Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus

Detalhes bibliográficos
Autor(a) principal: Batista, Andressa H. M.
Data de Publicação: 2017
Outros Autores: Moreira, Anne C. D., Carvalho, Rafael M. de, Sales, Gleilton W. P., Nogueira, Patrícia C. N., Grangeiro, Thalles Barbosa, Medeiros, Suelen C., Silveira, Edilberto R., Nogueira, Nádia A. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/26558
Resumo: Violacein is an indole compound, produced by Chromobacterium violaceum, a bacteria present in tropical and subtropical areas. Among its numerous biological activities, its antimicrobial potential stands out. This study aims to determine the antimicrobial activity of VIO on S. aureus in planktonic culture and biofilms. VIO showed excellent antimicrobial activity in inhibiting and killing S. aureus in planktonic cultures and biofilm formation. The minimum bactericidal concentration (5 g/mL) of VIO caused the death of S. aureus after 3–4 h of exposure and the minimum inhibitory concentration (1.25 g/mL) of VIO inhibited bacterial growth within the first 8 h of contact. Biofilm formation was also strongly inhibited by VIO (1.25 g/mL), in contrast to the higher resistance verified for S. aureus in mature biofilm (40 g/mL). The high bacterial metabolic activity favored VIO activity; however, the good activity observed during phases of reduced metabolism indicates that VIO action involves more than one mechanism. Thus, VIO is a promising molecule for the development of an antimicrobial drug for the eradication of S. aureus infections.
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spelling Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureusBiofilmesBiofilmsStaphylococcus aureusViolacein is an indole compound, produced by Chromobacterium violaceum, a bacteria present in tropical and subtropical areas. Among its numerous biological activities, its antimicrobial potential stands out. This study aims to determine the antimicrobial activity of VIO on S. aureus in planktonic culture and biofilms. VIO showed excellent antimicrobial activity in inhibiting and killing S. aureus in planktonic cultures and biofilm formation. The minimum bactericidal concentration (5 g/mL) of VIO caused the death of S. aureus after 3–4 h of exposure and the minimum inhibitory concentration (1.25 g/mL) of VIO inhibited bacterial growth within the first 8 h of contact. Biofilm formation was also strongly inhibited by VIO (1.25 g/mL), in contrast to the higher resistance verified for S. aureus in mature biofilm (40 g/mL). The high bacterial metabolic activity favored VIO activity; however, the good activity observed during phases of reduced metabolism indicates that VIO action involves more than one mechanism. Thus, VIO is a promising molecule for the development of an antimicrobial drug for the eradication of S. aureus infections.Molecules2017-10-10T17:55:12Z2017-10-10T17:55:12Z2017-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBATISTA, A. H. M. et al. Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus. Molecules, Basel, v. 22, n.10, p. 1-10, sep. 2017.1420-3049http://www.repositorio.ufc.br/handle/riufc/26558Batista, Andressa H. M.Moreira, Anne C. D.Carvalho, Rafael M. deSales, Gleilton W. P.Nogueira, Patrícia C. N.Grangeiro, Thalles BarbosaMedeiros, Suelen C.Silveira, Edilberto R.Nogueira, Nádia A. P.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-12-11T01:34:35Zoai:repositorio.ufc.br:riufc/26558Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:30:27.571197Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus
title Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus
spellingShingle Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus
Batista, Andressa H. M.
Biofilmes
Biofilms
Staphylococcus aureus
title_short Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus
title_full Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus
title_fullStr Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus
title_full_unstemmed Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus
title_sort Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus
author Batista, Andressa H. M.
author_facet Batista, Andressa H. M.
Moreira, Anne C. D.
Carvalho, Rafael M. de
Sales, Gleilton W. P.
Nogueira, Patrícia C. N.
Grangeiro, Thalles Barbosa
Medeiros, Suelen C.
Silveira, Edilberto R.
Nogueira, Nádia A. P.
author_role author
author2 Moreira, Anne C. D.
Carvalho, Rafael M. de
Sales, Gleilton W. P.
Nogueira, Patrícia C. N.
Grangeiro, Thalles Barbosa
Medeiros, Suelen C.
Silveira, Edilberto R.
Nogueira, Nádia A. P.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Batista, Andressa H. M.
Moreira, Anne C. D.
Carvalho, Rafael M. de
Sales, Gleilton W. P.
Nogueira, Patrícia C. N.
Grangeiro, Thalles Barbosa
Medeiros, Suelen C.
Silveira, Edilberto R.
Nogueira, Nádia A. P.
dc.subject.por.fl_str_mv Biofilmes
Biofilms
Staphylococcus aureus
topic Biofilmes
Biofilms
Staphylococcus aureus
description Violacein is an indole compound, produced by Chromobacterium violaceum, a bacteria present in tropical and subtropical areas. Among its numerous biological activities, its antimicrobial potential stands out. This study aims to determine the antimicrobial activity of VIO on S. aureus in planktonic culture and biofilms. VIO showed excellent antimicrobial activity in inhibiting and killing S. aureus in planktonic cultures and biofilm formation. The minimum bactericidal concentration (5 g/mL) of VIO caused the death of S. aureus after 3–4 h of exposure and the minimum inhibitory concentration (1.25 g/mL) of VIO inhibited bacterial growth within the first 8 h of contact. Biofilm formation was also strongly inhibited by VIO (1.25 g/mL), in contrast to the higher resistance verified for S. aureus in mature biofilm (40 g/mL). The high bacterial metabolic activity favored VIO activity; however, the good activity observed during phases of reduced metabolism indicates that VIO action involves more than one mechanism. Thus, VIO is a promising molecule for the development of an antimicrobial drug for the eradication of S. aureus infections.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-10T17:55:12Z
2017-10-10T17:55:12Z
2017-09
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv BATISTA, A. H. M. et al. Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus. Molecules, Basel, v. 22, n.10, p. 1-10, sep. 2017.
1420-3049
http://www.repositorio.ufc.br/handle/riufc/26558
identifier_str_mv BATISTA, A. H. M. et al. Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus. Molecules, Basel, v. 22, n.10, p. 1-10, sep. 2017.
1420-3049
url http://www.repositorio.ufc.br/handle/riufc/26558
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Molecules
publisher.none.fl_str_mv Molecules
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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