Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/17631 |
Resumo: | Objective We investigated the anti-inflammatory activity of strontium ranelate (SR) in arthritis models. Materials and methods Rats received 1 mg zymosan (Zy) or saline intra-articularly. Other groups were subjected to anterior cruciate ligament transection in the right knee, as an osteoarthritis (OA) model, or a sham procedure. Joint pain was assessed using the articular incapacitation and paw-pressure tests. Cell influx and cytokines were measured in joint exudates. Treatment Groups received either SR (30–300 mg/kg per os) or saline. Results SR dose-dependently and significantly inhibited joint pain in both Zy and OA models, while not altering cell influx. Naloxone administration significantly reversed SR analgesia. SR significantly reduced levels of Interleukin-1β and tumor necrosis factor-α in Zy arthritis, whereas those of cytokine-induced neutrophil chemoattractant (CINC)-1 were not altered. Conclusions SR provides analgesia in arthritis that is associated to inhibition of the release of inflammatory cytokines into inflamed joints. This effect is abrogated by administration of the opioid antagonist naloxone. |
id |
UFC-7_687214ee1536196d3d18aec483fe19b1 |
---|---|
oai_identifier_str |
oai:repositorio.ufc.br:riufc/17631 |
network_acronym_str |
UFC-7 |
network_name_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository_id_str |
|
spelling |
Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanismsArtriteCitocinasZimosanObjective We investigated the anti-inflammatory activity of strontium ranelate (SR) in arthritis models. Materials and methods Rats received 1 mg zymosan (Zy) or saline intra-articularly. Other groups were subjected to anterior cruciate ligament transection in the right knee, as an osteoarthritis (OA) model, or a sham procedure. Joint pain was assessed using the articular incapacitation and paw-pressure tests. Cell influx and cytokines were measured in joint exudates. Treatment Groups received either SR (30–300 mg/kg per os) or saline. Results SR dose-dependently and significantly inhibited joint pain in both Zy and OA models, while not altering cell influx. Naloxone administration significantly reversed SR analgesia. SR significantly reduced levels of Interleukin-1β and tumor necrosis factor-α in Zy arthritis, whereas those of cytokine-induced neutrophil chemoattractant (CINC)-1 were not altered. Conclusions SR provides analgesia in arthritis that is associated to inhibition of the release of inflammatory cytokines into inflamed joints. This effect is abrogated by administration of the opioid antagonist naloxone.Inflammation Research2016-06-13T16:50:06Z2016-06-13T16:50:06Z2015-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfNUNES, R. M. et al. Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms. Inflammation Research, Basel, v. 64, n. 10, p. 781-787, oct. 2015.1023-3830http://www.repositorio.ufc.br/handle/riufc/17631Nunes, Rodolfo de MeloMartins, Morgana RamosSilva Junior, Francisco Saraiva daLeite, Ana Caroline Rocha de MeloGirão, Virgínia Cláudia CarneiroCunha, Fernando de QueirozMarinho, Aryana Lushese Lima FeitosaPinto, Ana Carolina Matias DinellyRocha, Francisco Airton Castroengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-03-11T13:13:55Zoai:repositorio.ufc.br:riufc/17631Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2022-03-11T13:13:55Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms |
title |
Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms |
spellingShingle |
Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms Nunes, Rodolfo de Melo Artrite Citocinas Zimosan |
title_short |
Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms |
title_full |
Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms |
title_fullStr |
Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms |
title_full_unstemmed |
Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms |
title_sort |
Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms |
author |
Nunes, Rodolfo de Melo |
author_facet |
Nunes, Rodolfo de Melo Martins, Morgana Ramos Silva Junior, Francisco Saraiva da Leite, Ana Caroline Rocha de Melo Girão, Virgínia Cláudia Carneiro Cunha, Fernando de Queiroz Marinho, Aryana Lushese Lima Feitosa Pinto, Ana Carolina Matias Dinelly Rocha, Francisco Airton Castro |
author_role |
author |
author2 |
Martins, Morgana Ramos Silva Junior, Francisco Saraiva da Leite, Ana Caroline Rocha de Melo Girão, Virgínia Cláudia Carneiro Cunha, Fernando de Queiroz Marinho, Aryana Lushese Lima Feitosa Pinto, Ana Carolina Matias Dinelly Rocha, Francisco Airton Castro |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nunes, Rodolfo de Melo Martins, Morgana Ramos Silva Junior, Francisco Saraiva da Leite, Ana Caroline Rocha de Melo Girão, Virgínia Cláudia Carneiro Cunha, Fernando de Queiroz Marinho, Aryana Lushese Lima Feitosa Pinto, Ana Carolina Matias Dinelly Rocha, Francisco Airton Castro |
dc.subject.por.fl_str_mv |
Artrite Citocinas Zimosan |
topic |
Artrite Citocinas Zimosan |
description |
Objective We investigated the anti-inflammatory activity of strontium ranelate (SR) in arthritis models. Materials and methods Rats received 1 mg zymosan (Zy) or saline intra-articularly. Other groups were subjected to anterior cruciate ligament transection in the right knee, as an osteoarthritis (OA) model, or a sham procedure. Joint pain was assessed using the articular incapacitation and paw-pressure tests. Cell influx and cytokines were measured in joint exudates. Treatment Groups received either SR (30–300 mg/kg per os) or saline. Results SR dose-dependently and significantly inhibited joint pain in both Zy and OA models, while not altering cell influx. Naloxone administration significantly reversed SR analgesia. SR significantly reduced levels of Interleukin-1β and tumor necrosis factor-α in Zy arthritis, whereas those of cytokine-induced neutrophil chemoattractant (CINC)-1 were not altered. Conclusions SR provides analgesia in arthritis that is associated to inhibition of the release of inflammatory cytokines into inflamed joints. This effect is abrogated by administration of the opioid antagonist naloxone. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10 2016-06-13T16:50:06Z 2016-06-13T16:50:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
NUNES, R. M. et al. Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms. Inflammation Research, Basel, v. 64, n. 10, p. 781-787, oct. 2015. 1023-3830 http://www.repositorio.ufc.br/handle/riufc/17631 |
identifier_str_mv |
NUNES, R. M. et al. Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms. Inflammation Research, Basel, v. 64, n. 10, p. 781-787, oct. 2015. 1023-3830 |
url |
http://www.repositorio.ufc.br/handle/riufc/17631 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Inflammation Research |
publisher.none.fl_str_mv |
Inflammation Research |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1823806493449781248 |