-07-05 14:03:23.14oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:23Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
title Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome
spellingShingle Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome
Lyra, Priscila Pinheiro Ribeiro
Newborn respiratory distress syndrome
Genetic polymorphism
Surfactant protein B
title_short Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome
title_full Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome
title_fullStr Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome
title_full_unstemmed Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome
title_sort Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome
author Lyra, Priscila Pinheiro Ribeiro
author_facet Lyra, Priscila Pinheiro Ribeiro
Diniz, E. M. A.
Abe Sandes, Kiyoko
Angelo, Ana Luiza Dias
Machado, Taisa Manuela Bonfim
Cardeal, Mauricio
author_role author
author2 Diniz, E. M. A.
Abe Sandes, Kiyoko
Angelo, Ana Luiza Dias
Machado, Taisa Manuela Bonfim
Cardeal, Mauricio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lyra, Priscila Pinheiro Ribeiro
Diniz, E. M. A.
Abe Sandes, Kiyoko
Angelo, Ana Luiza Dias
Machado, Taisa Manuela Bonfim
Cardeal, Mauricio
Lyra, Priscila Pinheiro Ribeiro
Diniz, E. M. A.
Abe Sandes, Kiyoko
Angelo, Ana Luiza Dias
Machado, Taisa Manuela Bonfim
Cardeal, Mauricio
dc.subject.por.fl_str_mv Newborn respiratory distress syndrome
Genetic polymorphism
Surfactant protein B
topic Newborn respiratory distress syndrome
Genetic polymorphism
Surfactant protein B
description p. 66-72
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2012-03-30T13:33:35Z
dc.date.available.fl_str_mv 2012-03-30T13:33:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5581
dc.identifier.issn.none.fl_str_mv 0100-879X
dc.identifier.number.pt_BR.fl_str_mv v. 44, n. 1.
identifier_str_mv 0100-879X
v. 44, n. 1.
url http://www.repositorio.ufba.br/ri/handle/ri/5581
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2010007500147
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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