Avaliação farmacológica da Detomidina no trato reprodutivo de éguas (Equus caballus)

• Autor(a) principal: Evangelista, João José Ferreira
• Data de Publicação: 2015
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
• Texto Completo: http://www.repositorio.ufc.br/handle/riufc/15379
• topic: Útero; Ultrassonografia Doppler

The Detomidine is an agonist of α2-adrenergic receptors, derived imidazole alkaloid, available on the hydrochloride formula, is related to selectivity between receptor α2/α1 of 260/1. The experiment was conducted to investigate the interference of detomidine on equine reproductive tract. Twenty-five mares were used mongrel, not pregnant, aged between 4-10 years old and weighing 350-450kg. The 25 mares were divided randomly into 5 groups, with 3 groups were submitted at doses of the detomidineof 6, 9 and 12μg/kg,respectively. In the other two groups, one applied yohimbine dose of 0.10 mg/kg 20 minutes prior to the application of 6μg/kg detomidine and in control group. All they were made sonographic evaluations in B mode and Doppler of the reproductive tract of mares. The pulsatility index (PI), resistance index (RI) and uterine blood right wrist (UBRW) and the subjective evaluation of the uterus and mesometriumblood supply, showed no significant difference (P<0.05) when compared to animals treated with detomidine 6μg/kg compared to the same dose applied, but had blocked by yohimbine of 10mg/kg. The doses of detomidine in the 6, 9 and 12μg/kg interfered with the dynamics of the uterine cervix, providing temporary expansion, with significant differences in maximum magnitude of the response time, 2.1 ± 0,11mm (P>0.0001) to 5 minutes, 2.7 ± 0.26 (P>0.0001) after 10 minutes and 4.9 ± 0.18 mm (P>0.0001) after 15 minutes, respectively. In epidural detomidinedose of 6μg/kg,comparing the cervical dilatation, occurred with the same dose in the IV route showed a significant difference in 5 (P>0.0001), 15 (P>0.0001), 20 (P>0.0001) and 25 (P>0.0001) minutes. When the use of detomidine in cervical response withthe intramuscularlydose of 6μg/kg comparing to RI, there was a significant difference in 5 (P<0.0001), 15 (P>0.0001), 20 (P>0.0001) and 25 (P>0.0001) minutes. We concluded that, the detomidinedoses of 6 (intravenous, intramuscular and epidural), 9 and 12µg/kg (intravenous) promoted temporary cervical dilation in mares.