Aortocaval fistula delays gastric emptying of liquid test meal in awake rat

Detalhes bibliográficos
Autor(a) principal: Silva, Moisés T. B.
Data de Publicação: 2013
Outros Autores: Palheta Júnior, Raimundo Campos, Oliveira, Francisca G. V., Lima, Juliana B. M. de, Antunes-Rodrigues, José, Oliveira, Ricardo B., Magalhães, Pedro J. C., Santos, Armênio A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/5689
Resumo: Arteriovenous (AV) anastomoses disrupt cardiovascular and renal homeostasis, 25 eliciting hemodynamic adjustments, resetting the humoral pattern, and inducing cardiac 26 hypertrophy. Because acute circulatory imbalance alters gut motor behavior, we studied the 27 effects of AV fistula placement on the gastric emptying (GE) of a liquid meal in awake rats. After 28 laparotomy, we created an aortocaval fistula (ACF) by aorta and cava wall puncture with a 21-, 29 23-, or 26-gauge needle. The ACF was not created in the control group, which underwent sham 30 surgery. After 12, 24, or 48 h, mean arterial pressure (MAP), heart rate (HR), and central venous 31 pressure (CVP) were continuously recorded, and cardiac output (CO) was estimated by thermal 32 dilution. The rats were then gavage-fed a test meal (i.e., phenol red in glucose solution), and 33 fractional dye retention was determined 10, 20, or 30 min later. The effect of prior bleeding on 34 ACF-induced GE delay, the role of neuroautonomic pathways, and changes in plasma hormone 35 levels (i.e., angiotensin II, arginine vasopressin, atrial natriuretic peptide, corticosterone, and 36 oxytocin) were evaluated. Compared with the sham group, ACF rats exhibited arterial 37 hypotension, higher (p < 0.05) HR, CVP, and CO values, and increased (p < 0.05) gastric dye 38 retention, a phenomenon prevented by bilateral subdiaphragmatic vagotomy and 39 hexamethonium treatment. Pirenzepine also impaired the occurrence of gastric delay in virtue 40 of ACF. In addition to causing hyperkinetic circulation, ACF placement delayed the GE of liquid 41 in awake rats, an effect that likely involves a parasympathetic pathway.
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spelling Aortocaval fistula delays gastric emptying of liquid test meal in awake ratFístula ArteriovenosaMotilidade GastrointestinalArteriovenous (AV) anastomoses disrupt cardiovascular and renal homeostasis, 25 eliciting hemodynamic adjustments, resetting the humoral pattern, and inducing cardiac 26 hypertrophy. Because acute circulatory imbalance alters gut motor behavior, we studied the 27 effects of AV fistula placement on the gastric emptying (GE) of a liquid meal in awake rats. After 28 laparotomy, we created an aortocaval fistula (ACF) by aorta and cava wall puncture with a 21-, 29 23-, or 26-gauge needle. The ACF was not created in the control group, which underwent sham 30 surgery. After 12, 24, or 48 h, mean arterial pressure (MAP), heart rate (HR), and central venous 31 pressure (CVP) were continuously recorded, and cardiac output (CO) was estimated by thermal 32 dilution. The rats were then gavage-fed a test meal (i.e., phenol red in glucose solution), and 33 fractional dye retention was determined 10, 20, or 30 min later. The effect of prior bleeding on 34 ACF-induced GE delay, the role of neuroautonomic pathways, and changes in plasma hormone 35 levels (i.e., angiotensin II, arginine vasopressin, atrial natriuretic peptide, corticosterone, and 36 oxytocin) were evaluated. Compared with the sham group, ACF rats exhibited arterial 37 hypotension, higher (p < 0.05) HR, CVP, and CO values, and increased (p < 0.05) gastric dye 38 retention, a phenomenon prevented by bilateral subdiaphragmatic vagotomy and 39 hexamethonium treatment. Pirenzepine also impaired the occurrence of gastric delay in virtue 40 of ACF. In addition to causing hyperkinetic circulation, ACF placement delayed the GE of liquid 41 in awake rats, an effect that likely involves a parasympathetic pathway.American Journal of Physiology. Heart and Circulatory Physiology2013-08-26T16:43:05Z2013-08-26T16:43:05Z2013-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSILVA, M. T. B. et al. Aortocaval fistula delays gastric emptying of liquid test meal in awake rats. American journal of physiology . Heart and circulatory physiology, Bethesda, Md., v.304, p.H1397-1405, mar. 2013.0363-6135http://www.repositorio.ufc.br/handle/riufc/5689Silva, Moisés T. B.Palheta Júnior, Raimundo CamposOliveira, Francisca G. V.Lima, Juliana B. M. deAntunes-Rodrigues, JoséOliveira, Ricardo B.Magalhães, Pedro J. C.Santos, Armênio A.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-05-04T18:16:14Zoai:repositorio.ufc.br:riufc/5689Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:33:01.953922Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Aortocaval fistula delays gastric emptying of liquid test meal in awake rat
title Aortocaval fistula delays gastric emptying of liquid test meal in awake rat
spellingShingle Aortocaval fistula delays gastric emptying of liquid test meal in awake rat
Silva, Moisés T. B.
Fístula Arteriovenosa
Motilidade Gastrointestinal
title_short Aortocaval fistula delays gastric emptying of liquid test meal in awake rat
title_full Aortocaval fistula delays gastric emptying of liquid test meal in awake rat
title_fullStr Aortocaval fistula delays gastric emptying of liquid test meal in awake rat
title_full_unstemmed Aortocaval fistula delays gastric emptying of liquid test meal in awake rat
title_sort Aortocaval fistula delays gastric emptying of liquid test meal in awake rat
author Silva, Moisés T. B.
author_facet Silva, Moisés T. B.
Palheta Júnior, Raimundo Campos
Oliveira, Francisca G. V.
Lima, Juliana B. M. de
Antunes-Rodrigues, José
Oliveira, Ricardo B.
Magalhães, Pedro J. C.
Santos, Armênio A.
author_role author
author2 Palheta Júnior, Raimundo Campos
Oliveira, Francisca G. V.
Lima, Juliana B. M. de
Antunes-Rodrigues, José
Oliveira, Ricardo B.
Magalhães, Pedro J. C.
Santos, Armênio A.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Moisés T. B.
Palheta Júnior, Raimundo Campos
Oliveira, Francisca G. V.
Lima, Juliana B. M. de
Antunes-Rodrigues, José
Oliveira, Ricardo B.
Magalhães, Pedro J. C.
Santos, Armênio A.
dc.subject.por.fl_str_mv Fístula Arteriovenosa
Motilidade Gastrointestinal
topic Fístula Arteriovenosa
Motilidade Gastrointestinal
description Arteriovenous (AV) anastomoses disrupt cardiovascular and renal homeostasis, 25 eliciting hemodynamic adjustments, resetting the humoral pattern, and inducing cardiac 26 hypertrophy. Because acute circulatory imbalance alters gut motor behavior, we studied the 27 effects of AV fistula placement on the gastric emptying (GE) of a liquid meal in awake rats. After 28 laparotomy, we created an aortocaval fistula (ACF) by aorta and cava wall puncture with a 21-, 29 23-, or 26-gauge needle. The ACF was not created in the control group, which underwent sham 30 surgery. After 12, 24, or 48 h, mean arterial pressure (MAP), heart rate (HR), and central venous 31 pressure (CVP) were continuously recorded, and cardiac output (CO) was estimated by thermal 32 dilution. The rats were then gavage-fed a test meal (i.e., phenol red in glucose solution), and 33 fractional dye retention was determined 10, 20, or 30 min later. The effect of prior bleeding on 34 ACF-induced GE delay, the role of neuroautonomic pathways, and changes in plasma hormone 35 levels (i.e., angiotensin II, arginine vasopressin, atrial natriuretic peptide, corticosterone, and 36 oxytocin) were evaluated. Compared with the sham group, ACF rats exhibited arterial 37 hypotension, higher (p < 0.05) HR, CVP, and CO values, and increased (p < 0.05) gastric dye 38 retention, a phenomenon prevented by bilateral subdiaphragmatic vagotomy and 39 hexamethonium treatment. Pirenzepine also impaired the occurrence of gastric delay in virtue 40 of ACF. In addition to causing hyperkinetic circulation, ACF placement delayed the GE of liquid 41 in awake rats, an effect that likely involves a parasympathetic pathway.
publishDate 2013
dc.date.none.fl_str_mv 2013-08-26T16:43:05Z
2013-08-26T16:43:05Z
2013-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SILVA, M. T. B. et al. Aortocaval fistula delays gastric emptying of liquid test meal in awake rats. American journal of physiology . Heart and circulatory physiology, Bethesda, Md., v.304, p.H1397-1405, mar. 2013.
0363-6135
http://www.repositorio.ufc.br/handle/riufc/5689
identifier_str_mv SILVA, M. T. B. et al. Aortocaval fistula delays gastric emptying of liquid test meal in awake rats. American journal of physiology . Heart and circulatory physiology, Bethesda, Md., v.304, p.H1397-1405, mar. 2013.
0363-6135
url http://www.repositorio.ufc.br/handle/riufc/5689
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Journal of Physiology. Heart and Circulatory Physiology
publisher.none.fl_str_mv American Journal of Physiology. Heart and Circulatory Physiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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