Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults

Detalhes bibliográficos
Autor(a) principal: Mello, Adriana Lima
Data de Publicação: 2012
Outros Autores: Cunha, Selma Freire de Carvalho da, Freitas, Maria Cristina Foss, Vannucchi, Helio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15036
Resumo: Texto completo: acesso restrito. p. 429-434
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spelling Mello, Adriana LimaCunha, Selma Freire de Carvalho daFreitas, Maria Cristina FossVannucchi, HelioMello, Adriana LimaCunha, Selma Freire de Carvalho daFreitas, Maria Cristina FossVannucchi, Helio2014-06-02T11:58:03Z20120004-2730http://repositorio.ufba.br/ri/handle/ri/15036v. 56, n. 7Texto completo: acesso restrito. p. 429-434OBJECTIVE: To determine plasma homocysteine levels during fasting and after methionine overload, and to correlate homocysteinemia according to methylenetetrahydrofolate reductase (MTHFR) polymorphism in type 2 diabetic adults. SUBJECTS AND METHODS: The study included 50 type 2 diabetic adults (DM group) and 52 healthy subjects (Control group). Anthropometric data, and information on food intake, serum levels of vitamin B12, folic acid and plasma homocysteine were obtained. The identification of C677T and A1298C polymorphisms was carried out in the MTHFR gene. RESULTS: There was no significant difference in homocysteinemia between the two groups, and hyperhomocysteinemia during fasting occurred in 40% of the diabetic patients and in 23% of the controls. For the same polymorphism, there was not any significant difference in homocysteine between the groups. In the Control group, homocysteinemia was greater in those subjects with C677T and A1298C polymorphisms. Among diabetic subjects, those with the A1298C polymorphism had lower levels of homocysteine compared with individuals with C677T polymorphism. CONCLUSION:The MTHFR polymorphism (C677T and A1298C) resulted in different outcomes regarding homocysteinemia among individuals of each group (diabetic and control). These data suggest that metabolic factors inherent to diabetes influence homocysteine metabolism.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-05-29T11:44:19Z No. of bitstreams: 1 Adriana Lima Mello.pdf: 128509 bytes, checksum: 6876dcea0634b84242bfaebb4fae3d26 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-06-02T11:58:03Z (GMT) No. of bitstreams: 1 Adriana Lima Mello.pdf: 128509 bytes, checksum: 6876dcea0634b84242bfaebb4fae3d26 (MD5)Made available in DSpace on 2014-06-02T11:58:03Z (GMT). No. of bitstreams: 1 Adriana Lima Mello.pdf: 128509 bytes, checksum: 6876dcea0634b84242bfaebb4fae3d26 (MD5) Previous issue date: 2012http://dx.doi.org/10.1590/S0004-27302012000700004reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBADiabetesHomocysteineMethylenetetrahydrofolate reductasePolymorphismDiabetes Mellitus, Type 2MethionineMethylenetetrahydrofolate Dehydrogenase (NADP)CystathionineHyperhomocysteinemiaEvaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adultsArquivos brasileiros de Endocrinologia e Metabologiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALAdriana Lima Mello.pdfAdriana Lima Mello.pdfapplication/pdf128509https://repositorio.ufba.br/bitstream/ri/15036/1/Adriana%20Lima%20Mello.pdf6876dcea0634b84242bfaebb4fae3d26MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15036/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTAdriana Lima Mello.pdf.txtAdriana Lima Mello.pdf.txtExtracted texttext/plain27221https://repositorio.ufba.br/bitstream/ri/15036/3/Adriana%20Lima%20Mello.pdf.txt3c00ea82a03b678f5f8096a36b4a525eMD53ri/150362022-07-05 14:03:30.844oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:30Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults
dc.title.alternative.pt_BR.fl_str_mv Arquivos brasileiros de Endocrinologia e Metabologia
title Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults
spellingShingle Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults
Mello, Adriana Lima
Diabetes
Homocysteine
Methylenetetrahydrofolate reductase
Polymorphism
Diabetes Mellitus, Type 2
Methionine
Methylenetetrahydrofolate Dehydrogenase (NADP)
Cystathionine
Hyperhomocysteinemia
title_short Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults
title_full Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults
title_fullStr Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults
title_full_unstemmed Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults
title_sort Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults
author Mello, Adriana Lima
author_facet Mello, Adriana Lima
Cunha, Selma Freire de Carvalho da
Freitas, Maria Cristina Foss
Vannucchi, Helio
author_role author
author2 Cunha, Selma Freire de Carvalho da
Freitas, Maria Cristina Foss
Vannucchi, Helio
author2_role author
author
author
dc.contributor.author.fl_str_mv Mello, Adriana Lima
Cunha, Selma Freire de Carvalho da
Freitas, Maria Cristina Foss
Vannucchi, Helio
Mello, Adriana Lima
Cunha, Selma Freire de Carvalho da
Freitas, Maria Cristina Foss
Vannucchi, Helio
dc.subject.por.fl_str_mv Diabetes
Homocysteine
Methylenetetrahydrofolate reductase
Polymorphism
Diabetes Mellitus, Type 2
Methionine
Methylenetetrahydrofolate Dehydrogenase (NADP)
Cystathionine
Hyperhomocysteinemia
topic Diabetes
Homocysteine
Methylenetetrahydrofolate reductase
Polymorphism
Diabetes Mellitus, Type 2
Methionine
Methylenetetrahydrofolate Dehydrogenase (NADP)
Cystathionine
Hyperhomocysteinemia
description Texto completo: acesso restrito. p. 429-434
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-06-02T11:58:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15036
dc.identifier.issn.none.fl_str_mv 0004-2730
dc.identifier.number.pt_BR.fl_str_mv v. 56, n. 7
identifier_str_mv 0004-2730
v. 56, n. 7
url http://repositorio.ufba.br/ri/handle/ri/15036
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0004-27302012000700004
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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