Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/35287 |
Resumo: | Background: Several studies have demonstrated that platelet counts in Helicobacter pyloripositive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent. Objective: The purpose of this studywas to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil. Method: H. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment. Results: The prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy. |
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Repositório Institucional da Universidade Federal do Ceará (UFC) |
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Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern BrazilHelicobacter pyloriPúrpura Trombocitopênica IdiopáticaPurpura, Thrombocytopenic, IdiopathicBackground: Several studies have demonstrated that platelet counts in Helicobacter pyloripositive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent. Objective: The purpose of this studywas to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil. Method: H. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment. Results: The prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy.Revista Brasileira de Hematologia e Hemoterapia2018-08-30T15:13:05Z2018-08-30T15:13:05Z2018-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBARBOSA, A. M. C. et al. Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 40, n. 1, p. 12-17, jan./mar. 2018.1806-0870 (Online)1516-8484http://www.repositorio.ufc.br/handle/riufc/35287Barbosa, Alzira Maria de CastroRibeiro, Rosangela AlbuquerqueSilva, Cícero Ígor Simões MouraCruz, Francisco Will SaraivaAzevedo, Orleancio Gomes Ripardo dePitombeira, Maria Helena da SilvaBraga, Lucia Libanez Campeloengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-17T12:15:43Zoai:repositorio.ufc.br:riufc/35287Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:29:31.724793Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
title |
Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
spellingShingle |
Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil Barbosa, Alzira Maria de Castro Helicobacter pylori Púrpura Trombocitopênica Idiopática Purpura, Thrombocytopenic, Idiopathic |
title_short |
Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
title_full |
Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
title_fullStr |
Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
title_full_unstemmed |
Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
title_sort |
Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
author |
Barbosa, Alzira Maria de Castro |
author_facet |
Barbosa, Alzira Maria de Castro Ribeiro, Rosangela Albuquerque Silva, Cícero Ígor Simões Moura Cruz, Francisco Will Saraiva Azevedo, Orleancio Gomes Ripardo de Pitombeira, Maria Helena da Silva Braga, Lucia Libanez Campelo |
author_role |
author |
author2 |
Ribeiro, Rosangela Albuquerque Silva, Cícero Ígor Simões Moura Cruz, Francisco Will Saraiva Azevedo, Orleancio Gomes Ripardo de Pitombeira, Maria Helena da Silva Braga, Lucia Libanez Campelo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Barbosa, Alzira Maria de Castro Ribeiro, Rosangela Albuquerque Silva, Cícero Ígor Simões Moura Cruz, Francisco Will Saraiva Azevedo, Orleancio Gomes Ripardo de Pitombeira, Maria Helena da Silva Braga, Lucia Libanez Campelo |
dc.subject.por.fl_str_mv |
Helicobacter pylori Púrpura Trombocitopênica Idiopática Purpura, Thrombocytopenic, Idiopathic |
topic |
Helicobacter pylori Púrpura Trombocitopênica Idiopática Purpura, Thrombocytopenic, Idiopathic |
description |
Background: Several studies have demonstrated that platelet counts in Helicobacter pyloripositive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent. Objective: The purpose of this studywas to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil. Method: H. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment. Results: The prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-08-30T15:13:05Z 2018-08-30T15:13:05Z 2018-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
BARBOSA, A. M. C. et al. Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 40, n. 1, p. 12-17, jan./mar. 2018. 1806-0870 (Online) 1516-8484 http://www.repositorio.ufc.br/handle/riufc/35287 |
identifier_str_mv |
BARBOSA, A. M. C. et al. Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 40, n. 1, p. 12-17, jan./mar. 2018. 1806-0870 (Online) 1516-8484 |
url |
http://www.repositorio.ufc.br/handle/riufc/35287 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia |
publisher.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
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1813028826646577152 |