Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2004 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/17845 |
Resumo: | Texto completo: acesso restrito. p. 1797-1803 |
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Araujo, Maria Ilma Andrade SantosHoppe, BradfordMedeiros Junior, ManoelAlcântara, Leda MariaAlmeida, Maria Cecilia Freitas deSchriefer, Nicolaus Albert BorgesOliveira, Ricardo RiccioKruschewsky, Ramon de AlmeidaFigueiredo, Joanemile Pacheco deCruz Filho, Álvaro Augusto Souza daCarvalho Filho, Edgar Marcelino deAraujo, Maria Ilma Andrade SantosHoppe, BradfordMedeiros Junior, ManoelAlcântara, Leda MariaAlmeida, Maria Cecilia Freitas deSchriefer, Nicolaus Albert BorgesOliveira, Ricardo RiccioKruschewsky, Ramon de AlmeidaFigueiredo, Joanemile Pacheco deCruz Filho, Álvaro Augusto Souza daCarvalho Filho, Edgar Marcelino de2015-06-02T14:12:06Z20040022-1899http://repositorio.ufba.br/ri/handle/ri/17845v. 190, n. 10Texto completo: acesso restrito. p. 1797-1803Helminthic infections have been shown to inhibit allergy skin-prick tests and to modify the course of asthma. We evaluated Dermatophagoides pteronyssinus-specific immune responses in patients with asthma by measuring levels of T helper 2 (Th2) cytokines in peripheral blood mononuclear cell (PBMC) cultures. PBMCs from Schistosoma mansoni-infected patients with asthma living in an area of polyhelminthic endemicity produced lower levels of interleukin (IL)-5 and IL-4 in response to D. pteronyssinus antigen (Ag) 1 than did PBMCs from helminth-free patients with asthma. In contrast, D. pteronyssinus Ag 1-specific production of IL-10 was higher in helminth-infected patients than in helminth-free patients. The addition of recombinant human IL-10 to D. pteronyssinus Ag 1-stimulated cultures of PBMCs from helminth-free patients led to downmodulation of production of IL-5. After helminth-infected patients with asthma received antihelminthic treatment, there was down-modulation of D. pteronyssinus Ag 1-specific production of IL-10 in vitro. S. mansoni-infected patients with asthma produce lower levels of Th2 cytokines than do helminth-free patients with asthma, and this modulation is likely done by IL-10.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-12-02T13:03:12Z No. of bitstreams: 1 Edgar M. Carvalho.pdf: 444978 bytes, checksum: aaee175489e25d5e75c9f64ca5cd60f2 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2015-06-02T14:12:06Z (GMT) No. of bitstreams: 1 Edgar M. Carvalho.pdf: 444978 bytes, checksum: aaee175489e25d5e75c9f64ca5cd60f2 (MD5)Made available in DSpace on 2015-06-02T14:12:06Z (GMT). No. of bitstreams: 1 Edgar M. Carvalho.pdf: 444978 bytes, checksum: aaee175489e25d5e75c9f64ca5cd60f2 (MD5) Previous issue date: 2004http://dx.doi.org/10.1086/425017reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAsthmaInterleukin-4Interleukin-5AsmaInterleucina-4Th2 CellsInterleucina-5Células TH2Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with AsthmaJournal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALEdgar M. Carvalho.pdfEdgar M. Carvalho.pdfapplication/pdf444978https://repositorio.ufba.br/bitstream/ri/17845/1/Edgar%20M.%20Carvalho.pdfaaee175489e25d5e75c9f64ca5cd60f2MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/17845/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTEdgar M. Carvalho.pdf.txtEdgar M. 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| dc.title.pt_BR.fl_str_mv |
Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Infectious Diseases |
| title |
Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma |
| spellingShingle |
Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma Araujo, Maria Ilma Andrade Santos Asthma Interleukin-4 Interleukin-5 Asma Interleucina-4 Th2 Cells Interleucina-5 Células TH2 |
| title_short |
Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma |
| title_full |
Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma |
| title_fullStr |
Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma |
| title_full_unstemmed |
Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma |
| title_sort |
Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma |
| author |
Araujo, Maria Ilma Andrade Santos |
| author_facet |
Araujo, Maria Ilma Andrade Santos Hoppe, Bradford Medeiros Junior, Manoel Alcântara, Leda Maria Almeida, Maria Cecilia Freitas de Schriefer, Nicolaus Albert Borges Oliveira, Ricardo Riccio Kruschewsky, Ramon de Almeida Figueiredo, Joanemile Pacheco de Cruz Filho, Álvaro Augusto Souza da Carvalho Filho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Hoppe, Bradford Medeiros Junior, Manoel Alcântara, Leda Maria Almeida, Maria Cecilia Freitas de Schriefer, Nicolaus Albert Borges Oliveira, Ricardo Riccio Kruschewsky, Ramon de Almeida Figueiredo, Joanemile Pacheco de Cruz Filho, Álvaro Augusto Souza da Carvalho Filho, Edgar Marcelino de |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Araujo, Maria Ilma Andrade Santos Hoppe, Bradford Medeiros Junior, Manoel Alcântara, Leda Maria Almeida, Maria Cecilia Freitas de Schriefer, Nicolaus Albert Borges Oliveira, Ricardo Riccio Kruschewsky, Ramon de Almeida Figueiredo, Joanemile Pacheco de Cruz Filho, Álvaro Augusto Souza da Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos Hoppe, Bradford Medeiros Junior, Manoel Alcântara, Leda Maria Almeida, Maria Cecilia Freitas de Schriefer, Nicolaus Albert Borges Oliveira, Ricardo Riccio Kruschewsky, Ramon de Almeida Figueiredo, Joanemile Pacheco de Cruz Filho, Álvaro Augusto Souza da Carvalho Filho, Edgar Marcelino de |
| dc.subject.por.fl_str_mv |
Asthma Interleukin-4 Interleukin-5 Asma Interleucina-4 Th2 Cells Interleucina-5 Células TH2 |
| topic |
Asthma Interleukin-4 Interleukin-5 Asma Interleucina-4 Th2 Cells Interleucina-5 Células TH2 |
| description |
Texto completo: acesso restrito. p. 1797-1803 |
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2004 |
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2004 |
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2015-06-02T14:12:06Z |
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0022-1899 |
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v. 190, n. 10 |
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0022-1899 v. 190, n. 10 |
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