Elevated airborne manganese and low executive function in school-aged children in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/17453 |
Resumo: | Texto completo: acesso restrito. p.301–308 |
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Carvalho, Chrissie Ferreira deMenezes Filho, José AntônioMatos, Vitor Parente deBessa, Jonatas ReisSantos, Juliana CoelhoViana, Gustavo Freitas de SousaArgollo, Nayara SilvaAbreu, José Neander SilvaCarvalho, Chrissie Ferreira deMenezes Filho, José AntônioMatos, Vitor Parente deBessa, Jonatas ReisSantos, Juliana CoelhoViana, Gustavo Freitas de SousaArgollo, Nayara SilvaAbreu, José Neander Silva2015-04-23T12:01:44Z20140161-813Xhttp://repositorio.ufba.br/ri/handle/ri/17453v. 45Texto completo: acesso restrito. p.301–308Exposure to airborne manganese (Mn) has been associated with neurotoxic effects, including motor and cognitive deficits. The main deficits related to excessive exposure to Mn are predominantly the dysfunction of fronto-striatal and dopaminergic circuits observed in animal experimental studies, which are involved in attention, working memory and motor function. The present study aims to assess the association between elevated Mn exposure and performance on executive function and attention neuropsychological tests in children living in two communities near a ferro-manganese alloy plant. Seventy children aged between 7 and 12 years with no history of neurologic disease and an estimated IQ >68 (Vocabulary and Block Design subtests) that had lived near the iron-Mn production alloy plant for at least 1.5 years were included. Participants were assessed for cognitive functioning with neuropsychological measures for sustained attention (Test of Visual Attention – TAVIS-3R), cognitive flexibility (WCST), and verbal and visual working memory (WISC-III Digit Span subtest and Corsi Block). Manganese hair (MnH) levels were used as a biomarker of exposure. Mean scores among study participants were lower than general population norms/averages for block design, digit span, reaction time and commission errors. The median MnH level was 11.48 (range 0.52–55.74) μg/g, and no difference between sexes was observed. Spearman's correlation analysis showed a significant inverse correlation between MnH levels and estimated IQ (rho = −0.448, p = 0.0001), Vocabulary (rho = −0.272, p = 0.02), Block Design (rho = −0.485, p = 0.00002) and Digit Span (rho = −0.410, p = 0.0004). Multiple regression analyses detected inverse associations between log MnH and scores on estimated IQ (β = −9.67; 95%CI = −16.97 to −2.37), Block Design (β = −2.50; 95%CI = −3.91 to −1.10) and Digit Span Total (β = −2.59; 95%CI = −4.13 to −1.05) standardized scores and the number of correct answers in forward and backward Digit Span methods, after adjusting for covariates (β = −1.32 = 95%CI = −2.23 to −0.40; β = −1.09 95%CI = −2.02 to −0.16, respectively). The results suggest that airborne Mn exposure may be associated with lower IQ and neuropsychological performance in tests of executive function of inhibition responses, strategic visual formation and verbal working memory. Executive function is dependent on the fronto-striatal circuit, which may be disrupted by Mn accumulation in the brain.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2015-03-24T12:29:25Z No. of bitstreams: 1 Chrissie F. Carvalho.pdf: 483547 bytes, checksum: 51aa9e9af35b8bc16f57b2296190332e (MD5)Approved for entry into archive by Oliveira Santos Dilzaná (dilznana@yahoo.com.br) on 2015-04-23T12:01:44Z (GMT) No. of bitstreams: 1 Chrissie F. Carvalho.pdf: 483547 bytes, checksum: 51aa9e9af35b8bc16f57b2296190332e (MD5)Made available in DSpace on 2015-04-23T12:01:44Z (GMT). No. of bitstreams: 1 Chrissie F. Carvalho.pdf: 483547 bytes, checksum: 51aa9e9af35b8bc16f57b2296190332e (MD5) Previous issue date: 2014http://dx.doi.org/10.1016/j.neuro.2013.11.006reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAManganeseNeurotoxicityExecutive functionChildrenNeuropsychologEnvironmental exposureElevated airborne manganese and low executive function in school-aged children in BrazilNeuroToxicologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01Brasilinfo:eu-repo/semantics/openAccessengORIGINALChrissie F. Carvalho.pdfChrissie F. Carvalho.pdfapplication/pdf483547https://repositorio.ufba.br/bitstream/ri/17453/1/Chrissie%20F.%20Carvalho.pdf51aa9e9af35b8bc16f57b2296190332eMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/17453/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTChrissie F. Carvalho.pdf.txtChrissie F. 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| dc.title.pt_BR.fl_str_mv |
Elevated airborne manganese and low executive function in school-aged children in Brazil |
| dc.title.alternative.pt_BR.fl_str_mv |
NeuroToxicology |
| title |
Elevated airborne manganese and low executive function in school-aged children in Brazil |
| spellingShingle |
Elevated airborne manganese and low executive function in school-aged children in Brazil Carvalho, Chrissie Ferreira de Manganese Neurotoxicity Executive function Children Neuropsycholog Environmental exposure |
| title_short |
Elevated airborne manganese and low executive function in school-aged children in Brazil |
| title_full |
Elevated airborne manganese and low executive function in school-aged children in Brazil |
| title_fullStr |
Elevated airborne manganese and low executive function in school-aged children in Brazil |
| title_full_unstemmed |
Elevated airborne manganese and low executive function in school-aged children in Brazil |
| title_sort |
Elevated airborne manganese and low executive function in school-aged children in Brazil |
| author |
Carvalho, Chrissie Ferreira de |
| author_facet |
Carvalho, Chrissie Ferreira de Menezes Filho, José Antônio Matos, Vitor Parente de Bessa, Jonatas Reis Santos, Juliana Coelho Viana, Gustavo Freitas de Sousa Argollo, Nayara Silva Abreu, José Neander Silva |
| author_role |
author |
| author2 |
Menezes Filho, José Antônio Matos, Vitor Parente de Bessa, Jonatas Reis Santos, Juliana Coelho Viana, Gustavo Freitas de Sousa Argollo, Nayara Silva Abreu, José Neander Silva |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carvalho, Chrissie Ferreira de Menezes Filho, José Antônio Matos, Vitor Parente de Bessa, Jonatas Reis Santos, Juliana Coelho Viana, Gustavo Freitas de Sousa Argollo, Nayara Silva Abreu, José Neander Silva Carvalho, Chrissie Ferreira de Menezes Filho, José Antônio Matos, Vitor Parente de Bessa, Jonatas Reis Santos, Juliana Coelho Viana, Gustavo Freitas de Sousa Argollo, Nayara Silva Abreu, José Neander Silva |
| dc.subject.por.fl_str_mv |
Manganese Neurotoxicity Executive function Children Neuropsycholog Environmental exposure |
| topic |
Manganese Neurotoxicity Executive function Children Neuropsycholog Environmental exposure |
| description |
Texto completo: acesso restrito. p.301–308 |
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2014 |
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2014 |
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2015-04-23T12:01:44Z |
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0161-813X |
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v. 45 |
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0161-813X v. 45 |
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