Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms

Detalhes bibliográficos
Autor(a) principal: Nunes, Rodolfo de Melo
Data de Publicação: 2015
Outros Autores: Martins, Morgana Ramos, Silva Junior, Francisco Saraiva da, Leite, Ana Caroline Rocha de Melo, Girão, Virgínia Cláudia Carneiro, Cunha, Fernando de Queiroz, Marinho, Aryana Lushese Lima Feitosa, Pinto, Ana Carolina Matias Dinelly, Rocha, Francisco Airton Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/17631
Resumo: Objective We investigated the anti-inflammatory activity of strontium ranelate (SR) in arthritis models. Materials and methods Rats received 1 mg zymosan (Zy) or saline intra-articularly. Other groups were subjected to anterior cruciate ligament transection in the right knee, as an osteoarthritis (OA) model, or a sham procedure. Joint pain was assessed using the articular incapacitation and paw-pressure tests. Cell influx and cytokines were measured in joint exudates. Treatment Groups received either SR (30–300 mg/kg per os) or saline. Results SR dose-dependently and significantly inhibited joint pain in both Zy and OA models, while not altering cell influx. Naloxone administration significantly reversed SR analgesia. SR significantly reduced levels of Interleukin-1β and tumor necrosis factor-α in Zy arthritis, whereas those of cytokine-induced neutrophil chemoattractant (CINC)-1 were not altered. Conclusions SR provides analgesia in arthritis that is associated to inhibition of the release of inflammatory cytokines into inflamed joints. This effect is abrogated by administration of the opioid antagonist naloxone.
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spelling Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanismsArtriteCitocinasZimosanObjective We investigated the anti-inflammatory activity of strontium ranelate (SR) in arthritis models. Materials and methods Rats received 1 mg zymosan (Zy) or saline intra-articularly. Other groups were subjected to anterior cruciate ligament transection in the right knee, as an osteoarthritis (OA) model, or a sham procedure. Joint pain was assessed using the articular incapacitation and paw-pressure tests. Cell influx and cytokines were measured in joint exudates. Treatment Groups received either SR (30–300 mg/kg per os) or saline. Results SR dose-dependently and significantly inhibited joint pain in both Zy and OA models, while not altering cell influx. Naloxone administration significantly reversed SR analgesia. SR significantly reduced levels of Interleukin-1β and tumor necrosis factor-α in Zy arthritis, whereas those of cytokine-induced neutrophil chemoattractant (CINC)-1 were not altered. Conclusions SR provides analgesia in arthritis that is associated to inhibition of the release of inflammatory cytokines into inflamed joints. This effect is abrogated by administration of the opioid antagonist naloxone.Inflammation Research2016-06-13T16:50:06Z2016-06-13T16:50:06Z2015-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfNUNES, R. M. et al. Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms. Inflammation Research, Basel, v. 64, n. 10, p. 781-787, oct. 2015.1023-3830http://www.repositorio.ufc.br/handle/riufc/17631Nunes, Rodolfo de MeloMartins, Morgana RamosSilva Junior, Francisco Saraiva daLeite, Ana Caroline Rocha de MeloGirão, Virgínia Cláudia CarneiroCunha, Fernando de QueirozMarinho, Aryana Lushese Lima FeitosaPinto, Ana Carolina Matias DinellyRocha, Francisco Airton Castroengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-03-11T13:13:55Zoai:repositorio.ufc.br:riufc/17631Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2022-03-11T13:13:55Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms
title Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms
spellingShingle Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms
Nunes, Rodolfo de Melo
Artrite
Citocinas
Zimosan
title_short Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms
title_full Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms
title_fullStr Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms
title_full_unstemmed Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms
title_sort Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms
author Nunes, Rodolfo de Melo
author_facet Nunes, Rodolfo de Melo
Martins, Morgana Ramos
Silva Junior, Francisco Saraiva da
Leite, Ana Caroline Rocha de Melo
Girão, Virgínia Cláudia Carneiro
Cunha, Fernando de Queiroz
Marinho, Aryana Lushese Lima Feitosa
Pinto, Ana Carolina Matias Dinelly
Rocha, Francisco Airton Castro
author_role author
author2 Martins, Morgana Ramos
Silva Junior, Francisco Saraiva da
Leite, Ana Caroline Rocha de Melo
Girão, Virgínia Cláudia Carneiro
Cunha, Fernando de Queiroz
Marinho, Aryana Lushese Lima Feitosa
Pinto, Ana Carolina Matias Dinelly
Rocha, Francisco Airton Castro
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nunes, Rodolfo de Melo
Martins, Morgana Ramos
Silva Junior, Francisco Saraiva da
Leite, Ana Caroline Rocha de Melo
Girão, Virgínia Cláudia Carneiro
Cunha, Fernando de Queiroz
Marinho, Aryana Lushese Lima Feitosa
Pinto, Ana Carolina Matias Dinelly
Rocha, Francisco Airton Castro
dc.subject.por.fl_str_mv Artrite
Citocinas
Zimosan
topic Artrite
Citocinas
Zimosan
description Objective We investigated the anti-inflammatory activity of strontium ranelate (SR) in arthritis models. Materials and methods Rats received 1 mg zymosan (Zy) or saline intra-articularly. Other groups were subjected to anterior cruciate ligament transection in the right knee, as an osteoarthritis (OA) model, or a sham procedure. Joint pain was assessed using the articular incapacitation and paw-pressure tests. Cell influx and cytokines were measured in joint exudates. Treatment Groups received either SR (30–300 mg/kg per os) or saline. Results SR dose-dependently and significantly inhibited joint pain in both Zy and OA models, while not altering cell influx. Naloxone administration significantly reversed SR analgesia. SR significantly reduced levels of Interleukin-1β and tumor necrosis factor-α in Zy arthritis, whereas those of cytokine-induced neutrophil chemoattractant (CINC)-1 were not altered. Conclusions SR provides analgesia in arthritis that is associated to inhibition of the release of inflammatory cytokines into inflamed joints. This effect is abrogated by administration of the opioid antagonist naloxone.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
2016-06-13T16:50:06Z
2016-06-13T16:50:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv NUNES, R. M. et al. Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms. Inflammation Research, Basel, v. 64, n. 10, p. 781-787, oct. 2015.
1023-3830
http://www.repositorio.ufc.br/handle/riufc/17631
identifier_str_mv NUNES, R. M. et al. Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms. Inflammation Research, Basel, v. 64, n. 10, p. 781-787, oct. 2015.
1023-3830
url http://www.repositorio.ufc.br/handle/riufc/17631
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Inflammation Research
publisher.none.fl_str_mv Inflammation Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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