Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/5088 |
Resumo: | The antinociceptive effects of interleukin (IL)-4, -10, and -13 were investigated in two different experimental pain models. Our results showed that pretreatment (30 min) with IL-4 (1–5 ng/animal), IL-10 (0.4–10 ng/animal), or IL-13 (0.4 –2.5 ng/animal) inhibited the writhing response induced by the i.p. administration of acetic acid (53–89%) or zymosan (63–74%) in mice, and the knee joint incapacitation induced by i.a. injection of zymosan (49–66%) in rats. Neither of the cytokines affected the pain elicited in mice using the hot-plate test. This analgesic effect of IL-4, -10, and -13 was not reversed by the combined pretreatment with the opioid receptor antagonist naloxone. IL-4, -10, or -13 significantly inhibited the release of both tumor necrosis factor (TNF)- (60, 53, and 100%, respectively) and IL-1 (80, 100, and 100%, respectively) by mice peritoneal macrophages obtained after local (i.p.) injection of zymosan. Antisera against IL-4, -10, and -13 potentiated both the zymosan- induced writhing response and the articular incapacitation. Our results demonstrate that IL-4, -10, and -13 display analgesic activity that is probably not due to endogenous opioid release. This analgesic effect could be related to a peripheral mechanism, probably via the inhibition of the release of the pro-inflammatory cytokines TNF- and IL-1 by resident peritoneal macrophages. |
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Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in ratsInterleucina-4Interleucina-10Interleucina-13Articulação do JoelhoThe antinociceptive effects of interleukin (IL)-4, -10, and -13 were investigated in two different experimental pain models. Our results showed that pretreatment (30 min) with IL-4 (1–5 ng/animal), IL-10 (0.4–10 ng/animal), or IL-13 (0.4 –2.5 ng/animal) inhibited the writhing response induced by the i.p. administration of acetic acid (53–89%) or zymosan (63–74%) in mice, and the knee joint incapacitation induced by i.a. injection of zymosan (49–66%) in rats. Neither of the cytokines affected the pain elicited in mice using the hot-plate test. This analgesic effect of IL-4, -10, and -13 was not reversed by the combined pretreatment with the opioid receptor antagonist naloxone. IL-4, -10, or -13 significantly inhibited the release of both tumor necrosis factor (TNF)- (60, 53, and 100%, respectively) and IL-1 (80, 100, and 100%, respectively) by mice peritoneal macrophages obtained after local (i.p.) injection of zymosan. Antisera against IL-4, -10, and -13 potentiated both the zymosan- induced writhing response and the articular incapacitation. Our results demonstrate that IL-4, -10, and -13 display analgesic activity that is probably not due to endogenous opioid release. This analgesic effect could be related to a peripheral mechanism, probably via the inhibition of the release of the pro-inflammatory cytokines TNF- and IL-1 by resident peritoneal macrophages.The Journal of Pharmacology and Experimental Therapeutics2013-06-18T15:36:10Z2013-06-18T15:36:10Z2003-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfVALE, M. L. et al. Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats. The Journal of Pharmacology and Experimental Therapeutics, Rockville Pike Bethesda, Maryland, v. 304, n. 1, p. 102-108, jan. 2003.0022-3563http://www.repositorio.ufc.br/handle/riufc/5088Vale, Mariana L.Marques, Jaciara B.Moreira, Camila A.Rocha, Francisco Aírton C.Ferreira, Sérgio H.Poole, StephenCunha, Fernando Q.Ribeiro, Ronaldo A.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-21T12:11:03Zoai:repositorio.ufc.br:riufc/5088Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2019-01-21T12:11:03Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats |
title |
Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats |
spellingShingle |
Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats Vale, Mariana L. Interleucina-4 Interleucina-10 Interleucina-13 Articulação do Joelho |
title_short |
Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats |
title_full |
Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats |
title_fullStr |
Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats |
title_full_unstemmed |
Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats |
title_sort |
Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats |
author |
Vale, Mariana L. |
author_facet |
Vale, Mariana L. Marques, Jaciara B. Moreira, Camila A. Rocha, Francisco Aírton C. Ferreira, Sérgio H. Poole, Stephen Cunha, Fernando Q. Ribeiro, Ronaldo A. |
author_role |
author |
author2 |
Marques, Jaciara B. Moreira, Camila A. Rocha, Francisco Aírton C. Ferreira, Sérgio H. Poole, Stephen Cunha, Fernando Q. Ribeiro, Ronaldo A. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Vale, Mariana L. Marques, Jaciara B. Moreira, Camila A. Rocha, Francisco Aírton C. Ferreira, Sérgio H. Poole, Stephen Cunha, Fernando Q. Ribeiro, Ronaldo A. |
dc.subject.por.fl_str_mv |
Interleucina-4 Interleucina-10 Interleucina-13 Articulação do Joelho |
topic |
Interleucina-4 Interleucina-10 Interleucina-13 Articulação do Joelho |
description |
The antinociceptive effects of interleukin (IL)-4, -10, and -13 were investigated in two different experimental pain models. Our results showed that pretreatment (30 min) with IL-4 (1–5 ng/animal), IL-10 (0.4–10 ng/animal), or IL-13 (0.4 –2.5 ng/animal) inhibited the writhing response induced by the i.p. administration of acetic acid (53–89%) or zymosan (63–74%) in mice, and the knee joint incapacitation induced by i.a. injection of zymosan (49–66%) in rats. Neither of the cytokines affected the pain elicited in mice using the hot-plate test. This analgesic effect of IL-4, -10, and -13 was not reversed by the combined pretreatment with the opioid receptor antagonist naloxone. IL-4, -10, or -13 significantly inhibited the release of both tumor necrosis factor (TNF)- (60, 53, and 100%, respectively) and IL-1 (80, 100, and 100%, respectively) by mice peritoneal macrophages obtained after local (i.p.) injection of zymosan. Antisera against IL-4, -10, and -13 potentiated both the zymosan- induced writhing response and the articular incapacitation. Our results demonstrate that IL-4, -10, and -13 display analgesic activity that is probably not due to endogenous opioid release. This analgesic effect could be related to a peripheral mechanism, probably via the inhibition of the release of the pro-inflammatory cytokines TNF- and IL-1 by resident peritoneal macrophages. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-01 2013-06-18T15:36:10Z 2013-06-18T15:36:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
VALE, M. L. et al. Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats. The Journal of Pharmacology and Experimental Therapeutics, Rockville Pike Bethesda, Maryland, v. 304, n. 1, p. 102-108, jan. 2003. 0022-3563 http://www.repositorio.ufc.br/handle/riufc/5088 |
identifier_str_mv |
VALE, M. L. et al. Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats. The Journal of Pharmacology and Experimental Therapeutics, Rockville Pike Bethesda, Maryland, v. 304, n. 1, p. 102-108, jan. 2003. 0022-3563 |
url |
http://www.repositorio.ufc.br/handle/riufc/5088 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
The Journal of Pharmacology and Experimental Therapeutics |
publisher.none.fl_str_mv |
The Journal of Pharmacology and Experimental Therapeutics |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
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1809935799808950272 |