Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels
| Autor(a) principal: | |
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| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
| Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/30492 |
Resumo: | CHAVES, Hellíada Vasconcelos |
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Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channelsArticulação TemporomandibularTemporomandibular JointCHAVES, Hellíada VasconcelosObjective and design To investigate the role of heme oxygenase-1 (HO-1), carbon monoxide (CO), and biliverdin (BVD) in the zymosan-induced TMJ arthritis in rats. Materials and Methods Mechanical threshold was assessed before and 4 h after TMJ arthritis induction in rats. Cell influx, myeloperoxidase activity, and histological changes were measured in the TMJ lavages and tissues. Trigeminal ganglion and periarticular tissues were used for HO-1, TNF-α, and IL-1β mRNA time course expression and immunohistochemical analyses. Hemin (0.1, 0.3, or 1 mg kg−1), DMDC (0.025, 0.25, or 2.5 µmol kg−1), biliverdin (1, 3, or 10 mg kg−1), or ZnPP-IX (1, 3 or 9 mg kg−1) were injected (s.c.) 60 min before zymosan. ODQ (12.5 µmol kg−1; s.c.) or glibenclamide (10 mg kg−1; i.p.) was administered 1 h and 30 min prior to DMDC (2.5 µmol kg−1; s.c), respectively. Results Hemin (1 mg kg−1), DMDC (2.5 µmol kg−1), and BVD (10 mg kg−1) reduced hypernociception and leukocyte migration, which ZnPP (3 mg kg−1) enhanced. The effects of DMDC were counteracted by ODQ and glibenclamide. The HO-1, TNF-α, and IL-1β mRNA expression and immunolabelling increased. Conclusions HO-1/BVD/CO pathway activation provides anti-nociceptive and anti-inflammatory effects on the zymosan-induced TMJ hypernociception in rats.Inflammation Research2018-03-21T18:40:57Z2018-03-21T18:40:57Z2018-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfCHAVES, H. V. et al. Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels. Inflammation Research, Basel, p. 1-16, jan. 2018.1023-3830 (Print)1420-908X (Online)http://www.repositorio.ufc.br/handle/riufc/30492Chaves, Hellíada VasconcelosVal, Danielle Rocha doRibeiro, Kátia AlvesLemos, Jonas CavalcanteSouza, Ricardo BastoGomes, Francisco Isaac FernandesCunha, Rodrigo Maranguape Silva daPinto, Vicente de Paulo TeixeiraCristino Filho, GerardoSouza, Marcellus Henrique Loiola Ponte deBezerra, Mirna MarquesBrito, Gerly Anne de Castroengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-17T16:45:43Zoai:repositorio.ufc.br:riufc/30492Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:27:11.804127Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
| dc.title.none.fl_str_mv |
Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels |
| title |
Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels |
| spellingShingle |
Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels Chaves, Hellíada Vasconcelos Articulação Temporomandibular Temporomandibular Joint |
| title_short |
Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels |
| title_full |
Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels |
| title_fullStr |
Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels |
| title_full_unstemmed |
Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels |
| title_sort |
Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels |
| author |
Chaves, Hellíada Vasconcelos |
| author_facet |
Chaves, Hellíada Vasconcelos Val, Danielle Rocha do Ribeiro, Kátia Alves Lemos, Jonas Cavalcante Souza, Ricardo Basto Gomes, Francisco Isaac Fernandes Cunha, Rodrigo Maranguape Silva da Pinto, Vicente de Paulo Teixeira Cristino Filho, Gerardo Souza, Marcellus Henrique Loiola Ponte de Bezerra, Mirna Marques Brito, Gerly Anne de Castro |
| author_role |
author |
| author2 |
Val, Danielle Rocha do Ribeiro, Kátia Alves Lemos, Jonas Cavalcante Souza, Ricardo Basto Gomes, Francisco Isaac Fernandes Cunha, Rodrigo Maranguape Silva da Pinto, Vicente de Paulo Teixeira Cristino Filho, Gerardo Souza, Marcellus Henrique Loiola Ponte de Bezerra, Mirna Marques Brito, Gerly Anne de Castro |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Chaves, Hellíada Vasconcelos Val, Danielle Rocha do Ribeiro, Kátia Alves Lemos, Jonas Cavalcante Souza, Ricardo Basto Gomes, Francisco Isaac Fernandes Cunha, Rodrigo Maranguape Silva da Pinto, Vicente de Paulo Teixeira Cristino Filho, Gerardo Souza, Marcellus Henrique Loiola Ponte de Bezerra, Mirna Marques Brito, Gerly Anne de Castro |
| dc.subject.por.fl_str_mv |
Articulação Temporomandibular Temporomandibular Joint |
| topic |
Articulação Temporomandibular Temporomandibular Joint |
| description |
CHAVES, Hellíada Vasconcelos |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-03-21T18:40:57Z 2018-03-21T18:40:57Z 2018-01 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
CHAVES, H. V. et al. Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels. Inflammation Research, Basel, p. 1-16, jan. 2018. 1023-3830 (Print) 1420-908X (Online) http://www.repositorio.ufc.br/handle/riufc/30492 |
| identifier_str_mv |
CHAVES, H. V. et al. Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels. Inflammation Research, Basel, p. 1-16, jan. 2018. 1023-3830 (Print) 1420-908X (Online) |
| url |
http://www.repositorio.ufc.br/handle/riufc/30492 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Inflammation Research |
| publisher.none.fl_str_mv |
Inflammation Research |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
| instname_str |
Universidade Federal do Ceará (UFC) |
| instacron_str |
UFC |
| institution |
UFC |
| reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
| collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
| repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
| repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
| _version_ |
1813028809865166848 |