Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/26558 |
Resumo: | Violacein is an indole compound, produced by Chromobacterium violaceum, a bacteria present in tropical and subtropical areas. Among its numerous biological activities, its antimicrobial potential stands out. This study aims to determine the antimicrobial activity of VIO on S. aureus in planktonic culture and biofilms. VIO showed excellent antimicrobial activity in inhibiting and killing S. aureus in planktonic cultures and biofilm formation. The minimum bactericidal concentration (5 g/mL) of VIO caused the death of S. aureus after 3–4 h of exposure and the minimum inhibitory concentration (1.25 g/mL) of VIO inhibited bacterial growth within the first 8 h of contact. Biofilm formation was also strongly inhibited by VIO (1.25 g/mL), in contrast to the higher resistance verified for S. aureus in mature biofilm (40 g/mL). The high bacterial metabolic activity favored VIO activity; however, the good activity observed during phases of reduced metabolism indicates that VIO action involves more than one mechanism. Thus, VIO is a promising molecule for the development of an antimicrobial drug for the eradication of S. aureus infections. |
id |
UFC-7_21bc1c9c61c068e22475536ab642ca1d |
---|---|
oai_identifier_str |
oai:repositorio.ufc.br:riufc/26558 |
network_acronym_str |
UFC-7 |
network_name_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository_id_str |
|
spelling |
Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureusBiofilmesBiofilmsStaphylococcus aureusViolacein is an indole compound, produced by Chromobacterium violaceum, a bacteria present in tropical and subtropical areas. Among its numerous biological activities, its antimicrobial potential stands out. This study aims to determine the antimicrobial activity of VIO on S. aureus in planktonic culture and biofilms. VIO showed excellent antimicrobial activity in inhibiting and killing S. aureus in planktonic cultures and biofilm formation. The minimum bactericidal concentration (5 g/mL) of VIO caused the death of S. aureus after 3–4 h of exposure and the minimum inhibitory concentration (1.25 g/mL) of VIO inhibited bacterial growth within the first 8 h of contact. Biofilm formation was also strongly inhibited by VIO (1.25 g/mL), in contrast to the higher resistance verified for S. aureus in mature biofilm (40 g/mL). The high bacterial metabolic activity favored VIO activity; however, the good activity observed during phases of reduced metabolism indicates that VIO action involves more than one mechanism. Thus, VIO is a promising molecule for the development of an antimicrobial drug for the eradication of S. aureus infections.Molecules2017-10-10T17:55:12Z2017-10-10T17:55:12Z2017-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBATISTA, A. H. M. et al. Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus. Molecules, Basel, v. 22, n.10, p. 1-10, sep. 2017.1420-3049http://www.repositorio.ufc.br/handle/riufc/26558Batista, Andressa H. M.Moreira, Anne C. D.Carvalho, Rafael M. deSales, Gleilton W. P.Nogueira, Patrícia C. N.Grangeiro, Thalles BarbosaMedeiros, Suelen C.Silveira, Edilberto R.Nogueira, Nádia A. P.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-12-11T01:34:35Zoai:repositorio.ufc.br:riufc/26558Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:30:27.571197Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus |
title |
Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus |
spellingShingle |
Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus Batista, Andressa H. M. Biofilmes Biofilms Staphylococcus aureus |
title_short |
Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus |
title_full |
Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus |
title_fullStr |
Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus |
title_full_unstemmed |
Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus |
title_sort |
Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus |
author |
Batista, Andressa H. M. |
author_facet |
Batista, Andressa H. M. Moreira, Anne C. D. Carvalho, Rafael M. de Sales, Gleilton W. P. Nogueira, Patrícia C. N. Grangeiro, Thalles Barbosa Medeiros, Suelen C. Silveira, Edilberto R. Nogueira, Nádia A. P. |
author_role |
author |
author2 |
Moreira, Anne C. D. Carvalho, Rafael M. de Sales, Gleilton W. P. Nogueira, Patrícia C. N. Grangeiro, Thalles Barbosa Medeiros, Suelen C. Silveira, Edilberto R. Nogueira, Nádia A. P. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Batista, Andressa H. M. Moreira, Anne C. D. Carvalho, Rafael M. de Sales, Gleilton W. P. Nogueira, Patrícia C. N. Grangeiro, Thalles Barbosa Medeiros, Suelen C. Silveira, Edilberto R. Nogueira, Nádia A. P. |
dc.subject.por.fl_str_mv |
Biofilmes Biofilms Staphylococcus aureus |
topic |
Biofilmes Biofilms Staphylococcus aureus |
description |
Violacein is an indole compound, produced by Chromobacterium violaceum, a bacteria present in tropical and subtropical areas. Among its numerous biological activities, its antimicrobial potential stands out. This study aims to determine the antimicrobial activity of VIO on S. aureus in planktonic culture and biofilms. VIO showed excellent antimicrobial activity in inhibiting and killing S. aureus in planktonic cultures and biofilm formation. The minimum bactericidal concentration (5 g/mL) of VIO caused the death of S. aureus after 3–4 h of exposure and the minimum inhibitory concentration (1.25 g/mL) of VIO inhibited bacterial growth within the first 8 h of contact. Biofilm formation was also strongly inhibited by VIO (1.25 g/mL), in contrast to the higher resistance verified for S. aureus in mature biofilm (40 g/mL). The high bacterial metabolic activity favored VIO activity; however, the good activity observed during phases of reduced metabolism indicates that VIO action involves more than one mechanism. Thus, VIO is a promising molecule for the development of an antimicrobial drug for the eradication of S. aureus infections. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-10T17:55:12Z 2017-10-10T17:55:12Z 2017-09 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
BATISTA, A. H. M. et al. Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus. Molecules, Basel, v. 22, n.10, p. 1-10, sep. 2017. 1420-3049 http://www.repositorio.ufc.br/handle/riufc/26558 |
identifier_str_mv |
BATISTA, A. H. M. et al. Antimicrobial effects of violacein against planktonic cells and biofilms of Staphylococcus aureus. Molecules, Basel, v. 22, n.10, p. 1-10, sep. 2017. 1420-3049 |
url |
http://www.repositorio.ufc.br/handle/riufc/26558 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Molecules |
publisher.none.fl_str_mv |
Molecules |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1813028833257848832 |