Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents

Detalhes bibliográficos
Autor(a) principal: Araújo, Joana Cláudia Bezerra de
Data de Publicação: 2017
Outros Autores: Gondim, Delane Viana, Cavalcante, André Luiz Cunha, Lisboa, Mario Roberto Pontes, Brito, Gerly Anne de Castro, Vale, Mariana Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/26347
Resumo: ARAÚJO, Joana Cláudia Bezerra de et al. Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents. Journal of Pharmacological and Toxicological Methods, New York, v. 88, p. 100-108, nov. 2017.
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spelling Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agentsEspectroscopia de Ressonância MagnéticaMagnetic Resonance SpectroscopyGranuloma PeriapicalArtriteARAÚJO, Joana Cláudia Bezerra de et al. Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents. Journal of Pharmacological and Toxicological Methods, New York, v. 88, p. 100-108, nov. 2017.Temporomandibular joint (TMJ) disorders are a group of conditions that result in TMJ pain, which frequently limits basic daily activities. Experimental models that allow the study of the mechanisms underlying these inflammatory and pain conditions are of great clinical relevance. The aim of this study was to evaluate nociception, inflammation and participation of the macrophage/microglia cells in the arthritis of the TMJ induced by two phlogistic agents. 84 rats were divided into 2 groups: Zy, which received zymosan intra-articularly, or Cg, which received carrageenan intra-articularly. Mechanical nociception, total leukocyte influx to the synovial fluid and histopathological analyses were evaluated in the TMJ. The participation of macrophage/microglia located in trigeminal ganglia (TG) and in the subnucleus caudalis (V-SnC) was assessed immunohistochemically. Both agents induced mechanical hyperalgesia 6 h after the induction, but a more persistent algesic state was perceived in the Cg group, which lasted for 120 h. Even though both groups presented increased leukocyte influx, the Zy-group presented a more intense influx. Zymosan recruited resident macrophage in the trigeminal ganglia 24 h after the injection. In the V-SnC, the group Cg presented a more prolonged immunolabeling pattern in comparison with the group Zy. It can be concluded that zymosan induced a more intense infiltrate and peripheral nervous changes, while Cg lead to a moderate TMJ inflammation with prominent changes in the V-SnC.Journal of Pharmacological and Toxicological Methods2017-10-04T18:08:34Z2017-10-04T18:08:34Z2017-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfARAÚJO, J. C. B. et al. Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents. Journal of Pharmacological and Toxicological Methods, New York, v. 88, p. 100-108, nov. 2017.1056-8719http://www.repositorio.ufc.br/handle/riufc/26347Araújo, Joana Cláudia Bezerra deGondim, Delane VianaCavalcante, André Luiz CunhaLisboa, Mario Roberto PontesBrito, Gerly Anne de CastroVale, Mariana Limaengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2018-12-14T13:34:00Zoai:repositorio.ufc.br:riufc/26347Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:24:41.003739Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents
title Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents
spellingShingle Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents
Araújo, Joana Cláudia Bezerra de
Espectroscopia de Ressonância Magnética
Magnetic Resonance Spectroscopy
Granuloma Periapical
Artrite
title_short Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents
title_full Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents
title_fullStr Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents
title_full_unstemmed Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents
title_sort Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents
author Araújo, Joana Cláudia Bezerra de
author_facet Araújo, Joana Cláudia Bezerra de
Gondim, Delane Viana
Cavalcante, André Luiz Cunha
Lisboa, Mario Roberto Pontes
Brito, Gerly Anne de Castro
Vale, Mariana Lima
author_role author
author2 Gondim, Delane Viana
Cavalcante, André Luiz Cunha
Lisboa, Mario Roberto Pontes
Brito, Gerly Anne de Castro
Vale, Mariana Lima
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Araújo, Joana Cláudia Bezerra de
Gondim, Delane Viana
Cavalcante, André Luiz Cunha
Lisboa, Mario Roberto Pontes
Brito, Gerly Anne de Castro
Vale, Mariana Lima
dc.subject.por.fl_str_mv Espectroscopia de Ressonância Magnética
Magnetic Resonance Spectroscopy
Granuloma Periapical
Artrite
topic Espectroscopia de Ressonância Magnética
Magnetic Resonance Spectroscopy
Granuloma Periapical
Artrite
description ARAÚJO, Joana Cláudia Bezerra de et al. Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents. Journal of Pharmacological and Toxicological Methods, New York, v. 88, p. 100-108, nov. 2017.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-04T18:08:34Z
2017-10-04T18:08:34Z
2017-11
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv ARAÚJO, J. C. B. et al. Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents. Journal of Pharmacological and Toxicological Methods, New York, v. 88, p. 100-108, nov. 2017.
1056-8719
http://www.repositorio.ufc.br/handle/riufc/26347
identifier_str_mv ARAÚJO, J. C. B. et al. Inflammatory pain assessment in the arthritis of the temporomandibular joint in rats: a comparison between two phlogistic agents. Journal of Pharmacological and Toxicological Methods, New York, v. 88, p. 100-108, nov. 2017.
1056-8719
url http://www.repositorio.ufc.br/handle/riufc/26347
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal of Pharmacological and Toxicological Methods
publisher.none.fl_str_mv Journal of Pharmacological and Toxicological Methods
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1813028792624480256

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