Transcranial DC Stimulation in Fibromyalgia: Optimized Cortical Target Supported by High-Resolution Computational Models

Detalhes bibliográficos
Autor(a) principal: Mendonca, Mariana E.
Data de Publicação: 2011
Outros Autores: Santana, Marcus B., Baptista, Abrahão Fontes, Datta, Abhishek, Bikson, Marom, Fregni, Felipe, Araujo, Cintia P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5424
Resumo: Acesso restrito: Texto completo. p. 610-617.
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spelling Mendonca, Mariana E.Santana, Marcus B.Baptista, Abrahão FontesDatta, AbhishekBikson, MaromFregni, FelipeAraujo, Cintia P.Mendonca, Mariana E.Santana, Marcus B.Baptista, Abrahão FontesDatta, AbhishekBikson, MaromFregni, FelipeAraujo, Cintia P.2012-02-23T17:45:38Z20111526-5900http://www.repositorio.ufba.br/ri/handle/ri/5424v. 12, n. 5.Acesso restrito: Texto completo. p. 610-617.In this study we aimed to determine current distribution and short-term analgesic effects of transcranial direct current stimulation (tDCS) in fibromyalgia using different electrode montages.For each electrode montage, clinical effects were correlated with predictions of induced cortical current flow using magnetic resonance imaging–derived finite element method head model. Thirty patients were randomized into 5 groups (Cathodal-M1 [primary motor cortex], Cathodal-SO [supraorbital area], Anodal-M1, Anodal-SO, and Sham) to receive tDCS application (2 mA, 20 minutes) using an extracephalic montage. Pain was measured using a visual numerical scale (VNS), pressure pain threshold (PPT), and a body diagram (BD) evaluating pain area. There was significant pain reduction in cathodal-SO and anodal-SO groups indexed by VNS. For PPT there was a trend for a similar effect in anodal-SO group. Computer simulation indicated that the M1-extracephalic montage produced dominantly temporo-parietal current flow, consistent with lack of clinical effects with this montage.Conversely, the SO-extracephalic montage produced current flow across anterior prefrontal structures, thus supporting the observed analgesic effects. Our clinical and modeling findings suggest that electrode montage, considering both electrodes, is critical for the clinical effects of M1-tDCS as electric current needs to be induced in areas associated with the pain matrix. These results should be taken into consideration for the design of pain tDCS studies. Perspective: Results in this article support that electrode montage is a critical factor to consider for the clinical application of tDCS for pain control, as there is an important correlation between the location of induced electrical current and tDCS-induced analgesic effects.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-02-23T17:45:37Z No. of bitstreams: 1 __pdn.sciencedirect.com_....0-S1526590011000289-main.pdf: 477995 bytes, checksum: 1fc49f13a5b536ec3d65f3b8a9ad21bc (MD5)Made available in DSpace on 2012-02-23T17:45:38Z (GMT). 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dc.title.pt_BR.fl_str_mv Transcranial DC Stimulation in Fibromyalgia: Optimized Cortical Target Supported by High-Resolution Computational Models
dc.title.alternative.pt_BR.fl_str_mv JOURNAL OF PAIN
title Transcranial DC Stimulation in Fibromyalgia: Optimized Cortical Target Supported by High-Resolution Computational Models
spellingShingle Transcranial DC Stimulation in Fibromyalgia: Optimized Cortical Target Supported by High-Resolution Computational Models
Mendonca, Mariana E.
Chronic pain
fibromyalgia
transcranial direct current stimulation
finite element modeling
MRI human head model
electrode montage
title_short Transcranial DC Stimulation in Fibromyalgia: Optimized Cortical Target Supported by High-Resolution Computational Models
title_full Transcranial DC Stimulation in Fibromyalgia: Optimized Cortical Target Supported by High-Resolution Computational Models
title_fullStr Transcranial DC Stimulation in Fibromyalgia: Optimized Cortical Target Supported by High-Resolution Computational Models
title_full_unstemmed Transcranial DC Stimulation in Fibromyalgia: Optimized Cortical Target Supported by High-Resolution Computational Models
title_sort Transcranial DC Stimulation in Fibromyalgia: Optimized Cortical Target Supported by High-Resolution Computational Models
author Mendonca, Mariana E.
author_facet Mendonca, Mariana E.
Santana, Marcus B.
Baptista, Abrahão Fontes
Datta, Abhishek
Bikson, Marom
Fregni, Felipe
Araujo, Cintia P.
author_role author
author2 Santana, Marcus B.
Baptista, Abrahão Fontes
Datta, Abhishek
Bikson, Marom
Fregni, Felipe
Araujo, Cintia P.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mendonca, Mariana E.
Santana, Marcus B.
Baptista, Abrahão Fontes
Datta, Abhishek
Bikson, Marom
Fregni, Felipe
Araujo, Cintia P.
Mendonca, Mariana E.
Santana, Marcus B.
Baptista, Abrahão Fontes
Datta, Abhishek
Bikson, Marom
Fregni, Felipe
Araujo, Cintia P.
dc.subject.por.fl_str_mv Chronic pain
fibromyalgia
transcranial direct current stimulation
finite element modeling
MRI human head model
electrode montage
topic Chronic pain
fibromyalgia
transcranial direct current stimulation
finite element modeling
MRI human head model
electrode montage
description Acesso restrito: Texto completo. p. 610-617.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2012-02-23T17:45:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5424
dc.identifier.issn.none.fl_str_mv 1526-5900
dc.identifier.number.pt_BR.fl_str_mv v. 12, n. 5.
identifier_str_mv 1526-5900
v. 12, n. 5.
url http://www.repositorio.ufba.br/ri/handle/ri/5424
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv DOI: 10.1016/j.jpain.2010.12.015
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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instacron:UFBA
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