Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus

Detalhes bibliográficos
Autor(a) principal: Brandão, Flávia R.
Data de Publicação: 2007
Outros Autores: Vicente, Eliezer J., Daltro, Carla Hilário da Cunha, Sacramento, Marisa, Moreira, Agnaluce, Adan, Luís Fernando Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14312
Resumo: Texto completo: acesso restrito. p. 334-339
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spelling Brandão, Flávia R.Vicente, Eliezer J.Daltro, Carla Hilário da CunhaSacramento, MarisaMoreira, AgnaluceAdan, Luís Fernando FernandesBrandão, Flávia R.Vicente, Eliezer J.Daltro, Carla Hilário da CunhaSacramento, MarisaMoreira, AgnaluceAdan, Luís Fernando Fernandes2014-01-10T16:18:13Z20070168-8227http://repositorio.ufba.br/ri/handle/ri/14312v. 78, n. 3Texto completo: acesso restrito. p. 334-339This cross-sectional study analyzed bone mineral density (BMD) in children and adolescents with type 1 diabetes mellitus (DM1) and its relationship with metabolic control, duration of disease and bone markers. Methods: Forty-four children and adolescents with DM1 (age 8.8 ± 4.4 years, disease duration 6.6 ± 3.9 years) and 22 healthy children were assessed for BMD of the lumbar spine (L1–L4) by dual energy X-ray absorptiometry; osteocalcin (OC) and carboxy-terminal telopeptide (CTX) were measured in the study group. Results: The BMD was similar in subjects with (−1.15 ± 1.2 S.D.) and without DM1 (−0.85 ± 0.88 S.D., p = 0.25). After adjustment for weight, height and pubertal development, the BMD was <−2.0 S.D. in only two diabetic patients (4.5%). Bone area (BA) was inversely correlated with the duration of diabetes (p = 0.03) and HbA1c (p = 0.02). In girls, who presented a worse HbA1c than boys (p < 0.01), BMD was inversely correlated with HbA1c (p = 0.05). OC and CTX levels were higher in boys (p < 0.01) and both inversely correlated with pubertal development (p = 0.01), but not with BMD. Conclusions: Children and adolescents with DM1 have normal bone mass in the lumbar spine. However, longer diabetes duration and poor metabolic control may have a negative impact on bone mass, requiring further investigation through longitudinal studies.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-06T13:15:11Z No. of bitstreams: 1 1-s2.0-S0168822707002987-main.pdf: 284633 bytes, checksum: d3bec8e8c5a62eef570569d9a493cb66 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-10T16:18:12Z (GMT) No. of bitstreams: 1 1-s2.0-S0168822707002987-main.pdf: 284633 bytes, checksum: d3bec8e8c5a62eef570569d9a493cb66 (MD5)Made available in DSpace on 2014-01-10T16:18:13Z (GMT). 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dc.title.pt_BR.fl_str_mv Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus
dc.title.alternative.pt_BR.fl_str_mv Diabetes Research and Clinical Practice
title Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus
spellingShingle Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus
Brandão, Flávia R.
Bone mineral density
Type 1 diabetes mellitus
Osteopenia
Metabolic control
Bone markers
title_short Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus
title_full Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus
title_fullStr Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus
title_full_unstemmed Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus
title_sort Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus
author Brandão, Flávia R.
author_facet Brandão, Flávia R.
Vicente, Eliezer J.
Daltro, Carla Hilário da Cunha
Sacramento, Marisa
Moreira, Agnaluce
Adan, Luís Fernando Fernandes
author_role author
author2 Vicente, Eliezer J.
Daltro, Carla Hilário da Cunha
Sacramento, Marisa
Moreira, Agnaluce
Adan, Luís Fernando Fernandes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Brandão, Flávia R.
Vicente, Eliezer J.
Daltro, Carla Hilário da Cunha
Sacramento, Marisa
Moreira, Agnaluce
Adan, Luís Fernando Fernandes
Brandão, Flávia R.
Vicente, Eliezer J.
Daltro, Carla Hilário da Cunha
Sacramento, Marisa
Moreira, Agnaluce
Adan, Luís Fernando Fernandes
dc.subject.por.fl_str_mv Bone mineral density
Type 1 diabetes mellitus
Osteopenia
Metabolic control
Bone markers
topic Bone mineral density
Type 1 diabetes mellitus
Osteopenia
Metabolic control
Bone markers
description Texto completo: acesso restrito. p. 334-339
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-01-10T16:18:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14312
dc.identifier.issn.none.fl_str_mv 0168-8227
dc.identifier.number.pt_BR.fl_str_mv v. 78, n. 3
identifier_str_mv 0168-8227
v. 78, n. 3
url http://repositorio.ufba.br/ri/handle/ri/14312
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.diabres.2007.04.009
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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