Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Barbosa, Alzira Maria de Castro
Data de Publicação: 2018
Outros Autores: Ribeiro, Rosangela Albuquerque, Silva, Cícero Ígor Simões Moura, Cruz, Francisco Will Saraiva, Azevedo, Orleancio Gomes Ripardo de, Pitombeira, Maria Helena da Silva, Braga, Lucia Libanez Campelo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/35287
Resumo: Background: Several studies have demonstrated that platelet counts in Helicobacter pyloripositive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent. Objective: The purpose of this studywas to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil. Method: H. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment. Results: The prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy.
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spelling Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern BrazilHelicobacter pyloriPúrpura Trombocitopênica IdiopáticaPurpura, Thrombocytopenic, IdiopathicBackground: Several studies have demonstrated that platelet counts in Helicobacter pyloripositive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent. Objective: The purpose of this studywas to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil. Method: H. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment. Results: The prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy.Revista Brasileira de Hematologia e Hemoterapia2018-08-30T15:13:05Z2018-08-30T15:13:05Z2018-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBARBOSA, A. M. C. et al. Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 40, n. 1, p. 12-17, jan./mar. 2018.1806-0870 (Online)1516-8484http://www.repositorio.ufc.br/handle/riufc/35287Barbosa, Alzira Maria de CastroRibeiro, Rosangela AlbuquerqueSilva, Cícero Ígor Simões MouraCruz, Francisco Will SaraivaAzevedo, Orleancio Gomes Ripardo dePitombeira, Maria Helena da SilvaBraga, Lucia Libanez Campeloengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-17T12:15:43Zoai:repositorio.ufc.br:riufc/35287Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:29:31.724793Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
title Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
spellingShingle Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
Barbosa, Alzira Maria de Castro
Helicobacter pylori
Púrpura Trombocitopênica Idiopática
Purpura, Thrombocytopenic, Idiopathic
title_short Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
title_full Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
title_fullStr Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
title_full_unstemmed Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
title_sort Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
author Barbosa, Alzira Maria de Castro
author_facet Barbosa, Alzira Maria de Castro
Ribeiro, Rosangela Albuquerque
Silva, Cícero Ígor Simões Moura
Cruz, Francisco Will Saraiva
Azevedo, Orleancio Gomes Ripardo de
Pitombeira, Maria Helena da Silva
Braga, Lucia Libanez Campelo
author_role author
author2 Ribeiro, Rosangela Albuquerque
Silva, Cícero Ígor Simões Moura
Cruz, Francisco Will Saraiva
Azevedo, Orleancio Gomes Ripardo de
Pitombeira, Maria Helena da Silva
Braga, Lucia Libanez Campelo
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barbosa, Alzira Maria de Castro
Ribeiro, Rosangela Albuquerque
Silva, Cícero Ígor Simões Moura
Cruz, Francisco Will Saraiva
Azevedo, Orleancio Gomes Ripardo de
Pitombeira, Maria Helena da Silva
Braga, Lucia Libanez Campelo
dc.subject.por.fl_str_mv Helicobacter pylori
Púrpura Trombocitopênica Idiopática
Purpura, Thrombocytopenic, Idiopathic
topic Helicobacter pylori
Púrpura Trombocitopênica Idiopática
Purpura, Thrombocytopenic, Idiopathic
description Background: Several studies have demonstrated that platelet counts in Helicobacter pyloripositive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent. Objective: The purpose of this studywas to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil. Method: H. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment. Results: The prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy.
publishDate 2018
dc.date.none.fl_str_mv 2018-08-30T15:13:05Z
2018-08-30T15:13:05Z
2018-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv BARBOSA, A. M. C. et al. Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 40, n. 1, p. 12-17, jan./mar. 2018.
1806-0870 (Online)
1516-8484
http://www.repositorio.ufc.br/handle/riufc/35287
identifier_str_mv BARBOSA, A. M. C. et al. Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 40, n. 1, p. 12-17, jan./mar. 2018.
1806-0870 (Online)
1516-8484
url http://www.repositorio.ufc.br/handle/riufc/35287
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia
publisher.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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