Ethnicity and glutathione S-transferase (GSTM1/GSTT1) polymorphisms in a Brazilian population

Detalhes bibliográficos
Autor(a) principal: Gattás, G. J. F.
Data de Publicação: 2004
Outros Autores: Kato, M., Vieira, J. A. Soares, Siraque, M. S., Kohler, P., Gomes, L., Rêgo, Marco Antônio Vasconcelos, Bydlowski, S. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/3874
Resumo: p. 451-458.
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spelling Gattás, G. J. F.Kato, M.Vieira, J. A. SoaresSiraque, M. S.Kohler, P.Gomes, L.Rêgo, Marco Antônio VasconcelosBydlowski, S. P.Gattás, G. J. F.Kato, M.Vieira, J. A. SoaresSiraque, M. S.Kohler, P.Gomes, L.Rêgo, Marco Antônio VasconcelosBydlowski, S. P.2011-11-25T12:07:44Z2011-11-25T12:07:44Z20040100-879Xhttp://www.repositorio.ufba.br/ri/handle/ri/387437(4)p. 451-458.The distribution of polymorphisms related to glutathione S-transferases (GST) has been described in different populations, mainly for white individuals. We evaluated the distribution of GST mu (GSTM1) and theta (GSTT1) genotypes in 594 individuals, by multiplex PCRbased methods, using amplification of the exon 7 of CYP1A1 gene as an internal control. In São Paulo, 233 whites, 87 mulattos, and 137 blacks, all healthy blood-donor volunteers, were tested. In Bahia, where black and mulatto populations are more numerous, 137 subjects were evaluated. The frequency of the GSTM1 null genotype was significantly higher among whites (55.4%) than among mulattos (41.4%; P = 0.03) and blacks (32.8%; P < 0.0001) from São Paulo, or Bahian subjects in general (35.7%; P = 0.0003). There was no statistically different distribution among any non-white groups. The distribution of GSTT1 null genotype among groups did not differ significantly. The agreement between self-reported and interviewer classification of skin color in the Bahian group was low. The interviewer classification indicated a gradient of distribution of the GSTM1 null genotype from whites (55.6%) to light mulattos (40.4%), dark mulattos (32.0%) and blacks (28.6%). However, any information about race or ethnicity should be considered with caution regarding the bias introduced by different data collection techniques, specially in countries where racial admixture is intense, and ethnic definition boundaries are loose. Because homozygous deletions of GST gene might be associated with cancer risk, a better understanding of chemical metabolizing gene distribution can contribute to risk assessment of humans exposed to environmental carcinogens.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2011-11-25T12:07:44Z No. of bitstreams: 1 5159.pdf: 612642 bytes, checksum: 6576d7f9e2b39be449f4a01fc06a48ff (MD5)Made available in DSpace on 2011-11-25T12:07:44Z (GMT). No. of bitstreams: 1 5159.pdf: 612642 bytes, checksum: 6576d7f9e2b39be449f4a01fc06a48ff (MD5) Previous issue date: 2004Glutathione S-transferase mu (GSTM1)Glutathione S-transferase theta (GSTT1)Enzyme polymorphismPopulation frequencyEthnicityBrazilEthnicity and glutathione S-transferase (GSTM1/GSTT1) polymorphisms in a Brazilian populationBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1918https://repositorio.ufba.br/bitstream/ri/3874/2/license.txt89ee22d508b686081142bac7822badebMD52ORIGINAL029__pdf[1].pdf029__pdf[1].pdfapplication/pdf612642https://repositorio.ufba.br/bitstream/ri/3874/3/029__pdf%5b1%5d.pdf6576d7f9e2b39be449f4a01fc06a48ffMD53TEXT029__pdf[1].pdf.txt029__pdf[1].pdf.txtExtracted texttext/plain31136https://repositorio.ufba.br/bitstream/ri/3874/4/029__pdf%5b1%5d.pdf.txtca82248cb16b0f8123ced9f41fb190efMD54ri/38742022-07-05 14:04:04.81oai:repositorio.ufba.br:ri/3874Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:04Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Ethnicity and glutathione S-transferase (GSTM1/GSTT1) polymorphisms in a Brazilian population
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
title Ethnicity and glutathione S-transferase (GSTM1/GSTT1) polymorphisms in a Brazilian population
spellingShingle Ethnicity and glutathione S-transferase (GSTM1/GSTT1) polymorphisms in a Brazilian population
Gattás, G. J. F.
Glutathione S-transferase mu (GSTM1)
Glutathione S-transferase theta (GSTT1)
Enzyme polymorphism
Population frequency
Ethnicity
Brazil
title_short Ethnicity and glutathione S-transferase (GSTM1/GSTT1) polymorphisms in a Brazilian population
title_full Ethnicity and glutathione S-transferase (GSTM1/GSTT1) polymorphisms in a Brazilian population
title_fullStr Ethnicity and glutathione S-transferase (GSTM1/GSTT1) polymorphisms in a Brazilian population
title_full_unstemmed Ethnicity and glutathione S-transferase (GSTM1/GSTT1) polymorphisms in a Brazilian population
title_sort Ethnicity and glutathione S-transferase (GSTM1/GSTT1) polymorphisms in a Brazilian population
author Gattás, G. J. F.
author_facet Gattás, G. J. F.
Kato, M.
Vieira, J. A. Soares
Siraque, M. S.
Kohler, P.
Gomes, L.
Rêgo, Marco Antônio Vasconcelos
Bydlowski, S. P.
author_role author
author2 Kato, M.
Vieira, J. A. Soares
Siraque, M. S.
Kohler, P.
Gomes, L.
Rêgo, Marco Antônio Vasconcelos
Bydlowski, S. P.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gattás, G. J. F.
Kato, M.
Vieira, J. A. Soares
Siraque, M. S.
Kohler, P.
Gomes, L.
Rêgo, Marco Antônio Vasconcelos
Bydlowski, S. P.
Gattás, G. J. F.
Kato, M.
Vieira, J. A. Soares
Siraque, M. S.
Kohler, P.
Gomes, L.
Rêgo, Marco Antônio Vasconcelos
Bydlowski, S. P.
dc.subject.por.fl_str_mv Glutathione S-transferase mu (GSTM1)
Glutathione S-transferase theta (GSTT1)
Enzyme polymorphism
Population frequency
Ethnicity
Brazil
topic Glutathione S-transferase mu (GSTM1)
Glutathione S-transferase theta (GSTT1)
Enzyme polymorphism
Population frequency
Ethnicity
Brazil
description p. 451-458.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2011-11-25T12:07:44Z
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dc.identifier.issn.none.fl_str_mv 0100-879X
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