Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14746 |
Resumo: | Texto completo: acesso restrito. p. 145–151 |
| id |
UFBA-2_fbd61f5ad771caa19b1ba60e1863f15c |
|---|---|
| oai_identifier_str |
oai:repositorio.ufba.br:ri/14746 |
| network_acronym_str |
UFBA-2 |
| network_name_str |
Repositório Institucional da UFBA |
| repository_id_str |
1932 |
| spelling |
Santos, Silvane Maria BragaPorto, Maria Aurélia da FonsecaMuniz, André Luís NunesLuna, TaniaNascimento, Márcia C.Guerreiro, Jaqueline B.OliveiraFilho, JamaryMorgan, Daniel J.Carvalho Filho, Edgar Marcelino deSantos, Silvane Maria BragaPorto, Maria Aurélia da FonsecaMuniz, André Luís NunesLuna, TaniaNascimento, Márcia C.Guerreiro, Jaqueline B.OliveiraFilho, JamaryMorgan, Daniel J.Carvalho Filho, Edgar Marcelino de2014-03-13T18:22:22Z20071021-7401http://repositorio.ufba.br/ri/handle/ri/14746v. 13, n. 3Texto completo: acesso restrito. p. 145–151Objective: Human T lymphotropic virus-type 1 (HTLV-1) activates the immune system leading to a persistent and exacerbated T-cell response with increased production of IFN-γ and TNF-α. Overproduction of pro-inflammatory cytokines is correlated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although some HTLV-1 carriers also show high levels of these cytokines. In this study, the ability of regulatory cytokines and cytokine antagonists to inhibit spontaneous IFN-γ production was investigated. Method: IFN-γ levels were measured by ELISA before and after addition of cytokines or anti-cytokines. Results: Addition of IL-10 significantly reduced spontaneous IFN-γ synthesis in cell cultures from HTLV-1 carriers, while no differences were observed in HAM/TSP patients. There was also a tendency to decreased IFN-γ levels in cell cultures from HTLV-1 carriers with exogenous addition of TGF-β. In paired analysis, neutralization of IL-2 significantly decreased IFN-γ production in HTLV-1 carriers but not in HAM/TSP patients. Neutralization of IL-15 was less effective than neutralization of IL-2 in modulating IFN-γ production. In HTLV-1 carriers, anti-IL-2 and simultaneous addition of anti-IL-2 and anti-IL-15 decreased IFN-γ synthesis by 46 and 64%, respectively, whereas in patients with HAM/TSP simultaneous neutralization of both anti-cytokines only decrease IFN-γ levels by 27%. Conclusions: Although a large proportion of HTLV-1 carriers produced high levels of pro-inflammatory cytokines similar to those observed in HAM/TSP patients, immune response can be downregulated by cytokines or cytokine antagonists in most HTLV-1 carriers. This modulation can be an important step in the prevention of tissue damage and progression from the HTLV-1 carrier state to HAM/TSP.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-03-12T14:17:29Z No. of bitstreams: 1 10.1159000097259.pdf: 156614 bytes, checksum: 18363f14d2b5df5b1ef9a4d5984aac03 (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-03-13T18:22:21Z (GMT) No. of bitstreams: 1 10.1159000097259.pdf: 156614 bytes, checksum: 18363f14d2b5df5b1ef9a4d5984aac03 (MD5)Made available in DSpace on 2014-03-13T18:22:22Z (GMT). No. of bitstreams: 1 10.1159000097259.pdf: 156614 bytes, checksum: 18363f14d2b5df5b1ef9a4d5984aac03 (MD5) Previous issue date: 2007http://dx.doi.org/10.1159/000097259reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAntagonistsCytokinesHTLV-1Interferon-γMyelopathyT cell responsesModulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1Neuroimmunomodulationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14746/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINAL10.1159000097259.pdf10.1159000097259.pdfapplication/pdf156614https://repositorio.ufba.br/bitstream/ri/14746/1/10.1159000097259.pdf18363f14d2b5df5b1ef9a4d5984aac03MD51TEXT10.1159000097259.pdf.txt10.1159000097259.pdf.txtExtracted texttext/plain32033https://repositorio.ufba.br/bitstream/ri/14746/3/10.1159000097259.pdf.txta0f66474613e44a9586cd065cebddefaMD53ri/147462022-07-05 14:03:13.027oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1 |
| dc.title.alternative.pt_BR.fl_str_mv |
Neuroimmunomodulation |
| title |
Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1 |
| spellingShingle |
Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1 Santos, Silvane Maria Braga Antagonists Cytokines HTLV-1 Interferon-γ Myelopathy T cell responses |
| title_short |
Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1 |
| title_full |
Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1 |
| title_fullStr |
Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1 |
| title_full_unstemmed |
Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1 |
| title_sort |
Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1 |
| author |
Santos, Silvane Maria Braga |
| author_facet |
Santos, Silvane Maria Braga Porto, Maria Aurélia da Fonseca Muniz, André Luís Nunes Luna, Tania Nascimento, Márcia C. Guerreiro, Jaqueline B. OliveiraFilho, Jamary Morgan, Daniel J. Carvalho Filho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Porto, Maria Aurélia da Fonseca Muniz, André Luís Nunes Luna, Tania Nascimento, Márcia C. Guerreiro, Jaqueline B. OliveiraFilho, Jamary Morgan, Daniel J. Carvalho Filho, Edgar Marcelino de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Silvane Maria Braga Porto, Maria Aurélia da Fonseca Muniz, André Luís Nunes Luna, Tania Nascimento, Márcia C. Guerreiro, Jaqueline B. OliveiraFilho, Jamary Morgan, Daniel J. Carvalho Filho, Edgar Marcelino de Santos, Silvane Maria Braga Porto, Maria Aurélia da Fonseca Muniz, André Luís Nunes Luna, Tania Nascimento, Márcia C. Guerreiro, Jaqueline B. OliveiraFilho, Jamary Morgan, Daniel J. Carvalho Filho, Edgar Marcelino de |
| dc.subject.por.fl_str_mv |
Antagonists Cytokines HTLV-1 Interferon-γ Myelopathy T cell responses |
| topic |
Antagonists Cytokines HTLV-1 Interferon-γ Myelopathy T cell responses |
| description |
Texto completo: acesso restrito. p. 145–151 |
| publishDate |
2007 |
| dc.date.issued.fl_str_mv |
2007 |
| dc.date.accessioned.fl_str_mv |
2014-03-13T18:22:22Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/14746 |
| dc.identifier.issn.none.fl_str_mv |
1021-7401 |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 13, n. 3 |
| identifier_str_mv |
1021-7401 v. 13, n. 3 |
| url |
http://repositorio.ufba.br/ri/handle/ri/14746 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.pt_BR.fl_str_mv |
http://dx.doi.org/10.1159/000097259 |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
| instname_str |
Universidade Federal da Bahia (UFBA) |
| instacron_str |
UFBA |
| institution |
UFBA |
| reponame_str |
Repositório Institucional da UFBA |
| collection |
Repositório Institucional da UFBA |
| bitstream.url.fl_str_mv |
https://repositorio.ufba.br/bitstream/ri/14746/2/license.txt https://repositorio.ufba.br/bitstream/ri/14746/1/10.1159000097259.pdf https://repositorio.ufba.br/bitstream/ri/14746/3/10.1159000097259.pdf.txt |
| bitstream.checksum.fl_str_mv |
0d4b811ef71182510d2015daa7c8a900 18363f14d2b5df5b1ef9a4d5984aac03 a0f66474613e44a9586cd065cebddefa |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA) |
| repository.mail.fl_str_mv |
|
| _version_ |
1798057653910372352 |