Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae)

Detalhes bibliográficos
Autor(a) principal: Menezes, Igor Alexandre Côrtes
Data de Publicação: 2007
Outros Autores: Carvalho, Adriana Andrade, Antoniolli, Angelo Roberto, Santos, Márcio Roberto Viana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/5570
Resumo: Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (AECS) were studied in rats and mice. In non anaesthetized normotensive rats (n = 6), AECS (0.5, 1.0, 5.0 and 10.0 mg/kg; i.v., randomly) induced hypotension associated with tachycardia. In intact or endothelium-denuded rings of rat superior mesenteric artery, AECS (0.1 - 100.0 μ g/ mL, n = 4) provoked relaxation of the tonus induced by 10 μ M phenylephrine. The extract showed low acute toxicity in mic
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spelling Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae)Toxicidade AgudaZingiberaceaeCardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (AECS) were studied in rats and mice. In non anaesthetized normotensive rats (n = 6), AECS (0.5, 1.0, 5.0 and 10.0 mg/kg; i.v., randomly) induced hypotension associated with tachycardia. In intact or endothelium-denuded rings of rat superior mesenteric artery, AECS (0.1 - 100.0 μ g/ mL, n = 4) provoked relaxation of the tonus induced by 10 μ M phenylephrine. The extract showed low acute toxicity in micOs efeitos cardiovasculares e a toxicidade aguda do extrato aquoso das folhas de Costus spicatus (AECS) foram estudados em ratos e camundongos. Em ratos normotensos não-anestesiados, (n = 6), AECS (0.5,1.0, 5 e 10.0 mg/kg; i.v., aleatoriamente) induziu hipotensão associado com taquicardia. Em anéis intactos ou sem endotélio da artéria mesentérica superior de rato, AECS (0.1 - 100.0 μ g/mL, n = 4) provocou relaxamento do tônus induzido por 10 μ M de fenilefrina. O extrato demonstrou baixa toxicidade aguda em camundongosBiologia Geral e Experimental2013-08-06T13:46:44Z2013-08-06T13:46:44Z2007info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMENEZES, I. A. C. ; CARVALHO, A. A. ; ANTONIOLLI, A. R. ; SANTOS, M. R. V. Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae). Biol. Geral Exper., São Cristóvão, SE, v. 7, n. 1, p.9-13, 2007.1519-1982 Impressa1980-9689 On linehttp://www.repositorio.ufc.br/handle/riufc/5570Menezes, Igor Alexandre CôrtesCarvalho, Adriana AndradeAntoniolli, Angelo RobertoSantos, Márcio Roberto Vianaengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-15T17:57:57Zoai:repositorio.ufc.br:riufc/5570Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T19:00:59.277016Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae)
title Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae)
spellingShingle Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae)
Menezes, Igor Alexandre Côrtes
Toxicidade Aguda
Zingiberaceae
title_short Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae)
title_full Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae)
title_fullStr Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae)
title_full_unstemmed Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae)
title_sort Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae)
author Menezes, Igor Alexandre Côrtes
author_facet Menezes, Igor Alexandre Côrtes
Carvalho, Adriana Andrade
Antoniolli, Angelo Roberto
Santos, Márcio Roberto Viana
author_role author
author2 Carvalho, Adriana Andrade
Antoniolli, Angelo Roberto
Santos, Márcio Roberto Viana
author2_role author
author
author
dc.contributor.author.fl_str_mv Menezes, Igor Alexandre Côrtes
Carvalho, Adriana Andrade
Antoniolli, Angelo Roberto
Santos, Márcio Roberto Viana
dc.subject.por.fl_str_mv Toxicidade Aguda
Zingiberaceae
topic Toxicidade Aguda
Zingiberaceae
description Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (AECS) were studied in rats and mice. In non anaesthetized normotensive rats (n = 6), AECS (0.5, 1.0, 5.0 and 10.0 mg/kg; i.v., randomly) induced hypotension associated with tachycardia. In intact or endothelium-denuded rings of rat superior mesenteric artery, AECS (0.1 - 100.0 μ g/ mL, n = 4) provoked relaxation of the tonus induced by 10 μ M phenylephrine. The extract showed low acute toxicity in mic
publishDate 2007
dc.date.none.fl_str_mv 2007
2013-08-06T13:46:44Z
2013-08-06T13:46:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv MENEZES, I. A. C. ; CARVALHO, A. A. ; ANTONIOLLI, A. R. ; SANTOS, M. R. V. Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae). Biol. Geral Exper., São Cristóvão, SE, v. 7, n. 1, p.9-13, 2007.
1519-1982 Impressa
1980-9689 On line
http://www.repositorio.ufc.br/handle/riufc/5570
identifier_str_mv MENEZES, I. A. C. ; CARVALHO, A. A. ; ANTONIOLLI, A. R. ; SANTOS, M. R. V. Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae). Biol. Geral Exper., São Cristóvão, SE, v. 7, n. 1, p.9-13, 2007.
1519-1982 Impressa
1980-9689 On line
url http://www.repositorio.ufc.br/handle/riufc/5570
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Biologia Geral e Experimental
publisher.none.fl_str_mv Biologia Geral e Experimental
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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