Inhibin B and Antim€ullerian Hormone as Markers of Gonadal Function after Treatment for Medulloblastoma or Posterior Fossa Ependymoma during Childhood

Detalhes bibliográficos
Autor(a) principal: Cuny, Ariane
Data de Publicação: 2011
Outros Autores: Trivin, Christine, Brailly-Tabard, Sylvie, Adan, Luís Fernando Fernandes, Zerah, Michel, Sainte-Rose, Christian, Alapetite, Claire, Brugières, Laurence, Habrand, Jean-Louis, Doz, François, Brauner, Raja
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5309
Resumo: Acesso restrito: Texto completo. p.1016-1022
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spelling Cuny, ArianeTrivin, ChristineBrailly-Tabard, SylvieAdan, Luís Fernando FernandesZerah, MichelSainte-Rose, ChristianAlapetite, ClaireBrugières, LaurenceHabrand, Jean-LouisDoz, FrançoisBrauner, RajaCuny, ArianeTrivin, ChristineBrailly-Tabard, SylvieAdan, Luís Fernando FernandesZerah, MichelSainte-Rose, ChristianAlapetite, ClaireBrugières, LaurenceHabrand, Jean-LouisDoz, FrançoisBrauner, Raja2012-02-07T17:51:53Z20110022-3476http://www.repositorio.ufba.br/ri/handle/ri/5309v. 158, n. 6.Acesso restrito: Texto completo. p.1016-1022Objective To evaluate the roles of hypothalamic-pituitary and spinal irradiations and chemotherapy in gonadal deficiency after treatment for medulloblastoma or posterior fossa ependymoma by measuring levels of plasma in- hibin B and antim€ullerian hormone (AMH). Study design A total of 34 boys and 22 girls were classified as having normal levels of plasma follicle-stimulating hormone (FSH; <9 IU/L), or abnormal levels of FSH (>9 IU/L) and luteinizing hormone (LH; <5 or >5 IUL). Results Two boys had partial gonadotropin deficiency, combined with testicular deficiency in one boy. Six boys had increased levels of FSH, indicating tubular deficiency, combined with Leydig cell deficiency in 5 boys. The 7 boys with inhibin B levels <100 ng/mL included the one with combined deficiencies and the 6 with testicular defi- ciency. Puberty did not progress in 7 girls; 3 had gonadotropin deficiency, combined with ovarian deficiency in one, and 4 had increased FSH levels, indicating ovarian deficiency. Inhibin B and AMH levels were low in the girl with combined deficiencies, in the 4 girls with ovarian deficiency, and in 4 girls with normal clinical-biological ovarian function, including 2 who underwent ovarian transposition before irradiation. Conclusion The plasma concentrations of inhibin B and AMH are useful means of detecting primary gonad de- ficiency in patients with no increase in their plasma gonadotropin levels because of radiation-induced gonadotropin deficiency. (J Pediatr 2011;158:1016-22).Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-02-07T17:51:53Z No. of bitstreams: 1 __pdn.sciencedirect.com_....0-S002234761000990X-main.pdf: 255497 bytes, checksum: 111b6c77e2c9495ed9df7f61498617ed (MD5)Made available in DSpace on 2012-02-07T17:51:53Z (GMT). No. of bitstreams: 1 __pdn.sciencedirect.com_....0-S002234761000990X-main.pdf: 255497 bytes, checksum: 111b6c77e2c9495ed9df7f61498617ed (MD5) Previous issue date: 2011DOI: 10.1016/j.jpeds.2010.11.019reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAInhibin B and Antim€ullerian Hormone as Markers of Gonadal Function after Treatment for Medulloblastoma or Posterior Fossa Ependymoma during ChildhoodJournal of pediatricsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL__pdn.sciencedirect.com_....0-S002234761000990X-main.pdf__pdn.sciencedirect.com_....0-S002234761000990X-main.pdfapplication/pdf255497https://repositorio.ufba.br/bitstream/ri/5309/1/__pdn.sciencedirect.com_....0-S002234761000990X-main.pdf111b6c77e2c9495ed9df7f61498617edMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5309/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT__pdn.sciencedirect.com_....0-S002234761000990X-main.pdf.txt__pdn.sciencedirect.com_....0-S002234761000990X-main.pdf.txtExtracted texttext/plain36906https://repositorio.ufba.br/bitstream/ri/5309/3/__pdn.sciencedirect.com_....0-S002234761000990X-main.pdf.txt96b50fc08461f6716e8ed0b879b84e40MD53ri/53092022-08-08 13:17:50.21oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Inhibin B and Antim€ullerian Hormone as Markers of Gonadal Function after Treatment for Medulloblastoma or Posterior Fossa Ependymoma during Childhood
dc.title.alternative.pt_BR.fl_str_mv Journal of pediatrics
title Inhibin B and Antim€ullerian Hormone as Markers of Gonadal Function after Treatment for Medulloblastoma or Posterior Fossa Ependymoma during Childhood
spellingShingle Inhibin B and Antim€ullerian Hormone as Markers of Gonadal Function after Treatment for Medulloblastoma or Posterior Fossa Ependymoma during Childhood
Cuny, Ariane
title_short Inhibin B and Antim€ullerian Hormone as Markers of Gonadal Function after Treatment for Medulloblastoma or Posterior Fossa Ependymoma during Childhood
title_full Inhibin B and Antim€ullerian Hormone as Markers of Gonadal Function after Treatment for Medulloblastoma or Posterior Fossa Ependymoma during Childhood
title_fullStr Inhibin B and Antim€ullerian Hormone as Markers of Gonadal Function after Treatment for Medulloblastoma or Posterior Fossa Ependymoma during Childhood
title_full_unstemmed Inhibin B and Antim€ullerian Hormone as Markers of Gonadal Function after Treatment for Medulloblastoma or Posterior Fossa Ependymoma during Childhood
title_sort Inhibin B and Antim€ullerian Hormone as Markers of Gonadal Function after Treatment for Medulloblastoma or Posterior Fossa Ependymoma during Childhood
author Cuny, Ariane
author_facet Cuny, Ariane
Trivin, Christine
Brailly-Tabard, Sylvie
Adan, Luís Fernando Fernandes
Zerah, Michel
Sainte-Rose, Christian
Alapetite, Claire
Brugières, Laurence
Habrand, Jean-Louis
Doz, François
Brauner, Raja
author_role author
author2 Trivin, Christine
Brailly-Tabard, Sylvie
Adan, Luís Fernando Fernandes
Zerah, Michel
Sainte-Rose, Christian
Alapetite, Claire
Brugières, Laurence
Habrand, Jean-Louis
Doz, François
Brauner, Raja
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cuny, Ariane
Trivin, Christine
Brailly-Tabard, Sylvie
Adan, Luís Fernando Fernandes
Zerah, Michel
Sainte-Rose, Christian
Alapetite, Claire
Brugières, Laurence
Habrand, Jean-Louis
Doz, François
Brauner, Raja
Cuny, Ariane
Trivin, Christine
Brailly-Tabard, Sylvie
Adan, Luís Fernando Fernandes
Zerah, Michel
Sainte-Rose, Christian
Alapetite, Claire
Brugières, Laurence
Habrand, Jean-Louis
Doz, François
Brauner, Raja
description Acesso restrito: Texto completo. p.1016-1022
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2012-02-07T17:51:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5309
dc.identifier.issn.none.fl_str_mv 0022-3476
dc.identifier.number.pt_BR.fl_str_mv v. 158, n. 6.
identifier_str_mv 0022-3476
v. 158, n. 6.
url http://www.repositorio.ufba.br/ri/handle/ri/5309
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv DOI: 10.1016/j.jpeds.2010.11.019
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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