Effect of a cholesterol-rich diet on the metabolism of the free and esterified cholesterol components of a nanoemulsion that resembles LDL in rabbits

Detalhes bibliográficos
Autor(a) principal: Padoveze, A. F.
Data de Publicação: 2009
Outros Autores: Maniero, F., Oliveira, T. V., Vitorio, T. S., Couto, Ricardo David, Maranhão, R. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5835
Resumo: p. 172-178
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spelling Padoveze, A. F.Maniero, F.Oliveira, T. V.Vitorio, T. S.Couto, Ricardo DavidMaranhão, R. C.Padoveze, A. F.Maniero, F.Oliveira, T. V.Vitorio, T. S.Couto, Ricardo DavidMaranhão, R. C.2012-05-11T13:23:27Z2012-05-11T13:23:27Z20091414-431Xhttp://www.repositorio.ufba.br/ri/handle/ri/5835v. 42, n. 2.p. 172-178We have shown that the free cholesterol (FC) and the cholesteryl ester (CE) moieties of a nanoemulsion with lipidic structure resembling low-density lipoproteins show distinct metabolic fate in subjects and that this may be related to the presence of dyslipidemia and atherosclerosis. The question was raised whether induction of hyperlipidemia and atherosclerosis in rabbits would affect the metabolic behavior of the two cholesterol forms. Male New Zealand rabbits aged 4-5 months were allocated to a control group (N = 17) fed regular chow and to a 1% cholesterol-fed group (N = 13) during a 2-month period. Subsequently, the nanoemulsion labeled with 3H-FC and 14C-CE was injected intravenously for the determination of plasma kinetics and tissue uptake of the radioactive labels. In controls, FC and CE had similar plasma kinetics (fractional clearance rate, FCR = 0.234 ± 0.056 and 0.170 ± 0.038 h-1, respectively; P = 0.065). In cholesterol-fed rabbits, the clearance of both labels was delayed and, as a remarkable feature, FC-FCR (0.089 ± 0.033 h-1) was considerably greater than CE-FCR (0.046 ± 0.010 h-1; P = 0.026). In the liver, the major nanoemulsion uptake site, uptake of the labels was similar in control animals (FC = 0.2256 ± 0.1475 and CE = 0.2135 ± 0.1580%/g) but in cholesterol-fed animals FC uptake (0.0890 ± 0.0319%/g) was greater than CE uptake (0.0595 ± 0.0207%/g; P < 0.05). Therefore, whereas in controls, FC and CE have similar metabolism, the induction of dyslipidemia and atherosclerosis resulted in dissociation of the two forms of cholesterol.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-11T13:23:27Z No. of bitstreams: 1 __www.scielo.br_pdf_bjmbr_v42n2_7214.pdf: 131304 bytes, checksum: e77af3c92aa8ae59e4b2f76ae0bc5aa4 (MD5)Made available in DSpace on 2012-05-11T13:23:27Z (GMT). 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dc.title.pt_BR.fl_str_mv Effect of a cholesterol-rich diet on the metabolism of the free and esterified cholesterol components of a nanoemulsion that resembles LDL in rabbits
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
title Effect of a cholesterol-rich diet on the metabolism of the free and esterified cholesterol components of a nanoemulsion that resembles LDL in rabbits
spellingShingle Effect of a cholesterol-rich diet on the metabolism of the free and esterified cholesterol components of a nanoemulsion that resembles LDL in rabbits
Padoveze, A. F.
Lipoprotein kinetics
Free cholesterol
Hyperlipidemia
Rabbit atherosclerosis
Nanoemulsions
Cholesterol-rich diet
title_short Effect of a cholesterol-rich diet on the metabolism of the free and esterified cholesterol components of a nanoemulsion that resembles LDL in rabbits
title_full Effect of a cholesterol-rich diet on the metabolism of the free and esterified cholesterol components of a nanoemulsion that resembles LDL in rabbits
title_fullStr Effect of a cholesterol-rich diet on the metabolism of the free and esterified cholesterol components of a nanoemulsion that resembles LDL in rabbits
title_full_unstemmed Effect of a cholesterol-rich diet on the metabolism of the free and esterified cholesterol components of a nanoemulsion that resembles LDL in rabbits
title_sort Effect of a cholesterol-rich diet on the metabolism of the free and esterified cholesterol components of a nanoemulsion that resembles LDL in rabbits
author Padoveze, A. F.
author_facet Padoveze, A. F.
Maniero, F.
Oliveira, T. V.
Vitorio, T. S.
Couto, Ricardo David
Maranhão, R. C.
author_role author
author2 Maniero, F.
Oliveira, T. V.
Vitorio, T. S.
Couto, Ricardo David
Maranhão, R. C.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Padoveze, A. F.
Maniero, F.
Oliveira, T. V.
Vitorio, T. S.
Couto, Ricardo David
Maranhão, R. C.
Padoveze, A. F.
Maniero, F.
Oliveira, T. V.
Vitorio, T. S.
Couto, Ricardo David
Maranhão, R. C.
dc.subject.por.fl_str_mv Lipoprotein kinetics
Free cholesterol
Hyperlipidemia
Rabbit atherosclerosis
Nanoemulsions
Cholesterol-rich diet
topic Lipoprotein kinetics
Free cholesterol
Hyperlipidemia
Rabbit atherosclerosis
Nanoemulsions
Cholesterol-rich diet
description p. 172-178
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2012-05-11T13:23:27Z
dc.date.available.fl_str_mv 2012-05-11T13:23:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5835
dc.identifier.issn.none.fl_str_mv 1414-431X
dc.identifier.number.pt_BR.fl_str_mv v. 42, n. 2.
identifier_str_mv 1414-431X
v. 42, n. 2.
url http://www.repositorio.ufba.br/ri/handle/ri/5835
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2009000200005
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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reponame_str Repositório Institucional da UFBA
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