Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/32402 |
Resumo: | We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer’s disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27th, 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects metaanalyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies. Twenty-five studies met eligibility criteria. Use of statins was significantly associated with a reduced risk of all-caused dementia (k = 16 studies, adjusted RR (aRR) = 0.849, 95% CI = 0.787–0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95% CI = 0.576–0.899, p = 0.004), and MCI (k = 6, aRR = 0.737, 95% CI = 0.556– 0.976, p = 0.033), but no meaningful effects on incident VaD (k = 3, aRR = 1.012, 95% CI = 0.620–1.652, p = 0.961). Subgroup analysis suggested that hydrophilic statins were associated with reduced risk of all-caused dementia (aRR = 0.877; CI = 0.818–0.940; p = 0.000) and possibly lower AD risk (aRR = 0.619; CI = 0.383–1.000; p = 0.050). Lipophilic statins were associated with reduced risk of AD (aRR = 0.639; CI = 0.449–0.908; p = 0.013) but not all-caused dementia (aRR = 0.738; CI = 0.475–1.146; p = 0.176). In conclusion, our meta-analysis suggests that the use of statins may reduce the risk of all-type dementia, AD, and MCI, but not of incident VaD. |
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Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysisInibidores de Hidroximetilglutaril-CoA RedutasesHydroxymethylglutaryl-CoA Reductase InhibitorsDementiaDemênciaWe conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer’s disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27th, 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects metaanalyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies. Twenty-five studies met eligibility criteria. Use of statins was significantly associated with a reduced risk of all-caused dementia (k = 16 studies, adjusted RR (aRR) = 0.849, 95% CI = 0.787–0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95% CI = 0.576–0.899, p = 0.004), and MCI (k = 6, aRR = 0.737, 95% CI = 0.556– 0.976, p = 0.033), but no meaningful effects on incident VaD (k = 3, aRR = 1.012, 95% CI = 0.620–1.652, p = 0.961). Subgroup analysis suggested that hydrophilic statins were associated with reduced risk of all-caused dementia (aRR = 0.877; CI = 0.818–0.940; p = 0.000) and possibly lower AD risk (aRR = 0.619; CI = 0.383–1.000; p = 0.050). Lipophilic statins were associated with reduced risk of AD (aRR = 0.639; CI = 0.449–0.908; p = 0.013) but not all-caused dementia (aRR = 0.738; CI = 0.475–1.146; p = 0.176). In conclusion, our meta-analysis suggests that the use of statins may reduce the risk of all-type dementia, AD, and MCI, but not of incident VaD.Scientific Reports2018-05-29T17:54:03Z2018-05-29T17:54:03Z2018-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfCHU, C.-S. et al. Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis. Scientific Reports, 8:5804, apr. 2018.2045-23222045-2322 (On line)http://www.repositorio.ufc.br/handle/riufc/32402Chu, Che-ShengTseng, Ping-TaoStubbs, BrendonChen, Tien-YuTang, Chia-HungLi, Dian-JengYang, Wei-ChengChen, Yen-WenWu, Ching-KuanVeronese, NicolaCarvalho, Andre F.Fernandes, Brisa S.Herrmann, NathanLin, Pao-Yenengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2021-03-29T17:44:00Zoai:repositorio.ufc.br:riufc/32402Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:58:00.879903Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis |
title |
Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis |
spellingShingle |
Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis Chu, Che-Sheng Inibidores de Hidroximetilglutaril-CoA Redutases Hydroxymethylglutaryl-CoA Reductase Inhibitors Dementia Demência |
title_short |
Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis |
title_full |
Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis |
title_fullStr |
Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis |
title_full_unstemmed |
Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis |
title_sort |
Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis |
author |
Chu, Che-Sheng |
author_facet |
Chu, Che-Sheng Tseng, Ping-Tao Stubbs, Brendon Chen, Tien-Yu Tang, Chia-Hung Li, Dian-Jeng Yang, Wei-Cheng Chen, Yen-Wen Wu, Ching-Kuan Veronese, Nicola Carvalho, Andre F. Fernandes, Brisa S. Herrmann, Nathan Lin, Pao-Yen |
author_role |
author |
author2 |
Tseng, Ping-Tao Stubbs, Brendon Chen, Tien-Yu Tang, Chia-Hung Li, Dian-Jeng Yang, Wei-Cheng Chen, Yen-Wen Wu, Ching-Kuan Veronese, Nicola Carvalho, Andre F. Fernandes, Brisa S. Herrmann, Nathan Lin, Pao-Yen |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Chu, Che-Sheng Tseng, Ping-Tao Stubbs, Brendon Chen, Tien-Yu Tang, Chia-Hung Li, Dian-Jeng Yang, Wei-Cheng Chen, Yen-Wen Wu, Ching-Kuan Veronese, Nicola Carvalho, Andre F. Fernandes, Brisa S. Herrmann, Nathan Lin, Pao-Yen |
dc.subject.por.fl_str_mv |
Inibidores de Hidroximetilglutaril-CoA Redutases Hydroxymethylglutaryl-CoA Reductase Inhibitors Dementia Demência |
topic |
Inibidores de Hidroximetilglutaril-CoA Redutases Hydroxymethylglutaryl-CoA Reductase Inhibitors Dementia Demência |
description |
We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer’s disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27th, 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects metaanalyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies. Twenty-five studies met eligibility criteria. Use of statins was significantly associated with a reduced risk of all-caused dementia (k = 16 studies, adjusted RR (aRR) = 0.849, 95% CI = 0.787–0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95% CI = 0.576–0.899, p = 0.004), and MCI (k = 6, aRR = 0.737, 95% CI = 0.556– 0.976, p = 0.033), but no meaningful effects on incident VaD (k = 3, aRR = 1.012, 95% CI = 0.620–1.652, p = 0.961). Subgroup analysis suggested that hydrophilic statins were associated with reduced risk of all-caused dementia (aRR = 0.877; CI = 0.818–0.940; p = 0.000) and possibly lower AD risk (aRR = 0.619; CI = 0.383–1.000; p = 0.050). Lipophilic statins were associated with reduced risk of AD (aRR = 0.639; CI = 0.449–0.908; p = 0.013) but not all-caused dementia (aRR = 0.738; CI = 0.475–1.146; p = 0.176). In conclusion, our meta-analysis suggests that the use of statins may reduce the risk of all-type dementia, AD, and MCI, but not of incident VaD. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-05-29T17:54:03Z 2018-05-29T17:54:03Z 2018-04 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
CHU, C.-S. et al. Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis. Scientific Reports, 8:5804, apr. 2018. 2045-2322 2045-2322 (On line) http://www.repositorio.ufc.br/handle/riufc/32402 |
identifier_str_mv |
CHU, C.-S. et al. Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis. Scientific Reports, 8:5804, apr. 2018. 2045-2322 2045-2322 (On line) |
url |
http://www.repositorio.ufc.br/handle/riufc/32402 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Scientific Reports |
publisher.none.fl_str_mv |
Scientific Reports |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
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