Linfopenia como preditor de ventilação mecânica invasiva em pacientes hospitalizados sobreviventes de COVID-19
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Fisioterapia & Saúde Funcional |
Texto Completo: | http://periodicos.ufc.br/fisioterapiaesaudefuncional/article/view/91912 |
Resumo: | ABSTRACT Background: Although most studies describe the role of lymphocytes in COVID-19 severity and mortality, there is still a lack of data in the literature on whether lymphocytes may be good predictors of severity in surviving patients post-hospitalization for COVID-19. Objectives: The aim of this study was to investigate whether the lymphocyte count, measured at hospital admission, could be a potential marker of severity among COVID-19 survivor patients who needed hospitalization, and returned after one month of the discharge. Methods: Prospective observational cohort study of hospitalized unvaccinated adult patients diagnosed with COVID-19. Subjects underwent clinical and laboratory evaluation at the time of admission and after one month of discharge. Results: A total of 44 patients were included, 20 were admitted to the Intensive Care Unit and 10 required invasive mechanical ventilation (IMV). Patients with the lowest lymphocyte count values were predominantly male, had more ageusia symptom, and needed more invasive mechanical ventilation. ROC curve analysis determined that lymphocyte count cutoff values ≤ 971 cell/mm3, area under the curve of 0.77 [CI: 0.61-0.92; p=0.01], sensitivity (80%), and specificity (61%) to identify the need for invasive mechanical ventilation. There was complete recovery of lymphocytes and no unfavorable outcome with a one-month follow-up after hospital discharge. Conclusion: Lymphocyte count ≤971 cells/mm3 had good accuracy in the prediction of the need for invasive mechanical ventilation in surviving patients hospitalized due to COVID-19. |
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Fisioterapia & Saúde Funcional |
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Linfopenia como preditor de ventilação mecânica invasiva em pacientes hospitalizados sobreviventes de COVID-19ABSTRACT Background: Although most studies describe the role of lymphocytes in COVID-19 severity and mortality, there is still a lack of data in the literature on whether lymphocytes may be good predictors of severity in surviving patients post-hospitalization for COVID-19. Objectives: The aim of this study was to investigate whether the lymphocyte count, measured at hospital admission, could be a potential marker of severity among COVID-19 survivor patients who needed hospitalization, and returned after one month of the discharge. Methods: Prospective observational cohort study of hospitalized unvaccinated adult patients diagnosed with COVID-19. Subjects underwent clinical and laboratory evaluation at the time of admission and after one month of discharge. Results: A total of 44 patients were included, 20 were admitted to the Intensive Care Unit and 10 required invasive mechanical ventilation (IMV). Patients with the lowest lymphocyte count values were predominantly male, had more ageusia symptom, and needed more invasive mechanical ventilation. ROC curve analysis determined that lymphocyte count cutoff values ≤ 971 cell/mm3, area under the curve of 0.77 [CI: 0.61-0.92; p=0.01], sensitivity (80%), and specificity (61%) to identify the need for invasive mechanical ventilation. There was complete recovery of lymphocytes and no unfavorable outcome with a one-month follow-up after hospital discharge. Conclusion: Lymphocyte count ≤971 cells/mm3 had good accuracy in the prediction of the need for invasive mechanical ventilation in surviving patients hospitalized due to COVID-19.Fisioterapia & Saúde Funcional2023-10-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://periodicos.ufc.br/fisioterapiaesaudefuncional/article/view/91912Fisioterapia & Saúde Funcional; v. 10 n. 2 (2023): REVISTA FISIOTERAPIA & SAÚDE FUNCIONAL; 1-92238-80280000-0000reponame:Fisioterapia & Saúde Funcionalinstname:Universidade Federal do Ceará (UFC)instacron:UFCporhttp://periodicos.ufc.br/fisioterapiaesaudefuncional/article/view/91912/249874Copyright (c) 2023 Thais Batistella Boteon, Cássia da Luz Goulart, Glieb Slywitch Filho, Iago Júlio Fernandes Nogueira Brito, Érica Letícia Angelo Liberato, João Paulo Gregorio, Alex Rafael de Oliveira, Gustavo Alexandre Cruz, Henrique Pott-Jr, Fabiola Paula Galhardo Rizzatti, Sigrid de Sousa Santos, Daniela Kuguimoto Andaku, Meliza Goi Roscaniinfo:eu-repo/semantics/openAccessBatistella Boteon, Thaisda Luz Goulart, CássiaSlywitch Filho, GliebJúlio Fernandes Nogueira Brito, IagoLetícia Angelo Liberato, ÉricaPaulo Gregorio, JoãoRafael de Oliveira, AlexAlexandre Cruz, GustavoPott-Jr, HenriquePaula Galhardo Rizzatti, Fabiolade Sousa Santos, SigridKuguimoto Andaku, DanielaGoi Roscani, Meliza2023-12-24T19:18:05Zoai:periodicos.ufc:article/91912Revistahttp://periodicos.ufc.br/fisioterapiaesaudefuncional/indexPUBhttp://periodicos.ufc.br/fisioterapiaesaudefuncional/oairenatabessa@ufc.br || fisioterapiaesaudefuncional@gmail.com2238-80282238-8028opendoar:2023-12-24T19:18:05Fisioterapia & Saúde Funcional - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Linfopenia como preditor de ventilação mecânica invasiva em pacientes hospitalizados sobreviventes de COVID-19 |
title |
Linfopenia como preditor de ventilação mecânica invasiva em pacientes hospitalizados sobreviventes de COVID-19 |
spellingShingle |
Linfopenia como preditor de ventilação mecânica invasiva em pacientes hospitalizados sobreviventes de COVID-19 Batistella Boteon, Thais |
title_short |
Linfopenia como preditor de ventilação mecânica invasiva em pacientes hospitalizados sobreviventes de COVID-19 |
title_full |
Linfopenia como preditor de ventilação mecânica invasiva em pacientes hospitalizados sobreviventes de COVID-19 |
title_fullStr |
Linfopenia como preditor de ventilação mecânica invasiva em pacientes hospitalizados sobreviventes de COVID-19 |
title_full_unstemmed |
Linfopenia como preditor de ventilação mecânica invasiva em pacientes hospitalizados sobreviventes de COVID-19 |
title_sort |
Linfopenia como preditor de ventilação mecânica invasiva em pacientes hospitalizados sobreviventes de COVID-19 |
author |
Batistella Boteon, Thais |
author_facet |
Batistella Boteon, Thais da Luz Goulart, Cássia Slywitch Filho, Glieb Júlio Fernandes Nogueira Brito, Iago Letícia Angelo Liberato, Érica Paulo Gregorio, João Rafael de Oliveira, Alex Alexandre Cruz, Gustavo Pott-Jr, Henrique Paula Galhardo Rizzatti, Fabiola de Sousa Santos, Sigrid Kuguimoto Andaku, Daniela Goi Roscani, Meliza |
author_role |
author |
author2 |
da Luz Goulart, Cássia Slywitch Filho, Glieb Júlio Fernandes Nogueira Brito, Iago Letícia Angelo Liberato, Érica Paulo Gregorio, João Rafael de Oliveira, Alex Alexandre Cruz, Gustavo Pott-Jr, Henrique Paula Galhardo Rizzatti, Fabiola de Sousa Santos, Sigrid Kuguimoto Andaku, Daniela Goi Roscani, Meliza |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Batistella Boteon, Thais da Luz Goulart, Cássia Slywitch Filho, Glieb Júlio Fernandes Nogueira Brito, Iago Letícia Angelo Liberato, Érica Paulo Gregorio, João Rafael de Oliveira, Alex Alexandre Cruz, Gustavo Pott-Jr, Henrique Paula Galhardo Rizzatti, Fabiola de Sousa Santos, Sigrid Kuguimoto Andaku, Daniela Goi Roscani, Meliza |
description |
ABSTRACT Background: Although most studies describe the role of lymphocytes in COVID-19 severity and mortality, there is still a lack of data in the literature on whether lymphocytes may be good predictors of severity in surviving patients post-hospitalization for COVID-19. Objectives: The aim of this study was to investigate whether the lymphocyte count, measured at hospital admission, could be a potential marker of severity among COVID-19 survivor patients who needed hospitalization, and returned after one month of the discharge. Methods: Prospective observational cohort study of hospitalized unvaccinated adult patients diagnosed with COVID-19. Subjects underwent clinical and laboratory evaluation at the time of admission and after one month of discharge. Results: A total of 44 patients were included, 20 were admitted to the Intensive Care Unit and 10 required invasive mechanical ventilation (IMV). Patients with the lowest lymphocyte count values were predominantly male, had more ageusia symptom, and needed more invasive mechanical ventilation. ROC curve analysis determined that lymphocyte count cutoff values ≤ 971 cell/mm3, area under the curve of 0.77 [CI: 0.61-0.92; p=0.01], sensitivity (80%), and specificity (61%) to identify the need for invasive mechanical ventilation. There was complete recovery of lymphocytes and no unfavorable outcome with a one-month follow-up after hospital discharge. Conclusion: Lymphocyte count ≤971 cells/mm3 had good accuracy in the prediction of the need for invasive mechanical ventilation in surviving patients hospitalized due to COVID-19. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-10-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://periodicos.ufc.br/fisioterapiaesaudefuncional/article/view/91912 |
url |
http://periodicos.ufc.br/fisioterapiaesaudefuncional/article/view/91912 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
http://periodicos.ufc.br/fisioterapiaesaudefuncional/article/view/91912/249874 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Fisioterapia & Saúde Funcional |
publisher.none.fl_str_mv |
Fisioterapia & Saúde Funcional |
dc.source.none.fl_str_mv |
Fisioterapia & Saúde Funcional; v. 10 n. 2 (2023): REVISTA FISIOTERAPIA & SAÚDE FUNCIONAL; 1-9 2238-8028 0000-0000 reponame:Fisioterapia & Saúde Funcional instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Fisioterapia & Saúde Funcional |
collection |
Fisioterapia & Saúde Funcional |
repository.name.fl_str_mv |
Fisioterapia & Saúde Funcional - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
renatabessa@ufc.br || fisioterapiaesaudefuncional@gmail.com |
_version_ |
1799695360210239488 |