Mycoleptones A−C and polyketides from the endophytem mycoleptodiscus indicus

• Autor(a) principal: Andrioli, Willian J.
• Data de Publicação: 2014
• Outros Autores: Conti, Raphael, Araújo, Magali J., Zanasi, Riccardo, Cavalcanti, Bruno C., Manfrim, Viviane, Toledo, Juliano S., Tedesco, Daniele, Moraes Filho, Manoel Odorico de, Pessoa, Cláudia, Cruz, Angela K., Bertucci, Carlo, Sabino, José, Nanayakkara, Dhammika N. P., Bastos, Jairo K.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
• Texto Completo: http://www.repositorio.ufc.br/handle/riufc/7214
• topic: Cristalografia; Citotoxicidade Imunológica

Three new azaphilones with an unusual methylene bridge, named mycoleptones A, B, and C (2, 4, and 5), were isolated from cultures of Mycoleptodiscus indicus, a fungus associated with the South American medicinal plant Borreria verticillata. Additionally, four known polyketides, austdiol (1), eugenitin (3), 6-methoxyeugenin (6), and 9- hydroxyeugenin (7), were also isolated. The structural characterization of compounds was carried out by nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, electronic circular dichroism spectroscopy, timedependent density functional theory calculations, and X-ray crystallography. Compounds 1−9 were weakly active when tested in antileishmanial and cytotoxicity assays.