Tropane alkaloids from the stem bark of Erythroxylum bezerrae
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
| Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/64080 |
Resumo: | Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activity with IC50 values of 3.38 and 5.43 μM for HCT-116 and NCI-H460, respectively |
| id |
UFC-7_3df3e5a72a9961ce2502ee5c855958cc |
|---|---|
| oai_identifier_str |
oai:repositorio.ufc.br:riufc/64080 |
| network_acronym_str |
UFC-7 |
| network_name_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
| repository_id_str |
|
| spelling |
Tropane alkaloids from the stem bark of Erythroxylum bezerraeErythroxylum bezerrae PlowmanErythroxylaceaeTropane alkaloidsCytotoxic activitySix previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activity with IC50 values of 3.38 and 5.43 μM for HCT-116 and NCI-H460, respectivelyPhytochemistry2022-02-21T15:44:29Z2022-02-21T15:44:29Z2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBRITO, Luana San de O. et al. Tropane alkaloids from the stem bark of Erythroxylum bezerrae. Phytochemistry, [s. l.], v. 178, p. 1-9, 2020.http://www.repositorio.ufc.br/handle/riufc/64080Brito, Luana San de O.Pinto, Francisco das Chagas L.Moraes Filho, Manoel Odorico deRocha, Danilo D.Mendoza, Maria Fernanda M.Ayala, Alejandro PedroBezerra, Beatriz PinheiroLoiola, Maria Iracema B.Canuto, Kirley MarquesSilveira, Edilberto R.Pessoa, Otilia Deusdenia L.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFC2023-10-10T19:42:59Zoai:repositorio.ufc.br:riufc/64080Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T19:02:42.524073Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
| dc.title.none.fl_str_mv |
Tropane alkaloids from the stem bark of Erythroxylum bezerrae |
| title |
Tropane alkaloids from the stem bark of Erythroxylum bezerrae |
| spellingShingle |
Tropane alkaloids from the stem bark of Erythroxylum bezerrae Brito, Luana San de O. Erythroxylum bezerrae Plowman Erythroxylaceae Tropane alkaloids Cytotoxic activity |
| title_short |
Tropane alkaloids from the stem bark of Erythroxylum bezerrae |
| title_full |
Tropane alkaloids from the stem bark of Erythroxylum bezerrae |
| title_fullStr |
Tropane alkaloids from the stem bark of Erythroxylum bezerrae |
| title_full_unstemmed |
Tropane alkaloids from the stem bark of Erythroxylum bezerrae |
| title_sort |
Tropane alkaloids from the stem bark of Erythroxylum bezerrae |
| author |
Brito, Luana San de O. |
| author_facet |
Brito, Luana San de O. Pinto, Francisco das Chagas L. Moraes Filho, Manoel Odorico de Rocha, Danilo D. Mendoza, Maria Fernanda M. Ayala, Alejandro Pedro Bezerra, Beatriz Pinheiro Loiola, Maria Iracema B. Canuto, Kirley Marques Silveira, Edilberto R. Pessoa, Otilia Deusdenia L. |
| author_role |
author |
| author2 |
Pinto, Francisco das Chagas L. Moraes Filho, Manoel Odorico de Rocha, Danilo D. Mendoza, Maria Fernanda M. Ayala, Alejandro Pedro Bezerra, Beatriz Pinheiro Loiola, Maria Iracema B. Canuto, Kirley Marques Silveira, Edilberto R. Pessoa, Otilia Deusdenia L. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Brito, Luana San de O. Pinto, Francisco das Chagas L. Moraes Filho, Manoel Odorico de Rocha, Danilo D. Mendoza, Maria Fernanda M. Ayala, Alejandro Pedro Bezerra, Beatriz Pinheiro Loiola, Maria Iracema B. Canuto, Kirley Marques Silveira, Edilberto R. Pessoa, Otilia Deusdenia L. |
| dc.subject.por.fl_str_mv |
Erythroxylum bezerrae Plowman Erythroxylaceae Tropane alkaloids Cytotoxic activity |
| topic |
Erythroxylum bezerrae Plowman Erythroxylaceae Tropane alkaloids Cytotoxic activity |
| description |
Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activity with IC50 values of 3.38 and 5.43 μM for HCT-116 and NCI-H460, respectively |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2022-02-21T15:44:29Z 2022-02-21T15:44:29Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
BRITO, Luana San de O. et al. Tropane alkaloids from the stem bark of Erythroxylum bezerrae. Phytochemistry, [s. l.], v. 178, p. 1-9, 2020. http://www.repositorio.ufc.br/handle/riufc/64080 |
| identifier_str_mv |
BRITO, Luana San de O. et al. Tropane alkaloids from the stem bark of Erythroxylum bezerrae. Phytochemistry, [s. l.], v. 178, p. 1-9, 2020. |
| url |
http://www.repositorio.ufc.br/handle/riufc/64080 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Phytochemistry |
| publisher.none.fl_str_mv |
Phytochemistry |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
| instname_str |
Universidade Federal do Ceará (UFC) |
| instacron_str |
UFC |
| institution |
UFC |
| reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
| collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
| repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
| repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
| _version_ |
1813029045185544192 |