A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi

Detalhes bibliográficos
Autor(a) principal: Pacheco, Christina
Data de Publicação: 2018
Outros Autores: Felipe, Stela Mirla da Silva, Soares, Milca Magalhães Dias de Carvalho, Alves, Juliana Osório, Soares, Paula Matias, Leal-Cardoso, José Henrique, Loureiro, Adriano César Carneiro, Ferraz, Alex Soares Marreiros, Carvalho, Denise Pires de, Ceccatto, Vânia Marilande
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/59822
Resumo: : Regular exercise is an exogenous factor of gene regulation with numerous health benefits. The study aimed to evaluate human genes linked to physical exercise in an ‘omic scale, addressing biological questions to the generated database. Three literature databases were searched with the terms ‘exercise’, ‘fitness’, ‘physical activity’, ‘genetics’ and ‘gene expression’. For additional references, papers were scrutinized and a textmining tool was used. Papers linking genes to exercise in humans through microarray, RNA-Seq, RT-PCR and genotyping studies were included. Genes were extracted from the collected literature, together with information on exercise protocol, experimental design, gender, age, number of individuals, analytical method, fold change and statistical data. The ‘omic scale dataset was characterized and evaluated with bioinformatics tools searching for gene expression patterns, functional meaning and gene clusters. As a result, a physical exercise-related human gene compendium was created, with data from 58 scientific papers and 5.147 genes functionally correlated with 17 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. While 50.9% of the gene set was up-regulated, 41.9% was down-regulated. 743 up- and 530 down-regulated clusters were found, some connected by regulatory networks. To summarize, up- and down-regulation was encountered, with a wide genomic distribution of the gene set and up- and down-regulated clusters possibly assembled by functional gene evolution. Physical exercise elicits a widespread response in gene expression.
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spelling A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale AnalysiA Compendium of Physical Exercise-related Human Genes: An'OMIC Scale AnalysiOntologia genética do exercícioGenômica do exercícioGenes ligados ao exercício físicoFisiologia do exercício molecularTranscriptoma de exercício físico: Regular exercise is an exogenous factor of gene regulation with numerous health benefits. The study aimed to evaluate human genes linked to physical exercise in an ‘omic scale, addressing biological questions to the generated database. Three literature databases were searched with the terms ‘exercise’, ‘fitness’, ‘physical activity’, ‘genetics’ and ‘gene expression’. For additional references, papers were scrutinized and a textmining tool was used. Papers linking genes to exercise in humans through microarray, RNA-Seq, RT-PCR and genotyping studies were included. Genes were extracted from the collected literature, together with information on exercise protocol, experimental design, gender, age, number of individuals, analytical method, fold change and statistical data. The ‘omic scale dataset was characterized and evaluated with bioinformatics tools searching for gene expression patterns, functional meaning and gene clusters. As a result, a physical exercise-related human gene compendium was created, with data from 58 scientific papers and 5.147 genes functionally correlated with 17 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. While 50.9% of the gene set was up-regulated, 41.9% was down-regulated. 743 up- and 530 down-regulated clusters were found, some connected by regulatory networks. To summarize, up- and down-regulation was encountered, with a wide genomic distribution of the gene set and up- and down-regulated clusters possibly assembled by functional gene evolution. Physical exercise elicits a widespread response in gene expression.BIOLOGY OF SPORT2021-08-02T22:08:38Z2021-08-02T22:08:38Z2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPACHECO, Christina et al. A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi, BIOLOGY OF SPORT, [s. l.], v.35, p.1-11, 2018http://www.repositorio.ufc.br/handle/riufc/59822Pacheco, ChristinaFelipe, Stela Mirla da SilvaSoares, Milca Magalhães Dias de CarvalhoAlves, Juliana OsórioSoares, Paula MatiasLeal-Cardoso, José HenriqueLoureiro, Adriano César CarneiroFerraz, Alex Soares MarreirosCarvalho, Denise Pires deCeccatto, Vânia Marilandeengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2021-08-02T22:11:20Zoai:repositorio.ufc.br:riufc/59822Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:27:43.362072Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi
A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi
title A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi
spellingShingle A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi
Pacheco, Christina
Ontologia genética do exercício
Genômica do exercício
Genes ligados ao exercício físico
Fisiologia do exercício molecular
Transcriptoma de exercício físico
title_short A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi
title_full A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi
title_fullStr A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi
title_full_unstemmed A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi
title_sort A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi
author Pacheco, Christina
author_facet Pacheco, Christina
Felipe, Stela Mirla da Silva
Soares, Milca Magalhães Dias de Carvalho
Alves, Juliana Osório
Soares, Paula Matias
Leal-Cardoso, José Henrique
Loureiro, Adriano César Carneiro
Ferraz, Alex Soares Marreiros
Carvalho, Denise Pires de
Ceccatto, Vânia Marilande
author_role author
author2 Felipe, Stela Mirla da Silva
Soares, Milca Magalhães Dias de Carvalho
Alves, Juliana Osório
Soares, Paula Matias
Leal-Cardoso, José Henrique
Loureiro, Adriano César Carneiro
Ferraz, Alex Soares Marreiros
Carvalho, Denise Pires de
Ceccatto, Vânia Marilande
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pacheco, Christina
Felipe, Stela Mirla da Silva
Soares, Milca Magalhães Dias de Carvalho
Alves, Juliana Osório
Soares, Paula Matias
Leal-Cardoso, José Henrique
Loureiro, Adriano César Carneiro
Ferraz, Alex Soares Marreiros
Carvalho, Denise Pires de
Ceccatto, Vânia Marilande
dc.subject.por.fl_str_mv Ontologia genética do exercício
Genômica do exercício
Genes ligados ao exercício físico
Fisiologia do exercício molecular
Transcriptoma de exercício físico
topic Ontologia genética do exercício
Genômica do exercício
Genes ligados ao exercício físico
Fisiologia do exercício molecular
Transcriptoma de exercício físico
description : Regular exercise is an exogenous factor of gene regulation with numerous health benefits. The study aimed to evaluate human genes linked to physical exercise in an ‘omic scale, addressing biological questions to the generated database. Three literature databases were searched with the terms ‘exercise’, ‘fitness’, ‘physical activity’, ‘genetics’ and ‘gene expression’. For additional references, papers were scrutinized and a textmining tool was used. Papers linking genes to exercise in humans through microarray, RNA-Seq, RT-PCR and genotyping studies were included. Genes were extracted from the collected literature, together with information on exercise protocol, experimental design, gender, age, number of individuals, analytical method, fold change and statistical data. The ‘omic scale dataset was characterized and evaluated with bioinformatics tools searching for gene expression patterns, functional meaning and gene clusters. As a result, a physical exercise-related human gene compendium was created, with data from 58 scientific papers and 5.147 genes functionally correlated with 17 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. While 50.9% of the gene set was up-regulated, 41.9% was down-regulated. 743 up- and 530 down-regulated clusters were found, some connected by regulatory networks. To summarize, up- and down-regulation was encountered, with a wide genomic distribution of the gene set and up- and down-regulated clusters possibly assembled by functional gene evolution. Physical exercise elicits a widespread response in gene expression.
publishDate 2018
dc.date.none.fl_str_mv 2018
2021-08-02T22:08:38Z
2021-08-02T22:08:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv PACHECO, Christina et al. A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi, BIOLOGY OF SPORT, [s. l.], v.35, p.1-11, 2018
http://www.repositorio.ufc.br/handle/riufc/59822
identifier_str_mv PACHECO, Christina et al. A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi, BIOLOGY OF SPORT, [s. l.], v.35, p.1-11, 2018
url http://www.repositorio.ufc.br/handle/riufc/59822
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BIOLOGY OF SPORT
publisher.none.fl_str_mv BIOLOGY OF SPORT
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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