P16INK4a expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13494 |
Resumo: | Texto completo: acesso restrito.p.77–83 |
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Queiroz, Conceição MariaSilva, Tânia CorreiaAlves, Venâncio A. F.Costa, Maria CecíliaVilla, Luisa L.Travassos, Ana Gabriela ÁlvaresAraújo Filho, José BouzasStudart, EduardoCheto, TatianaFreitas, Luiz Antonio R. deQueiroz, Conceição MariaSilva, Tânia CorreiaAlves, Venâncio A. F.Costa, Maria CecíliaVilla, Luisa L.Travassos, Ana Gabriela ÁlvaresAraújo Filho, José BouzasStudart, EduardoCheto, TatianaFreitas, Luiz Antonio R. de2013-11-01T19:17:04Z20060344-0338http://repositorio.ufba.br/ri/handle/ri/13494v.222 n. 2Texto completo: acesso restrito.p.77–83An immunohistochemical analysis with monoclonal antibody p16INK4a was performed in formalin-fixed, paraffin-embedded samples of 60 cases. The aim was to investigate in biopsies the expression of p16INK4a of normal uterine cervical tissue, pre-cancerous and cancerous lesions, and their relation with human papilloma virus (HPV) and HIV status. Three parameters were evaluated: percentage of p16INK4a positive cells, reaction intensity, and cell staining pattern. All of these parameters were statistically different when compared among different histological groups. However, logistic regression model showed that the reaction intensity was the best indicator of the expression of p16INK4a. This expression increases from normal to invasive squamous carcinoma. Sixty-six percent of the patients with CIN grade 1 (CIN1) expressed p16INK4a (all these cases were infected with high risk HPV). Our study supports the hypothesis that p16INK4a expression in pre-cancerous lesions and cancers can be used to identify HPV-transformed cells. Of great interest for routine diagnostic use is the fact that immunohistochemical testing for p16INK4a seems to be capable of identifying HPV-positive cells and potentially recognizing those lesions with an increased risk of progression to high-grade lesions.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-08-29T17:55:11Z No. of bitstreams: 1 1-s2.0-S0344033805002165-main.pdf: 358121 bytes, checksum: ec8e0da03a8e7fff83c795995020a74f (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-01T19:17:04Z (GMT) No. of bitstreams: 1 1-s2.0-S0344033805002165-main.pdf: 358121 bytes, checksum: ec8e0da03a8e7fff83c795995020a74f (MD5)Made available in DSpace on 2013-11-01T19:17:04Z (GMT). No. of bitstreams: 1 1-s2.0-S0344033805002165-main.pdf: 358121 bytes, checksum: ec8e0da03a8e7fff83c795995020a74f (MD5) Previous issue date: 2006http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.prp.2005.08.012reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACervical neoplasiaDiagnostic markerp16INK4Human papillomavirusHuman immunodeficiency virusP16INK4a expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesionsPathology - Research and Practiceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S0344033805002165-main.pdf1-s2.0-S0344033805002165-main.pdfapplication/pdf358121https://repositorio.ufba.br/bitstream/ri/13494/1/1-s2.0-S0344033805002165-main.pdfec8e0da03a8e7fff83c795995020a74fMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13494/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT1-s2.0-S0344033805002165-main.pdf.txt1-s2.0-S0344033805002165-main.pdf.txtExtracted texttext/plain29574https://repositorio.ufba.br/bitstream/ri/13494/3/1-s2.0-S0344033805002165-main.pdf.txt94187e7b8d327c7b440b8c3089443d63MD53ri/134942022-07-05 14:02:57.653oai:repositorio.ufba.br:ri/13494VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIHJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBCgogICAgUGVsbyBwcm9jZXNzbyBkZSBzdWJtaXNz77+9byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldQpyZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBjb25jZWRlIGFvClJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSBvIGRpcmVpdG8KZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCAKZGUgcHJlc2VydmHvv73vv71vLiBFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIAphdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIGNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4gCgogICAgUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVp77+977+9bywgZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEgZW50ZW5kZSBxdWU6IAoKICAgIE1hbnRlbmRvIG9zICBkaXJlaXRvcyBhdXRvcmFpcywgcmVwYXNzYWRvcyBhIHRlcmNlaXJvcywgZW0gY2FzbyAKZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8gcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIAppbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1h77+977+9ZXMgc29icmUgbyBkb2N1bWVudG8gKE1ldGFkYWRvcyBkZXNjcml0aXZvcykuCgogRGVzdGEgZm9ybWEsIGF0ZW5kZW5kbyBhb3MgYW5zZWlvcyBkZXNzYSB1bml2ZXJzaWRhZGUgCmVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gYXMgcmVzdHJp77+977+9ZXMgaW1wb3N0YXMgcGVsb3MgCmVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4gCgogICAgUGFyYSBhcyBwdWJsaWNh77+977+9ZXMgZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgCkFjZXNzbyBBYmVydG8sIG9zIGRlcO+/vXNpdG9zIGNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gCm9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudO+/vW0gbyBhY2Vzc28gaXJyZXN0cml0byBhbyBtZXRhZGFkb3MgCmUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIApjb25zZW50aW1lbnRvIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgCmVzdGFyZW0gZW0gaW5pY2lhdGl2YXMgZGUgYWNlc3NvIGFiZXJ0by4KCiAgICBFbSBhbWJvcyBvIGNhc28sIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBwb2RlIHNlciBhY2VpdG8gcGVsbyAKYXV0b3IsIGRldGVudG9yZXMgZGUgZGlyZWl0b3MgZS9vdSB0ZXJjZWlyb3MgYW1wYXJhZG9zIHBlbGEgCnVuaXZlcnNpZGFkZS4gRGV2aWRvIGFvcyBkaWZlcmVudGVzIHByb2Nlc3NvcyBwZWxvIHF1YWwgYSBzdWJtaXNz77+9byAKcG9kZSBvY29ycmVyLCBvIHJlcG9zaXTvv71yaW8gcGVybWl0ZSBhIGFjZWl0Ye+/ve+/vW8gZGEgbGljZW7vv71hIHBvciAKdGVyY2Vpcm9zLCBzb21lbnRlIG5vcyBjYXNvcyBkZSBkb2N1bWVudG9zIHByb2R1emlkb3MgcG9yIGludGVncmFudGVzIApkYSBVRkJBIGUgc3VibWV0aWRvcyBwb3IgcGVzc29hcyBhbXBhcmFkYXMgcG9yIGVzdGEgaW5zdGl0dWnvv73vv71vLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:57Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
P16INK4a expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions |
| dc.title.alternative.pt_BR.fl_str_mv |
Pathology - Research and Practice |
| title |
P16INK4a expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions |
| spellingShingle |
P16INK4a expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions Queiroz, Conceição Maria Cervical neoplasia Diagnostic marker p16INK4 Human papillomavirus Human immunodeficiency virus |
| title_short |
P16INK4a expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions |
| title_full |
P16INK4a expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions |
| title_fullStr |
P16INK4a expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions |
| title_full_unstemmed |
P16INK4a expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions |
| title_sort |
P16INK4a expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions |
| author |
Queiroz, Conceição Maria |
| author_facet |
Queiroz, Conceição Maria Silva, Tânia Correia Alves, Venâncio A. F. Costa, Maria Cecília Villa, Luisa L. Travassos, Ana Gabriela Álvares Araújo Filho, José Bouzas Studart, Eduardo Cheto, Tatiana Freitas, Luiz Antonio R. de |
| author_role |
author |
| author2 |
Silva, Tânia Correia Alves, Venâncio A. F. Costa, Maria Cecília Villa, Luisa L. Travassos, Ana Gabriela Álvares Araújo Filho, José Bouzas Studart, Eduardo Cheto, Tatiana Freitas, Luiz Antonio R. de |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Queiroz, Conceição Maria Silva, Tânia Correia Alves, Venâncio A. F. Costa, Maria Cecília Villa, Luisa L. Travassos, Ana Gabriela Álvares Araújo Filho, José Bouzas Studart, Eduardo Cheto, Tatiana Freitas, Luiz Antonio R. de Queiroz, Conceição Maria Silva, Tânia Correia Alves, Venâncio A. F. Costa, Maria Cecília Villa, Luisa L. Travassos, Ana Gabriela Álvares Araújo Filho, José Bouzas Studart, Eduardo Cheto, Tatiana Freitas, Luiz Antonio R. de |
| dc.subject.por.fl_str_mv |
Cervical neoplasia Diagnostic marker p16INK4 Human papillomavirus Human immunodeficiency virus |
| topic |
Cervical neoplasia Diagnostic marker p16INK4 Human papillomavirus Human immunodeficiency virus |
| description |
Texto completo: acesso restrito.p.77–83 |
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2006 |
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2006 |
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2013-11-01T19:17:04Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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0344-0338 |
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v.222 n. 2 |
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