Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells: involvement of NAD(P)H :quinone oxidoreductase (NQO1)

Detalhes bibliográficos
Autor(a) principal: Cavalcanti, Bruno C.
Data de Publicação: 2013
Outros Autores: Magalhães, Hemerson I. F., Rodrigues, Felipe A. R., Moraes Filho, Manoel Odorico de, Pessoa, Cláudia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/7232
Resumo: b-lapachone, a DNA repair inhibitor, has been recognized as important prototype with activity against cancer cells devoided of cytotoxicity in non-tumor cells. NQO1 is a reductive enzyme that is important for the activation of many bioreductive quinones. Thus, differential levels of NQO1 in tissues, including tumors, can provide a target for an enzyme-directed approach to cancer therapy. Herein, we aimed to evaluate the role of NQO1 on the cytotoxicity of 3-arylamino-nor-b-lapachone derivative using the prostate DU-145 (NQO1-overexpressing) and LNCap (NQO1-deficient) cells.
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spelling Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells: involvement of NAD(P)H :quinone oxidoreductase (NQO1)ApoptoseNeoplasias da Próstatab-lapachone, a DNA repair inhibitor, has been recognized as important prototype with activity against cancer cells devoided of cytotoxicity in non-tumor cells. NQO1 is a reductive enzyme that is important for the activation of many bioreductive quinones. Thus, differential levels of NQO1 in tissues, including tumors, can provide a target for an enzyme-directed approach to cancer therapy. Herein, we aimed to evaluate the role of NQO1 on the cytotoxicity of 3-arylamino-nor-b-lapachone derivative using the prostate DU-145 (NQO1-overexpressing) and LNCap (NQO1-deficient) cells.BMC Proceedings2014-02-10T16:43:53Z2014-02-10T16:43:53Z2013-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfCAVALCANTI, B. C. et al. Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells : involvement of NAD(P)H quinone oxidoreductase (NQO1). BMC Proceedings, São Paulo, SP, v. 7, supl. 2, p. 12-12, abr. 2013.http://www.repositorio.ufc.br/handle/riufc/7232Cavalcanti, Bruno C.Magalhães, Hemerson I. F.Rodrigues, Felipe A. R.Moraes Filho, Manoel Odorico dePessoa, Cláudiaengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2020-08-10T12:38:08Zoai:repositorio.ufc.br:riufc/7232Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:32:16.177471Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells: involvement of NAD(P)H :quinone oxidoreductase (NQO1)
title Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells: involvement of NAD(P)H :quinone oxidoreductase (NQO1)
spellingShingle Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells: involvement of NAD(P)H :quinone oxidoreductase (NQO1)
Cavalcanti, Bruno C.
Apoptose
Neoplasias da Próstata
title_short Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells: involvement of NAD(P)H :quinone oxidoreductase (NQO1)
title_full Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells: involvement of NAD(P)H :quinone oxidoreductase (NQO1)
title_fullStr Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells: involvement of NAD(P)H :quinone oxidoreductase (NQO1)
title_full_unstemmed Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells: involvement of NAD(P)H :quinone oxidoreductase (NQO1)
title_sort Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells: involvement of NAD(P)H :quinone oxidoreductase (NQO1)
author Cavalcanti, Bruno C.
author_facet Cavalcanti, Bruno C.
Magalhães, Hemerson I. F.
Rodrigues, Felipe A. R.
Moraes Filho, Manoel Odorico de
Pessoa, Cláudia
author_role author
author2 Magalhães, Hemerson I. F.
Rodrigues, Felipe A. R.
Moraes Filho, Manoel Odorico de
Pessoa, Cláudia
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cavalcanti, Bruno C.
Magalhães, Hemerson I. F.
Rodrigues, Felipe A. R.
Moraes Filho, Manoel Odorico de
Pessoa, Cláudia
dc.subject.por.fl_str_mv Apoptose
Neoplasias da Próstata
topic Apoptose
Neoplasias da Próstata
description b-lapachone, a DNA repair inhibitor, has been recognized as important prototype with activity against cancer cells devoided of cytotoxicity in non-tumor cells. NQO1 is a reductive enzyme that is important for the activation of many bioreductive quinones. Thus, differential levels of NQO1 in tissues, including tumors, can provide a target for an enzyme-directed approach to cancer therapy. Herein, we aimed to evaluate the role of NQO1 on the cytotoxicity of 3-arylamino-nor-b-lapachone derivative using the prostate DU-145 (NQO1-overexpressing) and LNCap (NQO1-deficient) cells.
publishDate 2013
dc.date.none.fl_str_mv 2013-04
2014-02-10T16:43:53Z
2014-02-10T16:43:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv CAVALCANTI, B. C. et al. Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells : involvement of NAD(P)H quinone oxidoreductase (NQO1). BMC Proceedings, São Paulo, SP, v. 7, supl. 2, p. 12-12, abr. 2013.
http://www.repositorio.ufc.br/handle/riufc/7232
identifier_str_mv CAVALCANTI, B. C. et al. Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells : involvement of NAD(P)H quinone oxidoreductase (NQO1). BMC Proceedings, São Paulo, SP, v. 7, supl. 2, p. 12-12, abr. 2013.
url http://www.repositorio.ufc.br/handle/riufc/7232
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC Proceedings
publisher.none.fl_str_mv BMC Proceedings
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1813028845947715584

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