Effectiveness of BCG vaccination among leprosy contacts: a cohort study

Detalhes bibliográficos
Autor(a) principal: Düppre, N. C.
Data de Publicação: 2008
Outros Autores: Camacho, Luiz Antonio Bastos, Cunha, Sérgio Souza da, Struchiner, Claudio José, Sales, A. M., Nery, J. A. C., Sarno, E. N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6122
Resumo: Acesso restrito: Texto completo. p. 631-638
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spelling Düppre, N. C.Camacho, Luiz Antonio BastosCunha, Sérgio Souza daStruchiner, Claudio JoséSales, A. M.Nery, J. A. C.Sarno, E. N.Düppre, N. C.Camacho, Luiz Antonio BastosCunha, Sérgio Souza daStruchiner, Claudio JoséSales, A. M.Nery, J. A. C.Sarno, E. N.2012-06-13T19:27:08Z20080035-9203http://www.repositorio.ufba.br/ri/handle/ri/6122v. 102, v. 7Acesso restrito: Texto completo. p. 631-638The study assessed the effectiveness of BCG vaccination against leprosy among the contacts of 1161 leprosy patients at the FIOCRUZ Leprosy Outpatient Clinic, RJ, Brazil, from June 1987 to December 2006. Following National Leprosy Program guidelines, the clinic has administered one-to-two doses to all healthy contacts since 1991. Among the 5680 contacts, 304 (5.4%) already had leprosy. Of the 5376 eligible healthy contacts, 3536 were vaccinated, 30 of whom were excluded due to previous or current tuberculosis, or HIV. In 18 years of follow up, 122 (2.15%) incident cases were diagnosed (58 vaccinated and 64 not), 28 occurring in the first year of follow up (21 vaccinated, 16 with no scar). The protection conferred by BCG was 56% and was not substantially affected by previous BCG vaccination (50% with a scar and 59% without).The risk of tuberculoid leprosy during the initial months was high among those vaccinated with no scar. However, it had substantially declined by the first year and in the following years, when the protection rate in this group reached 80%. Since Brazil is endemic for leprosy and the detection rate is not declining satisfactorily, vaccinating all contacts could be an effective means of substantially reducing the incidence of leprosy. © 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. 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dc.title.pt_BR.fl_str_mv Effectiveness of BCG vaccination among leprosy contacts: a cohort study
dc.title.alternative.pt_BR.fl_str_mv Transactions of the royal society of tropical medicine and hygiene
title Effectiveness of BCG vaccination among leprosy contacts: a cohort study
spellingShingle Effectiveness of BCG vaccination among leprosy contacts: a cohort study
Düppre, N. C.
Leprosy
BCG
Vaccines
Effectiveness
Contact tracing
Brazil
title_short Effectiveness of BCG vaccination among leprosy contacts: a cohort study
title_full Effectiveness of BCG vaccination among leprosy contacts: a cohort study
title_fullStr Effectiveness of BCG vaccination among leprosy contacts: a cohort study
title_full_unstemmed Effectiveness of BCG vaccination among leprosy contacts: a cohort study
title_sort Effectiveness of BCG vaccination among leprosy contacts: a cohort study
author Düppre, N. C.
author_facet Düppre, N. C.
Camacho, Luiz Antonio Bastos
Cunha, Sérgio Souza da
Struchiner, Claudio José
Sales, A. M.
Nery, J. A. C.
Sarno, E. N.
author_role author
author2 Camacho, Luiz Antonio Bastos
Cunha, Sérgio Souza da
Struchiner, Claudio José
Sales, A. M.
Nery, J. A. C.
Sarno, E. N.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Düppre, N. C.
Camacho, Luiz Antonio Bastos
Cunha, Sérgio Souza da
Struchiner, Claudio José
Sales, A. M.
Nery, J. A. C.
Sarno, E. N.
Düppre, N. C.
Camacho, Luiz Antonio Bastos
Cunha, Sérgio Souza da
Struchiner, Claudio José
Sales, A. M.
Nery, J. A. C.
Sarno, E. N.
dc.subject.por.fl_str_mv Leprosy
BCG
Vaccines
Effectiveness
Contact tracing
Brazil
topic Leprosy
BCG
Vaccines
Effectiveness
Contact tracing
Brazil
description Acesso restrito: Texto completo. p. 631-638
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-06-13T19:27:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6122
dc.identifier.issn.none.fl_str_mv 0035-9203
dc.identifier.number.pt_BR.fl_str_mv v. 102, v. 7
identifier_str_mv 0035-9203
v. 102, v. 7
url http://www.repositorio.ufba.br/ri/handle/ri/6122
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.trstmh.2008.04.015
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