Prevalence of drug-resistant tuberculosis and associated factors

Detalhes bibliográficos
Autor(a) principal: Sousa, George Jó Bezerra
Data de Publicação: 2021
Outros Autores: Maranhão, Thatiana Araújo, Leitão, Terezinha do Menino Jesus Silva, Moreira, Thereza Maria Magalhães, Souza, Jerffeson Teixeira de, Pereira, Maria Lúcia Duarte
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Rev Rene (Online)
Texto Completo: http://periodicos.ufc.br/rene/article/view/70733
Resumo: Objective: to estimate the prevalence of drug-resistant tuberculosis and associated factors. Methods: a retrospective study that evaluated 74,006 cases of tuberculosis registered in the Notifiable Diseases Information System. In the multivariate analysis, the outcome variable “drug resistance” was used to estimate the prevalence ratio of factors associated with drug resistance. Results: a rate of 0.5% of drug resistance was estimated (n=388). A higher prevalence was observed in cases classified as relapse, post-dropout re-entry, and transfer. There was a 53.0% increase when sputum smear microscopy was positive and a 6.5 increase for positive sputum culture. The opposite effect was observed when the diagnostic test for human immunodeficiency virus was not performed. Conclusion: a low prevalence of drug-resistant tuberculosis was estimated compared to international scenarios. The main factors associated with the disease were related to retreatments and positive sputum smear and culture results.
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spelling Prevalence of drug-resistant tuberculosis and associated factorsPrevalência de tuberculose drogarresistente e fatores associadosTuberculosis; Tuberculosis, Multidrug-Resistant; Nursing; Epidemiology; Public Health.Tuberculose; Tuberculose Resistente a Múltiplos Medicamentos; Enfermagem; Epidemiologia; Saúde Pública.Objective: to estimate the prevalence of drug-resistant tuberculosis and associated factors. Methods: a retrospective study that evaluated 74,006 cases of tuberculosis registered in the Notifiable Diseases Information System. In the multivariate analysis, the outcome variable “drug resistance” was used to estimate the prevalence ratio of factors associated with drug resistance. Results: a rate of 0.5% of drug resistance was estimated (n=388). A higher prevalence was observed in cases classified as relapse, post-dropout re-entry, and transfer. There was a 53.0% increase when sputum smear microscopy was positive and a 6.5 increase for positive sputum culture. The opposite effect was observed when the diagnostic test for human immunodeficiency virus was not performed. Conclusion: a low prevalence of drug-resistant tuberculosis was estimated compared to international scenarios. The main factors associated with the disease were related to retreatments and positive sputum smear and culture results.Objetivo: estimar a prevalência de tuberculose drogarresistente e os fatores a ela associados. Métodos: estudo retrospectivo que avaliou 74.006 casos de tuberculose registrados no Sistema de Informação de Agravos de Notificação. Na análise multivariada, utilizou-se da variável desfecho “resistência medicamentosa” para estimar a razão de prevalência dos fatores associados à drogarresistência. Resultados: estimou-se taxa de 0,5% de drogarresistência (n=388). Observou-se maior prevalência nos casos classificados como recidiva, reingresso pós-abandono e transferência. Houve aumento de 53,0% quando a baciloscopia de escarro foi positiva e de 6,5 vezes para cultura de escarro positiva. Efeito contrário foi observado mediante a não realização do exame diagnóstico para vírus da imunodeficiência humana. Conclusão: estimou-se baixa prevalência de tuberculose drogarresistente comparada a cenários internacionais. Os principais fatores associados à doença estiveram ligados aos retratamentos e ao resultado positivo da baciloscopia e cultura de escarro.Universidade Federal do Ceará2021-08-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://periodicos.ufc.br/rene/article/view/7073310.15253/2175-6783.20212270733Rev Rene; Vol 22 (2021): Rev Rene; e70733Rev Rene; v. 22 (2021): Rev Rene; e707332175-67831517-3852reponame:Rev Rene (Online)instname:Universidade Federal do Ceará (UFC)instacron:UFCporenghttp://periodicos.ufc.br/rene/article/view/70733/197191http://periodicos.ufc.br/rene/article/view/70733/197192Copyright (c) 2021 Rev Renehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSousa, George Jó BezerraMaranhão, Thatiana AraújoLeitão, Terezinha do Menino Jesus SilvaMoreira, Thereza Maria MagalhãesSouza, Jerffeson Teixeira dePereira, Maria Lúcia Duarte2021-08-12T16:33:53Zoai:periodicos.ufc:article/70733Revistahttp://periodicos.ufc.br/renePUBhttp://periodicos.ufc.br/rene/oairene@ufc.br||2175-67831517-3852opendoar:2021-08-12T16:33:53Rev Rene (Online) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Prevalence of drug-resistant tuberculosis and associated factors
Prevalência de tuberculose drogarresistente e fatores associados
title Prevalence of drug-resistant tuberculosis and associated factors
spellingShingle Prevalence of drug-resistant tuberculosis and associated factors
Sousa, George Jó Bezerra
Tuberculosis; Tuberculosis, Multidrug-Resistant; Nursing; Epidemiology; Public Health.
Tuberculose; Tuberculose Resistente a Múltiplos Medicamentos; Enfermagem; Epidemiologia; Saúde Pública.
title_short Prevalence of drug-resistant tuberculosis and associated factors
title_full Prevalence of drug-resistant tuberculosis and associated factors
title_fullStr Prevalence of drug-resistant tuberculosis and associated factors
title_full_unstemmed Prevalence of drug-resistant tuberculosis and associated factors
title_sort Prevalence of drug-resistant tuberculosis and associated factors
author Sousa, George Jó Bezerra
author_facet Sousa, George Jó Bezerra
Maranhão, Thatiana Araújo
Leitão, Terezinha do Menino Jesus Silva
Moreira, Thereza Maria Magalhães
Souza, Jerffeson Teixeira de
Pereira, Maria Lúcia Duarte
author_role author
author2 Maranhão, Thatiana Araújo
Leitão, Terezinha do Menino Jesus Silva
Moreira, Thereza Maria Magalhães
Souza, Jerffeson Teixeira de
Pereira, Maria Lúcia Duarte
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Sousa, George Jó Bezerra
Maranhão, Thatiana Araújo
Leitão, Terezinha do Menino Jesus Silva
Moreira, Thereza Maria Magalhães
Souza, Jerffeson Teixeira de
Pereira, Maria Lúcia Duarte
dc.subject.por.fl_str_mv Tuberculosis; Tuberculosis, Multidrug-Resistant; Nursing; Epidemiology; Public Health.
Tuberculose; Tuberculose Resistente a Múltiplos Medicamentos; Enfermagem; Epidemiologia; Saúde Pública.
topic Tuberculosis; Tuberculosis, Multidrug-Resistant; Nursing; Epidemiology; Public Health.
Tuberculose; Tuberculose Resistente a Múltiplos Medicamentos; Enfermagem; Epidemiologia; Saúde Pública.
description Objective: to estimate the prevalence of drug-resistant tuberculosis and associated factors. Methods: a retrospective study that evaluated 74,006 cases of tuberculosis registered in the Notifiable Diseases Information System. In the multivariate analysis, the outcome variable “drug resistance” was used to estimate the prevalence ratio of factors associated with drug resistance. Results: a rate of 0.5% of drug resistance was estimated (n=388). A higher prevalence was observed in cases classified as relapse, post-dropout re-entry, and transfer. There was a 53.0% increase when sputum smear microscopy was positive and a 6.5 increase for positive sputum culture. The opposite effect was observed when the diagnostic test for human immunodeficiency virus was not performed. Conclusion: a low prevalence of drug-resistant tuberculosis was estimated compared to international scenarios. The main factors associated with the disease were related to retreatments and positive sputum smear and culture results.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://periodicos.ufc.br/rene/article/view/70733
10.15253/2175-6783.20212270733
url http://periodicos.ufc.br/rene/article/view/70733
identifier_str_mv 10.15253/2175-6783.20212270733
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv http://periodicos.ufc.br/rene/article/view/70733/197191
http://periodicos.ufc.br/rene/article/view/70733/197192
dc.rights.driver.fl_str_mv Copyright (c) 2021 Rev Rene
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Rev Rene
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do Ceará
publisher.none.fl_str_mv Universidade Federal do Ceará
dc.source.none.fl_str_mv Rev Rene; Vol 22 (2021): Rev Rene; e70733
Rev Rene; v. 22 (2021): Rev Rene; e70733
2175-6783
1517-3852
reponame:Rev Rene (Online)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Rev Rene (Online)
collection Rev Rene (Online)
repository.name.fl_str_mv Rev Rene (Online) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv rene@ufc.br||
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