A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/59822 |
Resumo: | : Regular exercise is an exogenous factor of gene regulation with numerous health benefits. The study aimed to evaluate human genes linked to physical exercise in an ‘omic scale, addressing biological questions to the generated database. Three literature databases were searched with the terms ‘exercise’, ‘fitness’, ‘physical activity’, ‘genetics’ and ‘gene expression’. For additional references, papers were scrutinized and a textmining tool was used. Papers linking genes to exercise in humans through microarray, RNA-Seq, RT-PCR and genotyping studies were included. Genes were extracted from the collected literature, together with information on exercise protocol, experimental design, gender, age, number of individuals, analytical method, fold change and statistical data. The ‘omic scale dataset was characterized and evaluated with bioinformatics tools searching for gene expression patterns, functional meaning and gene clusters. As a result, a physical exercise-related human gene compendium was created, with data from 58 scientific papers and 5.147 genes functionally correlated with 17 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. While 50.9% of the gene set was up-regulated, 41.9% was down-regulated. 743 up- and 530 down-regulated clusters were found, some connected by regulatory networks. To summarize, up- and down-regulation was encountered, with a wide genomic distribution of the gene set and up- and down-regulated clusters possibly assembled by functional gene evolution. Physical exercise elicits a widespread response in gene expression. |
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A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale AnalysiA Compendium of Physical Exercise-related Human Genes: An'OMIC Scale AnalysiOntologia genética do exercícioGenômica do exercícioGenes ligados ao exercício físicoFisiologia do exercício molecularTranscriptoma de exercício físico: Regular exercise is an exogenous factor of gene regulation with numerous health benefits. The study aimed to evaluate human genes linked to physical exercise in an ‘omic scale, addressing biological questions to the generated database. Three literature databases were searched with the terms ‘exercise’, ‘fitness’, ‘physical activity’, ‘genetics’ and ‘gene expression’. For additional references, papers were scrutinized and a textmining tool was used. Papers linking genes to exercise in humans through microarray, RNA-Seq, RT-PCR and genotyping studies were included. Genes were extracted from the collected literature, together with information on exercise protocol, experimental design, gender, age, number of individuals, analytical method, fold change and statistical data. The ‘omic scale dataset was characterized and evaluated with bioinformatics tools searching for gene expression patterns, functional meaning and gene clusters. As a result, a physical exercise-related human gene compendium was created, with data from 58 scientific papers and 5.147 genes functionally correlated with 17 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. While 50.9% of the gene set was up-regulated, 41.9% was down-regulated. 743 up- and 530 down-regulated clusters were found, some connected by regulatory networks. To summarize, up- and down-regulation was encountered, with a wide genomic distribution of the gene set and up- and down-regulated clusters possibly assembled by functional gene evolution. Physical exercise elicits a widespread response in gene expression.BIOLOGY OF SPORT2021-08-02T22:08:38Z2021-08-02T22:08:38Z2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPACHECO, Christina et al. A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi, BIOLOGY OF SPORT, [s. l.], v.35, p.1-11, 2018http://www.repositorio.ufc.br/handle/riufc/59822Pacheco, ChristinaFelipe, Stela Mirla da SilvaSoares, Milca Magalhães Dias de CarvalhoAlves, Juliana OsórioSoares, Paula MatiasLeal-Cardoso, José HenriqueLoureiro, Adriano César CarneiroFerraz, Alex Soares MarreirosCarvalho, Denise Pires deCeccatto, Vânia Marilandeengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2021-08-02T22:11:20Zoai:repositorio.ufc.br:riufc/59822Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:27:43.362072Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi |
title |
A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi |
spellingShingle |
A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi Pacheco, Christina Ontologia genética do exercício Genômica do exercício Genes ligados ao exercício físico Fisiologia do exercício molecular Transcriptoma de exercício físico |
title_short |
A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi |
title_full |
A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi |
title_fullStr |
A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi |
title_full_unstemmed |
A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi |
title_sort |
A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi |
author |
Pacheco, Christina |
author_facet |
Pacheco, Christina Felipe, Stela Mirla da Silva Soares, Milca Magalhães Dias de Carvalho Alves, Juliana Osório Soares, Paula Matias Leal-Cardoso, José Henrique Loureiro, Adriano César Carneiro Ferraz, Alex Soares Marreiros Carvalho, Denise Pires de Ceccatto, Vânia Marilande |
author_role |
author |
author2 |
Felipe, Stela Mirla da Silva Soares, Milca Magalhães Dias de Carvalho Alves, Juliana Osório Soares, Paula Matias Leal-Cardoso, José Henrique Loureiro, Adriano César Carneiro Ferraz, Alex Soares Marreiros Carvalho, Denise Pires de Ceccatto, Vânia Marilande |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pacheco, Christina Felipe, Stela Mirla da Silva Soares, Milca Magalhães Dias de Carvalho Alves, Juliana Osório Soares, Paula Matias Leal-Cardoso, José Henrique Loureiro, Adriano César Carneiro Ferraz, Alex Soares Marreiros Carvalho, Denise Pires de Ceccatto, Vânia Marilande |
dc.subject.por.fl_str_mv |
Ontologia genética do exercício Genômica do exercício Genes ligados ao exercício físico Fisiologia do exercício molecular Transcriptoma de exercício físico |
topic |
Ontologia genética do exercício Genômica do exercício Genes ligados ao exercício físico Fisiologia do exercício molecular Transcriptoma de exercício físico |
description |
: Regular exercise is an exogenous factor of gene regulation with numerous health benefits. The study aimed to evaluate human genes linked to physical exercise in an ‘omic scale, addressing biological questions to the generated database. Three literature databases were searched with the terms ‘exercise’, ‘fitness’, ‘physical activity’, ‘genetics’ and ‘gene expression’. For additional references, papers were scrutinized and a textmining tool was used. Papers linking genes to exercise in humans through microarray, RNA-Seq, RT-PCR and genotyping studies were included. Genes were extracted from the collected literature, together with information on exercise protocol, experimental design, gender, age, number of individuals, analytical method, fold change and statistical data. The ‘omic scale dataset was characterized and evaluated with bioinformatics tools searching for gene expression patterns, functional meaning and gene clusters. As a result, a physical exercise-related human gene compendium was created, with data from 58 scientific papers and 5.147 genes functionally correlated with 17 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. While 50.9% of the gene set was up-regulated, 41.9% was down-regulated. 743 up- and 530 down-regulated clusters were found, some connected by regulatory networks. To summarize, up- and down-regulation was encountered, with a wide genomic distribution of the gene set and up- and down-regulated clusters possibly assembled by functional gene evolution. Physical exercise elicits a widespread response in gene expression. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2021-08-02T22:08:38Z 2021-08-02T22:08:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
PACHECO, Christina et al. A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi, BIOLOGY OF SPORT, [s. l.], v.35, p.1-11, 2018 http://www.repositorio.ufc.br/handle/riufc/59822 |
identifier_str_mv |
PACHECO, Christina et al. A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi, BIOLOGY OF SPORT, [s. l.], v.35, p.1-11, 2018 |
url |
http://www.repositorio.ufc.br/handle/riufc/59822 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BIOLOGY OF SPORT |
publisher.none.fl_str_mv |
BIOLOGY OF SPORT |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1813028813461782528 |